| Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ... Nature 555 (7694), 121-125, 2018 | 298 | 2018 |
| Biased signaling of protease-activated receptors P Zhao, M Metcalf, NW Bunnett Frontiers in endocrinology 5, 91196, 2014 | 286 | 2014 |
| The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice TM Lieu, G Jayaweera, P Zhao, DP Poole, D Jensen, M Grace, P McIntyre, ... Gastroenterology 147 (6), 1417-1428, 2014 | 225 | 2014 |
| Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4 P Zhao, TM Lieu, N Barlow, M Metcalf, NA Veldhuis, DD Jensen, M Kocan, ... Journal of Biological Chemistry 289 (39), 27215-27234, 2014 | 182 | 2014 |
| Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain P Zhao, TM Lieu, N Barlow, S Sostegni, S Haerteis, C Korbmacher, ... Journal of Biological Chemistry 290 (22), 13875-13887, 2015 | 165 | 2015 |
| Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome NN Jimenez-Vargas, LA Pattison, P Zhao, TM Lieu, R Latorre, DD Jensen, ... Proceedings of the National Academy of Sciences 115 (31), E7438-E7447, 2018 | 149 | 2018 |
| Activation of the GLP-1 receptor by a non-peptidic agonist P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ... Nature 577 (7790), 432-436, 2020 | 131 | 2020 |
| Structural basis of Gs and Gi recognition by the human glucagon receptor A Qiao, S Han, X Li, Z Li, P Zhao, A Dai, R Chang, L Tai, Q Tan, X Chu, ... Science 367 (6484), 1346-1352, 2020 | 126 | 2020 |
| Differential GLP-1R binding and activation by peptide and non-peptide agonists X Zhang, MJ Belousoff, P Zhao, AJ Kooistra, TT Truong, SY Ang, ... Molecular Cell 80 (3), 485-500. e7, 2020 | 120 | 2020 |
| Toward a structural understanding of class B GPCR peptide binding and activation YL Liang, MJ Belousoff, P Zhao, C Koole, MM Fletcher, TT Truong, ... Molecular cell 77 (3), 656-668. e5, 2020 | 95 | 2020 |
| Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination YL Liang, P Zhao, C Draper-Joyce, JA Baltos, A Glukhova, TT Truong, ... ACS pharmacology & translational science 1 (1), 12-20, 2018 | 92 | 2018 |
| Translational control by RGS2 CH Nguyen, H Ming, P Zhao, L Hugendubler, R Gros, SR Kimball, ... Journal of cell biology 186 (5), 755-765, 2009 | 72 | 2009 |
| Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists MM Fletcher, ML Halls, P Zhao, L Clydesdale, A Christopoulos, ... Biochemical Pharmacology 156, 406-419, 2018 | 49 | 2018 |
| Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism S Lei, L Clydesdale, A Dai, X Cai, Y Feng, D Yang, YL Liang, C Koole, ... Journal of Biological Chemistry 293 (24), 9370-9387, 2018 | 49 | 2018 |
| Pharmacological characterization of mono-, dual-and tri-peptidic agonists at GIP and GLP-1 receptors E Yuliantie, S Darbalaei, A Dai, P Zhao, D Yang, PM Sexton, MW Wang, ... Biochemical Pharmacology 177, 114001, 2020 | 42 | 2020 |
| Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation G Deganutti, YL Liang, X Zhang, M Khoshouei, L Clydesdale, ... Nature Communications 13 (1), 92, 2022 | 39 | 2022 |
| Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons P Zhao, M Canals, JE Murphy, D Klingler, EM Eriksson, JC Pelayo, ... Journal of Biological Chemistry 288 (36), 25689-25700, 2013 | 38 | 2013 |
| Granzyme A in chikungunya and other arboviral infections AS Schanoski, TT Le, D Kaiserman, C Rowe, NA Prow, DD Barboza, ... Frontiers in immunology 10, 3083, 2020 | 37 | 2020 |
| Resistance to age-related, normal body weight gain in RGS2 deficient mice C Nunn, P Zhao, MX Zou, K Summers, CG Guglielmo, P Chidiac Cellular signalling 23 (8), 1375-1386, 2011 | 37 | 2011 |
| AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists MM Fletcher, P Keov, TT Truong, G Mennen, CA Hick, P Zhao, ... Journal of Pharmacology and Experimental Therapeutics 377 (3), 417-440, 2021 | 33 | 2021 |
