tim bartels
tim bartels
University College London, Dementia Research Institute
Verified email at ucl.ac.uk - Homepage
Cited by
Cited by
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
T Bartels, JG Choi, DJ Selkoe
Nature 477 (7362), 107-110, 2011
Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1
F Kamp, N Exner, AK Lutz, N Wender, J Hegermann, B Brunner, ...
The EMBO journal 29 (20), 3571-3589, 2010
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
T Bartels, LS Ahlstrom, A Leftin, F Kamp, C Haass, MF Brown, K Beyer
Biophysical journal 99 (7), 2116-2124, 2010
β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease
S Mittal, K Bjørnevik, DS Im, A Flierl, X Dong, JJ Locascio, KM Abo, ...
Science 357 (6354), 891-898, 2017
Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ...
Nature communications 6 (1), 1-16, 2015
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells
U Dettmer, AJ Newman, ES Luth, T Bartels, D Selkoe
Journal of Biological Chemistry 288 (9), 6371-6385, 2013
Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction
ES Luth, IG Stavrovskaya, T Bartels, BS Kristal, DJ Selkoe
Journal of Biological Chemistry 289 (31), 21490-21507, 2014
Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes
S Hong, BL Ostaszewski, T Yang, TT O’Malley, M Jin, K Yanagisawa, S Li, ...
Neuron 82 (2), 308-319, 2014
N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation
T Bartels, NC Kim, ES Luth, DJ Selkoe
PloS one 9 (7), e103727, 2014
Raftlike Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State 2H NMR Spectroscopy
T Bartels, RS Lankalapalli, R Bittman, K Beyer, MF Brown
Journal of the American Chemical Society 130 (44), 14521-14532, 2008
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
U Dettmer, AJ Newman, VE von Saucken, T Bartels, D Selkoe
Proceedings of the National Academy of Sciences 112 (31), 9596-9601, 2015
New insights into cellular α-synuclein homeostasis in health and disease
U Dettmer, D Selkoe, T Bartels
Current opinion in neurobiology 36, 15-22, 2016
Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity
ES Luth, T Bartels, U Dettmer, NC Kim, DJ Selkoe
Biochemistry 54 (2), 279-292, 2015
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
J Schapansky, S Khasnavis, MP DeAndrade, JD Nardozzi, SR Falkson, ...
Neurobiology of disease 111, 26-35, 2018
Defining the native state of α-synuclein
D Selkoe, U Dettmer, E Luth, N Kim, A Newman, T Bartels
Neurodegenerative Diseases 13 (2-3), 114-117, 2014
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells
U Dettmer, N Ramalingam, VE von Saucken, TE Kim, AJ Newman, ...
Human molecular genetics 26 (18), 3466-3481, 2017
Refolding of helical soluble α‐synuclein through transient interaction with lipid interfaces
M Rovere, JB Sanderson, L Fonseca‐Ornelas, DS Patel, T Bartels
Febs Letters 592 (9), 1464-1472, 2018
Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
U Dettmer, AJ Newman, F Soldner, ES Luth, NC Kim, VE Von Saucken, ...
Nature communications 6, 2015
E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity
M Rovere, AE Powers, H Jiang, JC Pitino, L Fonseca-Ornelas, DS Patel, ...
Journal of Biological Chemistry 294 (25), 9799-9812, 2019
A traffic jam leads to Lewy bodies
T Bartels
Nature Neuroscience 22 (7), 1043-1045, 2019
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