| Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody RNN Abskharon, G Giachin, A Wohlkonig, SH Soror, E Pardon, ... Journal of the American Chemical Society 136 (3), 937-944, 2014 | 131 | 2014 |
| Dynamics of human mitochondrial complex I assembly: implications for neurodegenerative diseases G Giachin, R Bouverot, S Acajjaoui, S Pantalone, M Soler-López Frontiers in molecular biosciences 3, 43, 2016 | 114 | 2016 |
| NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features G Ilc, G Giachin, M Jaremko, Ł Jaremko, F Benetti, J Plavec, I Zhukov, ... PloS one 5 (7), e11715, 2010 | 110 | 2010 |
| In vitro aggregation assays for the characterization of α-synuclein prion-like properties J Narkiewicz, G Giachin, G Legname Prion 8 (1), 19-32, 2014 | 100 | 2014 |
| Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation I Biljan, G Ilc, G Giachin, A Raspadori, I Zhukov, J Plavec, G Legname Journal of molecular biology 412 (4), 660-673, 2011 | 86 | 2011 |
| Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism I Biljan, G Giachin, G Ilc, I Zhukov, J Plavec, G Legname Biochemical Journal 446 (2), 243-251, 2012 | 74 | 2012 |
| Structural facets of disease‐linked human prion protein mutants: a molecular dynamic study G Rossetti, G Giachin, G Legname, P Carloni Proteins: Structure, Function, and Bioinformatics 78 (16), 3270-3280, 2010 | 65 | 2010 |
| Structural consequences of copper binding to the prion protein G Salzano, G Giachin, G Legname Cells 8 (8), 770, 2019 | 55 | 2019 |
| Characterization of prion protein function by focal neurite stimulation L Amin, XTA Nguyen, IG Rolle, E D'Este, G Giachin, TH Tran, VČ Šerbec, ... Journal of Cell Science 129 (20), 3878-3891, 2016 | 52 | 2016 |
| Probing early misfolding events in prion protein mutants by NMR spectroscopy G Giachin, I Biljan, G Ilc, J Plavec, G Legname Molecules 18 (8), 9451-9476, 2013 | 46 | 2013 |
| The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion G Giachin, PT Mai, TH Tran, G Salzano, F Benetti, V Migliorati, A Arcovito, ... Scientific reports 5 (1), 15253, 2015 | 45 | 2015 |
| Structural rearrangements at physiological pH: nuclear magnetic resonance insights from the V210I human prion protein mutant I Biljan, G Ilc, G Giachin, J Plavec, G Legname Biochemistry 51 (38), 7465-7474, 2012 | 45 | 2012 |
| The N terminus of the prion protein mediates functional interactions with the neuronal cell adhesion molecule (NCAM) fibronectin domain U Slapšak, G Salzano, L Amin, RNN Abskharon, G Ilc, B Zupančič, I Biljan, ... Journal of Biological Chemistry 291 (42), 21857-21868, 2016 | 41 | 2016 |
| Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins L Qin, FB Bdira, YGJ Sterckx, AN Volkov, J Vreede, G Giachin, ... Nucleic acids research 48 (4), 2156-2172, 2020 | 39 | 2020 |
| Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site P D’Angelo, S Della Longa, A Arcovito, G Mancini, A Zitolo, G Chillemi, ... Biochemistry 51 (31), 6068-6079, 2012 | 37 | 2012 |
| Structural determinants in prion protein folding and stability F Benetti, X Biarnés, F Attanasio, G Giachin, E Rizzarelli, G Legname Journal of molecular biology 426 (22), 3796-3810, 2014 | 33 | 2014 |
| Epitope mapping of a PrP (Sc)-specific monoclonal antibody: identification of a novel C-terminally truncated prion fragment M Kosmač, S Koren, G Giachin, T Stoilova, R Gennaro, G Legname, ... Molecular immunology 48 (5), 746-750, 2011 | 30 | 2011 |
| Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion R Abskharon, F Wang, A Wohlkonig, J Ruan, S Soror, G Giachin, ... PLoS Pathogens 15 (12), e1008139, 2019 | 29 | 2019 |
| A novel expression system for production of soluble prion proteins in E. coli RNN Abskharon, S Ramboarina, H El Hassan, W Gad, MI Apostol, ... Microbial Cell Factories 11, 1-11, 2012 | 28 | 2012 |
| Prion protein interaction with soil humic substances: environmental implications G Giachin, J Narkiewicz, D Scaini, AT Ngoc, A Margon, P Sequi, L Leita, ... PLoS One 9 (6), e100016, 2014 | 26 | 2014 |
Giuseppe LegnameProfessor of Biochemistry - SISSA - UCSF - NIMR/MRCVerified email at sissa.it
