Rana Rais
Rana Rais
Associate Professor, Johns Hopkins
Verified email at - Homepage
Cited by
Cited by
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
RD Leone, L Zhao, JM Englert, IM Sun, MH Oh, IH Sun, ML Arwood, ...
Science 366 (6468), 1013-1021, 2019
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
MH Oh, IH Sun, L Zhao, RD Leone, IM Sun, W Xu, SL Collins, AJ Tam, ...
The Journal of clinical investigation 130 (7), 3865-3884, 2020
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1, 2, 4-thiadiazol-2-yl) ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors
K Shukla, DV Ferraris, AG Thomas, M Stathis, B Duvall, G Delahanty, J Alt, ...
Journal of medicinal chemistry 55 (23), 10551-10563, 2012
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer
A Elgogary, Q Xu, B Poore, J Alt, SC Zimmermann, L Zhao, J Fu, B Chen, ...
Proceedings of the National Academy of Sciences 113 (36), E5328-E5336, 2016
We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine
KM Lemberg, JJ Vornov, R Rais, BS Slusher
Molecular cancer therapeutics 17 (9), 1824-1832, 2018
Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma
R Rais, A Jancarik, L Tenora, M Nedelcovych, J Alt, J Englert, C Rojas, ...
Journal of medicinal chemistry 59 (18), 8621-8633, 2016
Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV
JM Coughlin, Y Wang, S Ma, C Yue, PK Kim, AV Adams, HV Roosa, ...
Journal of neurovirology 20, 219-232, 2014
Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis
KA Rahn, CC Watkins, J Alt, R Rais, M Stathis, I Grishkan, CM Crainiceau, ...
Proceedings of the National Academy of Sciences 109 (49), 20101-20106, 2012
Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid …
V Kumar, A Bonifazi, MP Ellenberger, TM Keck, E Pommier, R Rais, ...
Journal of medicinal chemistry 59 (16), 7634-7650, 2016
Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo
A Ghosh, L Li, L Xu, RP Dash, N Gupta, J Lam, Q Jin, V Akshintala, ...
Science advances 6 (44), eabb4133, 2020
Dopamine D3R antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects
ZB You, GH Bi, E Galaj, V Kumar, J Cao, A Gadiano, R Rais, BS Slusher, ...
Neuropsychopharmacology 44 (8), 1415-1424, 2019
Clinical development of metabolic inhibitors for oncology
KM Lemberg, SS Gori, T Tsukamoto, R Rais, BS Slusher
The Journal of clinical investigation 132 (1), 2022
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated …
MT Nedelcovych, L Tenora, BH Kim, J Kelschenbach, W Chao, E Hadas, ...
Journal of medicinal chemistry 60 (16), 7186-7198, 2017
The highly selective dopamine D3R antagonist, R-VK4-40 attenuates oxycodone reward and augments analgesia in rodents
CJ Jordan, B Humburg, M Rice, GH Bi, ZB You, AB Shaik, J Cao, ...
Neuropharmacology 158, 107597, 2019
Novel and high affinity 2-[(diphenylmethyl) sulfinyl] acetamide (modafinil) analogues as atypical dopamine transporter inhibitors
J Cao, RD Slack, OM Bakare, C Burzynski, R Rais, BS Slusher, T Kopajtic, ...
Journal of medicinal chemistry 59 (23), 10676-10691, 2016
Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma
AR Hanaford, J Alt, R Rais, SZ Wang, H Kaur, DLJ Thorek, CG Eberhart, ...
Translational oncology 12 (10), 1314-1322, 2019
High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice
CA Boateng, OM Bakare, J Zhan, AK Banala, C Burzynski, E Pommier, ...
Journal of medicinal chemistry 58 (15), 6195-6213, 2015
Still NAAG’ing after all these years: the continuing pursuit of GCPII inhibitors
JJ Vornov, KR Hollinger, PF Jackson, KM Wozniak, MH Farah, P Majer, ...
Advances in Pharmacology 76, 215-255, 2016
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
R Rais, KM Lemberg, L Tenora, ML Arwood, A Pal, J Alt, Y Wu, J Lam, ...
Science advances 8 (46), eabq5925, 2022
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation
C Rojas, E Barnaeva, AG Thomas, X Hu, N Southall, J Marugan, ...
Scientific reports 8 (1), 17715, 2018
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