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Cristina Mayor-Ruiz
Cristina Mayor-Ruiz
Principal Investigator at IRB Barcelona
Verified email at irbbarcelona.org
Title
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Year
Rational discovery of molecular glue degraders via scalable chemical profiling
C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ...
Nature chemical biology 16 (11), 1199-1207, 2020
2232020
A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors
S Ruiz, C Mayor-Ruiz, V Lafarga, M Murga, M Vega-Sendino, S Ortega, ...
Molecular cell 62 (2), 307-313, 2016
1962016
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
GE Winter, B Radic, C Mayor-Ruiz, VA Blomen, C Trefzer, RK Kandasamy, ...
Nature chemical biology 10 (9), 768-773, 2014
1752014
Plasticity of the Cullin-RING ligase repertoire shapes sensitivity to ligand-induced protein degradation
C Mayor-Ruiz, MG Jaeger, S Bauer, M Brand, C Sin, A Hanzl, AC Mueller, ...
Molecular cell 75 (4), 849-858. e8, 2019
832019
A p53-dependent response limits the viability of mammalian haploid cells
T Olbrich, C Mayor-Ruiz, M Vega-Sendino, C Gomez, S Ortega, S Ruiz, ...
Proceedings of the National Academy of Sciences 114 (35), 9367-9372, 2017
772017
Chasing molecular glue degraders: screening approaches
A Domostegui, L Nieto-Barrado, C Perez-Lopez, C Mayor-Ruiz
Chemical Society Reviews 51 (13), 5498-5517, 2022
632022
Identification and selectivity profiling of small-molecule degraders via multi-omics approaches
NS Scholes, C Mayor-Ruiz, GE Winter
Cell Chemical Biology 28 (7), 1048-1060, 2021
362021
Identification and characterization of cancer vulnerabilities via targeted protein degradation
C Mayor-Ruiz, GE Winter
Drug Discovery Today: Technologies 31, 81-90, 2019
322019
ERF deletion rescues RAS deficiency in mouse embryonic stem cells
C Mayor-Ruiz, T Olbrich, M Drosten, E Lecona, M Vega-Sendino, ...
Genes & Development 32 (7-8), 568-576, 2018
142018
Design principles for cyclin K molecular glue degraders
Z Kozicka, DJ Suchyta, V Focht, G Kempf, G Petzold, M Jentzsch, C Zou, ...
Nature Chemical Biology 20 (1), 93-102, 2024
132024
Biophysical and computational approaches to study ternary complexes: a ‘cooperative relationship’to rationalize targeted protein degradation
JA Ward, C Perez‐Lopez, C Mayor‐Ruiz
ChemBioChem 24 (10), e202300163, 2023
132023
TrapSeq: An RNA sequencing-based pipeline for the identification of gene-trap insertions in mammalian cells
C Mayor-Ruiz, O Dominguez, O Fernandez-Capetillo
Journal of molecular biology 429 (18), 2780-2789, 2017
112017
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
L González, L Díaz, J Pous, B Baginski, A Duran-Corbera, M Scarpa, ...
Nature Communications 14 (1), 3318, 2023
62023
Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling
C Mayor-Ruiz, S Bauer, M Brand, Z Kozicka, M Siklos, H Imrichova, ...
Nature Chemical Biology 17 (3), 361-361, 2021
52021
Molecular Glue Degraders: From Serendipity to Hunting and Design
L Nieto‐Barrado, A Domostegui, C Mayor‐Ruiz
Inducing Targeted Protein Degradation: From Chemical Biology to Drug …, 2023
22023
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP
M Cigler, H Imrichova, F Frommelt, L Depta, A Rukavina, C Kagiou, ...
bioRxiv, 2023.03. 15.532743, 2023
12023
Inside Cover: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. Int. Ed. 12/2024)
BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ...
Angewandte Chemie International Edition 63 (12), e202403450, 2024
2024
Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024)
BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ...
Angewandte Chemie 136 (12), e202403450, 2024
2024
Chemical rewiring of ubiquitination by degraders and their selectivity routes
R Whelan, C Mayor-Ruiz
Nature Structural & Molecular Biology 31 (2), 205-207, 2024
2024
Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders
BMG Barbosa, A Sfyaki, S Rafael, F José‐Duran, J Pous, ...
Angewandte Chemie International Edition, e202316730, 2024
2024
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