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Xufang Deng
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Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages
X Deng, M Hackbart, RC Mettelman, A O’Brien, AM Mielech, G Yi, CC Kao, ...
Proceedings of the National Academy of Sciences 114 (21), E4251-E4260, 2017
3762017
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors
M Hackbart, X Deng, SC Baker
Proceedings of the National Academy of Sciences 117 (14), 8094-8103, 2020
2722020
Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors
A Kilianski, AM Mielech, X Deng, SC Baker
Journal of virology 87 (21), 11955-11962, 2013
1502013
An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses
X Deng, SC Baker
Virology 517, 157-163, 2018
1472018
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus
YM Báez-Santos, AM Mielech, X Deng, S Baker, AD Mesecar
Journal of virology 88 (21), 12511-12527, 2014
1462014
Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir
Y Hu, EM Lewandowski, H Tan, X Zhang, RT Morgan, X Zhang, ...
ACS central science 9 (8), 1658-1669, 2023
1262023
Coronavirus endoribonuclease activity in porcine epidemic diarrhea virus suppresses type I and type III interferon responses
X Deng, A van Geelen, AC Buckley, A O’Brien, A Pillatzki, KM Lager, ...
Journal of virology 93 (8), 10.1128/jvi. 02000-18, 2019
1152019
Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity
Z Zhu, Z Shi, W Yan, J Wei, D Shao, X Deng, S Wang, B Li, G Tong, Z Ma
PloS one 8 (2), e55920, 2013
1102013
Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance
X Deng, SE StJohn, HL Osswald, A O'Brien, BS Banach, K Sleeman, ...
Journal of Virology 88 (20), 11886-11898, 2014
1042014
Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model
Z Shi, J Wei, X Deng, S Li, Y Qiu, D Shao, B Li, K Zhang, F Xue, X Wang, ...
Virology journal 11, 1-10, 2014
772014
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis
AM Mielech, X Deng, Y Chen, E Kindler, DL Wheeler, AD Mesecar, ...
Journal of virology 89 (9), 4907-4917, 2015
712015
The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities
X Deng, X Li, Y Shen, Y Qiu, Z Shi, D Shao, Y Jin, H Chen, C Ding, L Li, ...
Virology journal 7, 1-11, 2010
622010
Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53
X Wang, X Deng, W Yan, Z Zhu, Y Shen, Y Qiu, Z Shi, D Shao, J Wei, ...
Journal of Biological Chemistry 287 (22), 18366-18375, 2012
502012
Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection
W Yan, J Wei, X Deng, Z Shi, Z Zhu, D Shao, B Li, S Wang, G Tong, Z Ma
BMC medical genomics 8, 1-10, 2015
412015
Coronavirus endoribonuclease and deubiquitinating interferon antagonists differentially modulate the host response during replication in macrophages
A Volk, M Hackbart, X Deng, Y Cruz-Pulido, A O’Brien, SC Baker
Journal of virology 94 (11), 10.1128/jvi. 00178-20, 2020
402020
Analysis of coronavirus temperature-sensitive mutants reveals an interplay between the macrodomain and papain-like protease impacting replication and pathogenesis
X Deng, RC Mettelman, A O’Brien, JA Thompson, TE O’Brien, SC Baker
Journal of Virology 93 (12), 10.1128/jvi. 02140-18, 2019
332019
Structure-guided mutagenesis alters deubiquitinating activity and attenuates pathogenesis of a murine coronavirus
X Deng, Y Chen, AM Mielech, M Hackbart, KR Kesely, RC Mettelman, ...
Journal of virology 94 (11), 10.1128/jvi. 01734-19, 2020
302020
Inactivating three interferon antagonists attenuates pathogenesis of an enteric coronavirus
X Deng, AC Buckley, A Pillatzki, KM Lager, KS Faaberg, SC Baker
Journal of virology 94 (17), 10.1128/jvi. 00565-20, 2020
242020
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses
X Deng, S Agnihothram, AM Mielech, DB Nichols, MW Wilson, SE StJohn, ...
Journal of virology 88 (20), 11825-11833, 2014
222014
Characterization of nonstructural protein 3 of a neurovirulent Japanese encephalitis virus strain isolated from a pig
X Deng, Z Shi, S Li, X Wang, Y Qiu, D Shao, J Wei, G Tong, Z Ma
Virology Journal 8, 1-10, 2011
222011
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Articles 1–20