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Sylvia Fanucchi
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Formation of an unfolding intermediate state of soluble chloride intracellular channel protein CLIC1 at acidic pH
S Fanucchi, RJ Adamson, HW Dirr
Biochemistry 47 (44), 11674-11681, 2008
672008
Structural dynamics of soluble chloride intracellular channel protein CLIC1 examined by amide hydrogen− deuterium exchange mass spectrometry
SH Stoychev, C Nathaniel, S Fanucchi, M Brock, S Li, K Asmus, ...
Biochemistry 48 (35), 8413-8421, 2009
552009
Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance
P Naicker, I Achilonu, S Fanucchi, M Fernandes, MAA Ibrahim, HW Dirr, ...
Journal of Biomolecular Structure and Dynamics 31 (12), 1370-1380, 2013
482013
Role of individual histidines in the pH-dependent global stability of human chloride intracellular channel 1
I Achilonu, S Fanucchi, M Cross, M Fernandes, HW Dirr
Biochemistry 51 (5), 995-1004, 2012
352012
Effect of pH on the Structure and DNA Binding of the FOXP2 Forkhead Domain
A Blane, S Fanucchi
Biochemistry 54 (25), 4001-4007, 2015
252015
A Lys–Trp cation− π interaction mediates the dimerization and function of the chloride intracellular channel protein 1 transmembrane domain
B Peter, AA Polyansky, S Fanucchi, HW Dirr
Biochemistry 53 (1), 57-67, 2014
242014
A single amino acid in the hinge loop region of the FOXP forkhead domain is significant for dimerisation
K Perumal, HW Dirr, S Fanucchi
The Protein Journal 34, 111-121, 2015
232015
Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1
D Balchin, S Fanucchi, I Achilonu, RJ Adamson, J Burke, M Fernandes, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (12), 2228-2233, 2010
232010
A key evolutionary mutation enhances DNA binding of the FOXP2 forkhead domain
G Morris, S Fanucchi
Biochemistry 55 (13), 1959-1967, 2016
182016
Role of arginine 29 and glutamic acid 81 interactions in the conformational stability of human chloride intracellular channel 1
D Legg-E’Silva, I Achilonu, S Fanucchi, S Stoychev, M Fernandes, ...
Biochemistry 51 (40), 7854-7862, 2012
172012
Membrane mimetics induce helix formation and oligomerization of the chloride intracellular channel protein 1 transmembrane domain
B Peter, NCML Ngubane, S Fanucchi, HW Dirr
Biochemistry 52 (16), 2739-2749, 2013
152013
The FOXP2 forkhead domain binds to a variety of DNA sequences with different rates and affinities
H Webb, O Steeb, A Blane, L Rotherham, S Aron, P Machanick, H Dirr, ...
The journal of biochemistry 162 (1), 45-54, 2017
142017
Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: Insights into biophysical and structural studies
BO Akumadu, R Pandian, J Olfsen, R Worth, M Thulo, T Mentor, ...
Molecular and Biochemical Parasitology 240, 111319, 2020
122020
A phosphomimetic study implicates Ser557 in regulation of FOXP2 DNA binding
A Blane, HW Dirr, S Fanucchi
The protein journal 37, 311-323, 2018
102018
The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function
I Achilonu, S Gildenhuys, L Fisher, J Burke, S Fanucchi, BT Sewell, ...
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2010
102010
The forkhead domain hinge-loop plays a pivotal role in DNA binding and transcriptional activity of FOXP2
G Morris, S Stoychev, P Naicker, HW Dirr, S Fanucchi
Biological Chemistry 399 (8), 881-893, 2018
92018
The influence of various regions of the FOXP2 sequence on its structure and DNA-binding function
M Thulo, MA Rabie, N Pahad, HL Donald, AA Blane, CM Perumal, ...
Bioscience Reports 41 (1), BSR20202128, 2021
82021
A conserved cationic motif enhances membrane binding and insertion of the chloride intracellular channel protein 1 transmembrane domain
B Peter, S Fanucchi, HW Dirr
European Biophysics Journal 43, 405-414, 2014
72014
A conserved interdomain interaction is a determinant of folding cooperativity in the GST fold
N Parbhoo, SH Stoychev, S Fanucchi, I Achilonu, RJ Adamson, ...
Biochemistry 50 (32), 7067-7075, 2011
62011
A conserved cation binding site in the DNA binding domain of forkhead box transcription factors regulates DNA binding by FOXP2
G Morris, N Pahad, HW Dirr, S Fanucchi
Archives of biochemistry and biophysics 657, 56-64, 2018
42018
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