| Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery TL Blundell, BL Sibanda, RW Montalvão, S Brewerton, V Chelliah, ... Philosophical Transactions of the Royal Society B: Biological Sciences 361 …, 2006 | 242 | 2006 |
| Determination of protein-ligand interactions using differential scanning fluorimetry M Vivoli, HR Novak, JA Littlechild, NJ Harmer JoVE (Journal of Visualized Experiments), e51809, 2014 | 178 | 2014 |
| The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity, NJ Harmer, L Pellegrini, D Chirgadze, J Fernandez-Recio, TL Blundell Biochemistry 43 (3), 629-640, 2004 | 177 | 2004 |
| Insights into the role of heparan sulphate in fibroblast growth factor signalling NJ Harmer Biochemical Society Transactions 34 (3), 442-445, 2006 | 152 | 2006 |
| Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)–FGF receptor–heparin complex NJ Harmer, LL Ilag, B Mulloy, L Pellegrini, CV Robinson, TL Blundell Journal of molecular biology 339 (4), 821-834, 2004 | 145 | 2004 |
| A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens AC Schuh, NA Watkins, Q Nguyen, NJ Harmer, M Lin, JYA Prosper, ... Blood, The Journal of the American Society of Hematology 99 (5), 1692-1698, 2002 | 131 | 2002 |
| Characterization of carboxylic acid reductases as enzymes in the toolbox for synthetic chemistry W Finnigan, A Thomas, H Cromar, B Gough, R Snajdrova, JP Adams, ... ChemCatChem 9 (6), 1005-1017, 2017 | 130 | 2017 |
| Zoonoses under our noses AR Cross, VM Baldwin, S Roy, AE Essex-Lopresti, JL Prior, NJ Harmer Microbes and infection 21 (1), 10-19, 2019 | 116 | 2019 |
| Myosin‐5, kinesin‐1 and myosin‐17 cooperate in secretion of fungal chitin synthase M Schuster, S Treitschke, S Kilaru, J Molloy, NJ Harmer, G Steinberg The EMBO journal 31 (1), 214-227, 2012 | 112 | 2012 |
| The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation A Butt, VA Higman, C Williams, MP Crump, CM Hemsley, N Harmer, ... Biochemical Journal 459 (2), 333-344, 2014 | 104 | 2014 |
| Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms SJ Goodger, CJ Robinson, KJ Murphy, N Gasiunas, NJ Harmer, ... Journal of Biological Chemistry 283 (19), 13001-13008, 2008 | 99 | 2008 |
| Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2: 2: 1 FGF1· FGFR2c· heparin ternary complexes CJ Robinson, NJ Harmer, SJ Goodger, TL Blundell, JT Gallagher Journal of biological chemistry 280 (51), 42274-42282, 2005 | 97 | 2005 |
| Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region J Cuccui, TS Milne, N Harmer, AJ George, SV Harding, RE Dean, ... Infection and immunity 80 (3), 1209-1221, 2012 | 71 | 2012 |
| Multimers of the fibroblast growth factor (FGF)–FGF receptor–saccharide complex are formed on long oligomers of heparin NJ Harmer, CJ Robinson, LE Adam, LL Ilag, CV Robinson, JT Gallagher, ... Biochemical journal 393 (3), 741-748, 2006 | 62 | 2006 |
| A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence IH Norville, NJ Harmer, SV Harding, G Fischer, KE Keith, KA Brown, ... Infection and immunity 79 (11), 4299-4307, 2011 | 53 | 2011 |
| Engineering a seven enzyme biotransformation using mathematical modelling and characterized enzyme parts W Finnigan, R Cutlan, R Snajdrova, JP Adams, JA Littlechild, NJ Harmer ChemCatChem 11 (15), 3474-3489, 2019 | 49 | 2019 |
| Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases R Cutlan, S De Rose, MN Isupov, JA Littlechild, NJ Harmer Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1868 (2), 140322, 2020 | 47 | 2020 |
| Highly thermostable carboxylic acid reductases generated by ancestral sequence reconstruction A Thomas, R Cutlan, W Finnigan, M van der Giezen, N Harmer Communications Biology 2 (1), 429, 2019 | 47 | 2019 |
| Effect of Substance P in Staphylococcus aureus and Staphylococcus epidermidis Virulence: Implication for Skin Homeostasis A N'Diaye, L Mijouin, M Hillion, S Diaz, Y Konto-Ghiorghi, G Percoco, ... Frontiers in microbiology 7, 506, 2016 | 45 | 2016 |
| Pseudomonas aeruginosa expresses a functional human natriuretic peptide receptor ortholog: involvement in biofilm formation T Rosay, A Bazire, S Diaz, T Clamens, AS Blier, L Mijouin, B Hoffmann, ... MBio 6 (4), 10.1128/mbio. 01033-15, 2015 | 38 | 2015 |
Tom L BlundellEmeritus Professor of Biochemistry, University of CambridgeEmail verificata su cam.ac.uk
