Kerensa Broersen
Kerensa Broersen
Universiteit Twente, MIRA Instituut
Verified email at utwente.nl
TitleCited byYear
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
I Kuperstein, K Broersen, I Benilova, J Rozenski, W Jonckheere, ...
The EMBO journal 29 (19), 3408-3420, 2010
4162010
The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ...
The EMBO journal 31 (10), 2261-2274, 2012
3692012
Structural basis for increased toxicity of pathological aβ42: aβ40 ratios in Alzheimer disease
K Pauwels, TL Williams, KL Morris, W Jonckheere, A Vandersteen, ...
Journal of biological chemistry 287 (8), 5650-5660, 2012
1792012
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
K Broersen, F Rousseau, J Schymkowitz
Alzheimer's research & therapy 2 (4), 12, 2010
1302010
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease
K Broersen, W Jonckheere, J Rozenski, A Vandersteen, K Pauwels, ...
Protein Engineering, Design & Selection 24 (9), 743-750, 2011
912011
Mechanism of arachidonic acid action on syntaxin–Munc18
E Connell, F Darios, K Broersen, N Gatsby, SY Peak‐Chew, C Rickman, ...
EMBO reports 8 (4), 414-419, 2007
892007
Glycoforms of β‐lactoglobulin with improved thermostability and preserved structural packing
K Broersen, AGJ Voragen, RJ Hamer, HHJ de Jongh
Biotechnology and Bioengineering 86 (1), 78-87, 2004
882004
Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation
L Zhou, N Brouwers, I Benilova, A Vandersteen, M Mercken, K Van Laere, ...
EMBO molecular medicine 3 (5), 291-302, 2011
842011
Transient dynamics of Aβ contribute to toxicity in Alzheimer’s disease
E Hubin, NAJ Van Nuland, K Broersen, K Pauwels
Cellular and molecular life sciences 71 (18), 3507-3521, 2014
692014
α-Synuclein adopts an α-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation
K Broersen, D van den Brink, G Fraser, M Goedert, B Davletov
Biochemistry 45 (51), 15610-15616, 2006
602006
Do sulfhydryl groups affect aggregation and gelation properties of ovalbumin?
K Broersen, AMM Van Teeffelen, A Vries, AGJ Voragen, RJ Hamer, ...
Journal of agricultural and food chemistry 54 (14), 5166-5174, 2006
582006
A comparative analysis of the aggregation behavior of amyloid‐β peptide variants
A Vandersteen, E Hubin, R Sarroukh, G De Baets, J Schymkowitz, ...
FEBS letters 586 (23), 4088-4093, 2012
502012
Glucosylation of β‐lactoglobulin lowers the heat capacity change of unfolding; a unique way to affect protein thermodynamics
AMM Van Teeffelen, K Broersen, HHJ de Jongh
Protein Science 14 (8), 2187-2194, 2005
472005
Chemical processing as a tool to generate ovalbumin variants with changed stability
HA Kosters, K Broersen, J de Groot, JWFA Simons, P Wierenga, ...
Biotechnology and Bioengineering 84 (1), 61-70, 2003
422003
Mechanistic insights in glycation-induced protein aggregation
M Adrover, L Mariño, P Sanchis, K Pauwels, Y Kraan, P Lebrun, ...
Biomacromolecules 15 (9), 3449-3462, 2014
342014
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool
A Vandersteen, MF Masman, G De Baets, W Jonckheere, K Van der Werf, ...
Journal of biological chemistry 287 (44), 36732-36743, 2012
342012
Net charge affects morphology and visual properties of ovalbumin aggregates
M Weijers, K Broersen, PA Barneveld, MA Cohen Stuart, RJ Hamer, ...
Biomacromolecules 9 (11), 3165-3172, 2008
332008
Effect of protein charge on the generation of aggregation-prone conformers
K Broersen, M Weijers, J de Groot, RJ Hamer, HHJ de Jongh
Biomacromolecules 8 (5), 1648-1656, 2007
282007
α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants
A Siekierska, G De Baets, J Reumers, R Gallardo, S Rudyak, K Broersen, ...
Journal of Biological Chemistry 287 (34), 28386-28397, 2012
262012
α-Galactosidase aggregation is a determinant of pharmacological chaperone efficacy on Fabry disease mutants
A Siekierska, G De Baets, J Reumers, R Gallardo, S Rudyak, K Broersen, ...
Journal of Biological Chemistry 287 (34), 28386-28397, 2012
262012
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