Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β C Manca, L Tsenova, A Bergtold, S Freeman, M Tovey, JM Musser, ... Proceedings of the National Academy of Sciences 98 (10), 5752-5757, 2001 | 771 | 2001 |
Metformin as adjunct antituberculosis therapy A Singhal, L Jie, P Kumar, GS Hong, MKS Leow, B Paleja, L Tsenova, ... Science translational medicine 6 (263), 263ra159-263ra159, 2014 | 541 | 2014 |
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism MJ Kim, HC Wainwright, M Locketz, LG Bekker, GB Walther, C Dittrich, ... EMBO molecular medicine 2 (7), 258-274, 2010 | 514 | 2010 |
Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates C Manca, L Tsenova, CE Barry, A Bergtold, S Freeman, PAJ Haslett, ... The journal of immunology 162 (11), 6740-6746, 1999 | 407 | 1999 |
Hypervirulent M. tuberculosis W/Beijing Strains Upregulate Type I IFNs and Increase Expression of Negative Regulators of the Jak-Stat Pathway C Manca, L Tsenova, S Freeman, AK Barczak, M Tovey, PJ Murray, ... Journal of Interferon & Cytokine Research 25 (11), 694-701, 2005 | 376 | 2005 |
The resuscitation‐promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro BD Kana, BG Gordhan, KJ Downing, N Sung, G Vostroktunova, ... Molecular microbiology 67 (3), 672-684, 2008 | 372 | 2008 |
Virulence of Selected Mycobacterium tuberculosis Clinical Isolates in the Rabbit Model of Meningitis Is Dependent on Phenolic Glycolipid Produced by the Bacilli L Tsenova, E Ellison, R Harbacheuski, AL Moreira, N Kurepina, MB Reed, ... The Journal of infectious diseases 192 (1), 98-106, 2005 | 326 | 2005 |
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients J Timm, FA Post, LG Bekker, GB Walther, HC Wainwright, R Manganelli, ... Proceedings of the National Academy of Sciences 100 (24), 14321-14326, 2003 | 324 | 2003 |
Tumor necrosis factor α is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system L Tsenova, A Bergtold, VH Freedman, RA Young, G Kaplan Proceedings of the National Academy of Sciences 96 (10), 5657-5662, 1999 | 238 | 1999 |
A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death L Tsenova, K Sokol, HF Victoria, G Kaplan Journal of Infectious Diseases 177 (6), 1563-1572, 1998 | 187 | 1998 |
The Phenolic Glycolipid of Mycobacterium tuberculosis Differentially Modulates the Early Host Cytokine Response but Does Not in Itself Confer Hypervirulence D Sinsimer, G Huet, C Manca, L Tsenova, MS Koo, N Kurepina, B Kana, ... Infection and immunity 76 (7), 3027-3036, 2008 | 169 | 2008 |
Mycobacterial Antigens Exacerbate Disease Manifestations in Mycobacterium tuberculosis-Infected Mice AL Moreira, L Tsenova, M Haile Aman, LG Bekker, S Freeman, ... Infection and immunity 70 (4), 2100-2107, 2002 | 130 | 2002 |
Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response S Subbian, L Tsenova, G Yang, P O'Brien, S Parsons, B Peixoto, L Taylor, ... Open Biology 1 (4), 110016, 2011 | 124 | 2011 |
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents a therapeutic target against tuberculosis CY Cheng, NM Gutierrez, MB Marzuki, X Lu, TW Foreman, B Paleja, ... Science immunology 2 (9), eaaj1789, 2017 | 107 | 2017 |
Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs S Subbian, L Tsenova, P O'Brien, G Yang, MS Koo, B Peixoto, D Fallows, ... PLoS pathogens 7 (9), e1002262, 2011 | 102 | 2011 |
Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology S Subbian, L Tsenova, P O'Brien, G Yang, MS Koo, B Peixoto, D Fallows, ... The American journal of pathology 179 (1), 289-301, 2011 | 101 | 2011 |
Ribonucleotide Reduction in Mycobacterium tuberculosis: Function and Expression of Genes Encoding Class Ib and Class II Ribonucleotide Reductases SS Dawes, DF Warner, L Tsenova, J Timm, JD McKinney, G Kaplan, ... Infection and immunity 71 (11), 6124-6131, 2003 | 100 | 2003 |
Lesion-specific immune response in granulomas of patients with pulmonary tuberculosis: a pilot study S Subbian, L Tsenova, MJ Kim, HC Wainwright, A Visser, ... PLoS One 10 (7), e0132249, 2015 | 95 | 2015 |
BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system disease L Tsenova, R Harbacheuski, N Sung, E Ellison, D Fallows, G Kaplan Vaccine 25 (28), 5126-5132, 2007 | 92 | 2007 |
Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits S Subbian, N Bandyopadhyay, L Tsenova, P O’Brien, V Khetani, ... Cell Communication and Signaling 11, 1-17, 2013 | 91 | 2013 |