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David W. Borhani
David W. Borhani
Ginkgo Bioworks, Inc.
Email verificata su alum.mit.edu
Titolo
Citata da
Citata da
Anno
Pathway and mechanism of drug binding to G-protein-coupled receptors
RO Dror, AC Pan, DH Arlow, DW Borhani, P Maragakis, Y Shan, H Xu, ...
Proceedings of the National Academy of Sciences 108 (32), 13118-13123, 2011
8032011
Mechanism of voltage gating in potassium channels
MO Jensen, V Jogini, DW Borhani, AE Leffler, RO Dror, DE Shaw
Science 336 (6078), 229, 2012
6392012
Activation mechanism of the β2-adrenergic receptor
RO Dror, DH Arlow, P Maragakis, TJ Mildorf, AC Pan, H Xu, DW Borhani, ...
Proceedings of the National Academy of Sciences 108 (46), 18684-18689, 2011
6282011
Crystal structure of truncated human apolipoprotein AI suggests a lipid-bound conformation
DW Borhani, DP Rogers, JA Engler, CG Brouillette
Proceedings of the National Academy of Sciences 94 (23), 12291-12296, 1997
5961997
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
RO Dror, HF Green, C Valant, DW Borhani, JR Valcourt, AC Pan, ...
Nature 503 (7475), 295-299, 2013
4322013
Crystal structure of the ectodomain of human transferrin receptor
CM Lawrence, S Ray, M Babyonyshev, R Galluser, DW Borhani, ...
Science 286 (5440), 779-782, 1999
4231999
Molecular determinants of drug–receptor binding kinetics
AC Pan, DW Borhani, RO Dror, DE Shaw
Drug discovery today 18 (13-14), 667-673, 2013
4032013
Identification Of Two Distinct Inactive Conformations Of The Beta-2 Adrenergic Receptor Reconciles Structural And Biochemical Observations
RO Dror, DH Arlow, DW Borhani, M Jensen, DE Shaw
Biophysical Journal 96 (3), 365a, 2009
3742009
Principles of conduction and hydrophobic gating in K+ channels
MØ Jensen, DW Borhani, K Lindorff-Larsen, P Maragakis, V Jogini, ...
Proceedings of the National Academy of Sciences 107 (13), 5833-5838, 2010
3662010
The future of molecular dynamics simulations in drug discovery
DW Borhani, DE Shaw
Journal of computer-aided molecular design 26, 15-26, 2012
3632012
Structural models of human apolipoprotein AI: a critical analysis and review
CG Brouillette, GM Anantharamaiah, JA Engler, DW Borhani
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2001
3482001
Structural basis for nucleotide exchange in heterotrimeric G proteins
RO Dror, TJ Mildorf, D Hilger, A Manglik, DW Borhani, DH Arlow, ...
Science 348 (6241), 1361-1365, 2015
3122015
Crystalline anti-hTNFalpha antibodies
DW Borhani, W Fraunhofer, HJ Krause, A Koenigsdorfer, G Winter, ...
US Patent 8,034,906, 2011
2492011
Exploring atomic resolution physiology on a femtosecond to millisecond timescale using molecular dynamics simulations
RO Dror, MØ Jensen, DW Borhani, DE Shaw
Journal of General Physiology 135 (6), 555-562, 2010
1942010
Compositions and methods for crystallizing antibodies
W Fraunhofer, DW Borhani, G Winter, S Gottschalk
US Patent 8,753,839, 2014
1732014
The crystal structure of the aldose reductase. NADPH binary complex.
DW Borhani, TM Harter, JM Petrash
Journal of Biological Chemistry 267 (34), 24841-24847, 1992
1611992
Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.
I Tarle, DW Borhani, DK Wilson, FA Quiocho, JM Petrash
Journal of Biological Chemistry 268 (34), 25687-25693, 1993
1551993
Slow Polymerization of Mycobacterium tuberculosis FtsZ
EL White, LJ Ross, RC Reynolds, LE Seitz, GD Moore, DW Borhani
Journal of Bacteriology 182 (14), 4028-4034, 2000
1482000
A high yield purification of the human transferrin receptor and properties of its major extracellular fragment.
AP Turkewitz, JF Amatruda, D Borhani, SC Harrison, AL Schwartz
Journal of Biological Chemistry 263 (17), 8318-8325, 1988
1401988
Structure of<i> Mycobacterium tuberculosis</i> FtsZ Reveals Unexpected, G Protein-like Conformational Switches
AKW Leung, E Lucile White, LJ Ross, RC Reynolds, JA DeVito, ...
Journal of molecular biology 342 (3), 953-970, 2004
1382004
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