| Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of [alpha]-Ketoglutarate-Dependent Dioxygenases W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ... Cancer Cell 19 (1), 17-30, 2011 | 3006 | 2011 |
| In silico design of novel probes for the atypical opioid receptor MRGPRX2 K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ... Nature chemical biology 13 (5), 529-536, 2017 | 255 | 2017 |
| A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases MS Eram, Y Shen, MM Szewczyk, H Wu, G Senisterra, F Li, KV Butler, ... ACS chemical biology 11 (3), 772-781, 2016 | 232 | 2016 |
| Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys Y Nagai, N Miyakawa, H Takuwa, Y Hori, K Oyama, B Ji, M Takahashi, ... Nature neuroscience 23 (9), 1157-1167, 2020 | 218 | 2020 |
| Proteolysis targeting chimeras (PROTACs) of anaplastic lymphoma kinase (ALK) C Zhang, XR Han, X Yang, B Jiang, J Liu, Y Xiong, J Jin European journal of medicinal chemistry 151, 304-314, 2018 | 194 | 2018 |
| DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo KJ Thompson, E Khajehali, SJ Bradley, JS Navarrete, XP Huang, ... ACS Pharmacology & Translational Science 1 (1), 61-72, 2018 | 163 | 2018 |
| Cell cycle on the crossroad of tumorigenesis and cancer therapy J Liu, Y Peng, W Wei Trends in cell biology 32 (1), 30-44, 2022 | 158 | 2022 |
| MERTK receptor tyrosine kinase is a therapeutic target in melanoma J Schlegel, MJ Sambade, S Sather, SJ Moschos, AC Tan, A Winges, ... The Journal of clinical investigation 123 (5), 2257-2267, 2013 | 150 | 2013 |
| UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor W Zhang, D DeRyckere, D Hunter, J Liu, MA Stashko, KA Minson, ... Journal of medicinal chemistry 57 (16), 7031-7041, 2014 | 145 | 2014 |
| Structural determinants of 5-HT2B receptor activation and biased agonism JD McCorvy, D Wacker, S Wang, B Agegnehu, J Liu, K Lansu, AR Tribo, ... Nature structural & molecular biology 25 (9), 787-796, 2018 | 134 | 2018 |
| Synthesis of resveratrol using a direct decarbonylative Heck approach from resorcylic acid MB Andrus, J Liu, EL Meredith, E Nartey Tetrahedron letters 44 (26), 4819-4822, 2003 | 134 | 2003 |
| Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders M Cheng, X Yu, K Lu, L Xie, L Wang, F Meng, X Han, X Chen, J Liu, ... Journal of medicinal chemistry 63 (3), 1216-1232, 2020 | 122 | 2020 |
| A chemical biology toolbox to study protein methyltransferases and epigenetic signaling S Scheer, S Ackloo, TS Medina, M Schapira, F Li, JA Ward, AM Lewis, ... Nature communications 10 (1), 19, 2019 | 108 | 2019 |
| Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia J Liu, C Yang, C Simpson, D DeRyckere, A Van Deusen, MJ Miley, ... ACS Medicinal Chemistry Letters 3 (2), 129-134, 2012 | 101 | 2012 |
| EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis J Wang, X Yu, W Gong, X Liu, KS Park, A Ma, YH Tsai, Y Shen, T Onikubo, ... Nature cell biology 24 (3), 384-399, 2022 | 92 | 2022 |
| UNC1062, a new and potent Mer inhibitor J Liu, W Zhang, MA Stashko, et al. European Journal of Medicinal Chemistry, 2013 | 83 | 2013 |
| Discovery of a potent, selective, and cell-active dual inhibitor of protein arginine methyltransferase 4 and protein arginine methyltransferase 6 Y Shen, MM Szewczyk, MS Eram, D Smil, HU Kaniskan, ... Journal of medicinal chemistry 59 (19), 9124-9139, 2016 | 77 | 2016 |
| UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo S Christoph, D DeRyckere, J Schlegel, JK Frazer, LA Batchelor, ... Molecular cancer therapeutics 12 (11), 2367-2377, 2013 | 76 | 2013 |
| Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors F Liu, F Li, A Ma, E Dobrovetsky, A Dong, C Gao, I Korboukh, J Liu, D Smil, ... Journal of medicinal chemistry 56 (5), 2110-2124, 2013 | 76 | 2013 |
| A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models X Yu, D Li, J Kottur, Y Shen, HS Kim, KS Park, YH Tsai, W Gong, J Wang, ... Science translational medicine 13 (613), eabj1578, 2021 | 71 | 2021 |
