| PI3K signaling in cancer: beyond AKT EC Lien, CC Dibble, A Toker Current opinion in cell biology 45, 62-71, 2017 | 447 | 2017 |
| Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ... Cell 164 (3), 433-446, 2016 | 351 | 2016 |
| Glutathione biosynthesis is a metabolic vulnerability in PI (3) K/Akt-driven breast cancer EC Lien, CA Lyssiotis, A Juvekar, H Hu, JM Asara, LC Cantley, A Toker Nature cell biology 18 (5), 572-578, 2016 | 245 | 2016 |
| Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth AG Cox, KL Hwang, KK Brown, KJ Evason, S Beltz, A Tsomides, ... Nature cell biology 18 (8), 886-896, 2016 | 203 | 2016 |
| MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis BG Cuiffo, A Campagne, GW Bell, A Lembo, F Orso, EC Lien, MK Bhasin, ... Cell stem cell 15 (6), 762-774, 2014 | 195 | 2014 |
| Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer EC Lien, CA Lyssiotis, LC Cantley Metabolism in Cancer, 39-72, 2016 | 194 | 2016 |
| Low glycaemic diets alter lipid metabolism to influence tumour growth EC Lien, AM Westermark, Y Zhang, C Yuan, Z Li, AN Lau, KM Sapp, ... Nature 599 (7884), 302-307, 2021 | 166 | 2021 |
| Altered exocrine function can drive adipose wasting in early pancreatic cancer LV Danai, A Babic, MH Rosenthal, EA Dennstedt, A Muir, EC Lien, ... Nature 558 (7711), 600-604, 2018 | 129 | 2018 |
| A framework for examining how diet impacts tumour metabolism EC Lien, MG Vander Heiden Nature Reviews Cancer 19 (11), 651-661, 2019 | 107 | 2019 |
| Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt J Zhang, K Xu, P Liu, Y Geng, B Wang, W Gan, J Guo, F Wu, YR Chin, ... Molecular cell 62 (6), 929-942, 2016 | 104 | 2016 |
| Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion A Juvekar, H Hu, S Yadegarynia, CA Lyssiotis, S Ullas, EC Lien, ... Proceedings of the National Academy of Sciences 113 (30), E4338-E4347, 2016 | 97 | 2016 |
| Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth AG Cox, A Tsomides, D Yimlamai, KL Hwang, J Miesfeld, GG Galli, ... The EMBO journal 37 (22), e100294, 2018 | 84 | 2018 |
| Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT EC Lien, L Ghisolfi, RC Geck, JM Asara, A Toker Science signaling 10 (510), eaao6604, 2017 | 80 | 2017 |
| Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma AN Lau, Z Li, LV Danai, AM Westermark, AM Darnell, R Ferreira, ... Elife 9, e56782, 2020 | 70 | 2020 |
| Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis AG Cox, A Tsomides, AJ Kim, D Saunders, KL Hwang, KJ Evason, ... Proceedings of the National Academy of Sciences 113 (38), E5562-E5571, 2016 | 68 | 2016 |
| The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis K Shimizu, H Fukushima, K Ogura, EC Lien, NT Nihira, J Zhang, BJ North, ... Science signaling 10 (460), eaah4117, 2017 | 51 | 2017 |
| REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks N Chatterjee, MA Whitman, CA Harris, SM Min, O Jonas, EC Lien, ... Proceedings of the National Academy of Sciences 117 (46), 28918-28921, 2020 | 32 | 2020 |
| Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression V Gouirand, T Gicquel, EC Lien, E Jaune‐Pons, Q Da Costa, P Finetti, ... The EMBO Journal 41 (9), e110466, 2022 | 29 | 2022 |
| Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited Z Li, BW Ji, PD Dixit, EC Lien, K Tchourine, AM Hosios, KL Abbott, ... bioRxiv, 2020 | 27 | 2020 |
| Oncogenic AKT1 (E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis ML Mancini, EC Lien, A Toker Oncotarget 7 (14), 17301, 2016 | 27 | 2016 |
