| Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus MA Lee-Kirsch, M Gong, D Chowdhury, L Senenko, K Engel, YA Lee, ... Nature genetics 39 (9), 1065-1067, 2007 | 736 | 2007 |
| Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase*♦ RD Powell, PJ Holland, T Hollis, FW Perrino Journal of Biological Chemistry 286 (51), 43596-43600, 2011 | 409 | 2011 |
| Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome G Rice, WG Newman, J Dean, T Patrick, R Parmar, K Flintoff, P Robins, ... The American Journal of Human Genetics 80 (4), 811-815, 2007 | 405 | 2007 |
| Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3′→ 5′ exonucleases DJ Mazur, FW Perrino Journal of Biological Chemistry 274 (28), 19655-19660, 1999 | 317 | 1999 |
| The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death D Chowdhury, PJ Beresford, P Zhu, D Zhang, JS Sung, B Demple, ... Molecular cell 23 (1), 133-142, 2006 | 310 | 2006 |
| Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort B Namjou, PH Kothari, JA Kelly, SB Glenn, JO Ojwang, A Adler, ... Genes & Immunity 12 (4), 270-279, 2011 | 273 | 2011 |
| A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus MA Lee-Kirsch, D Chowdhury, S Harvey, M Gong, L Senenko, K Engel, ... Journal of Molecular Medicine 85, 531-537, 2007 | 244 | 2007 |
| Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural … W Lewis, ES Levine, B Griniuviene, KO Tankersley, JM Colacino, ... Proceedings of the National Academy of Sciences 93 (8), 3592-3597, 1996 | 215 | 1996 |
| A DNA polymerase-α· primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells DE Casteel, S Zhuang, Y Zeng, FW Perrino, GR Boss, M Goulian, RB Pilz Journal of biological chemistry 284 (9), 5807-5818, 2009 | 202 | 2009 |
| Excision of 3′ Termini by the Trex1 and TREX2 3′→ 5′ Exonucleases: characterization of the recombinant proteins DJ Mazur, FW Perrino Journal of Biological Chemistry 276 (20), 17022-17029, 2001 | 184 | 2001 |
| Extension of mismatched 3'termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase. FW Perrino, BD Preston, LL Sandell, LA Loeb Proceedings of the National Academy of Sciences 86 (21), 8343-8347, 1989 | 170 | 1989 |
| Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease JL Grieves, JM Fye, S Harvey, JM Grayson, T Hollis, FW Perrino Proceedings of the National Academy of Sciences 112 (16), 5117-5122, 2015 | 150 | 2015 |
| The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease DA Lehtinen, S Harvey, MJ Mulcahy, T Hollis, FW Perrino Journal of biological chemistry 283 (46), 31649-31656, 2008 | 149 | 2008 |
| Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α FW Perrino, LA Loeb Journal of Biological Chemistry 264 (5), 2898-2905, 1989 | 147 | 1989 |
| The crystal structure of TREX1 explains the 3′ nucleotide specificity and reveals a polyproline II helix for protein partnering U de Silva, S Choudhury, SL Bailey, S Harvey, FW Perrino, T Hollis Journal of Biological Chemistry 282 (14), 10537-10543, 2007 | 132 | 2007 |
| Structure and expression of the TREX1 and TREX2 3′→ 5′ exonuclease genes DJ Mazur, FW Perrino Journal of Biological Chemistry 276 (18), 14718-14727, 2001 | 100 | 2001 |
| Lesion bypass of N2-ethylguanine by human DNA polymerase ι MG Pence, P Blans, CN Zink, T Hollis, JC Fishbein, FW Perrino Journal of biological chemistry 284 (3), 1732-1740, 2009 | 88 | 2009 |
| Mammalian DNA Polymerases. alpha.,. beta.,. gamma.,. delta., and. epsilon. Incorporate Fialuridine (FIAU) Monophosphate into DNA and Are Inhibited Competitively by FIAU … W Lewis, RR Meyer, JF Simpson, JM Colacino, FW Perrino Biochemistry 33 (48), 14620-14624, 1994 | 86* | 1994 |
| Dominant mutations of the TREX1 exonuclease gene in lupus and Aicardi-Goutières syndrome JM Fye, CD Orebaugh, SR Coffin, T Hollis, FW Perrino Journal of Biological Chemistry 286 (37), 32373-32382, 2011 | 83 | 2011 |
| The human TREX2 3′→ 5′-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis FW Perrino, S Harvey, S McMillin, T Hollis Journal of Biological Chemistry 280 (15), 15212-15218, 2005 | 77 | 2005 |
