| Photoreactive analogues of prenyl diphosphates as inhibitors and probes of human protein farnesyltransferase and geranylgeranyltransferase type I YE Bukhtiyarov, CA Omer, CM Allen Journal of Biological Chemistry 270 (32), 19035-19040, 1995 | 73 | 1995 |
| Structure-based design and synthesis of 1, 3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Z Xu, CM Tice, W Zhao, S Cacatian, YJ Ye, SB Singh, P Lindblom, ... Journal of medicinal chemistry 54 (17), 6050-6062, 2011 | 45 | 2011 |
| Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility L Jia, RD Simpson, J Yuan, Z Xu, W Zhao, S Cacatian, CM Tice, J Guo, ... ACS Medicinal Chemistry Letters 2 (10), 747-751, 2011 | 41 | 2011 |
| Three-dimensional placement of the conserved 530 loop of 16 S rRNA and of its neighboring components in the 30 S subunit R Wang, RW Alexander, M VanLoock, S Vladimirov, Y Bukhtiyarov, ... Journal of molecular biology 286 (2), 521-540, 1999 | 40 | 1999 |
| Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design CM Tice, W Zhao, Z Xu, ST Cacatian, RD Simpson, YJ Ye, SB Singh, ... Bioorganic & medicinal chemistry letters 20 (3), 881-886, 2010 | 32 | 2010 |
| Discovery of a novel, orally efficacious liver X receptor (LXR) β agonist Y Zheng, L Zhuang, KY Fan, CM Tice, W Zhao, C Dong, SD Lotesta, ... Journal of Medicinal Chemistry 59 (7), 3264-3271, 2016 | 30 | 2016 |
| Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors PB Noto, Y Bukhtiyarov, M Shi, BM McKeever, GM McGeehan, DS Lala Molecular pharmacology 82 (4), 719-727, 2012 | 28 | 2012 |
| Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists SD Lotesta, AP Marcus, Y Zheng, K Leftheris, PB Noto, S Meng, ... Bioorganic & Medicinal Chemistry 24 (6), 1384-1391, 2016 | 26 | 2016 |
| Design and optimization of renin inhibitors: Orally bioavailable alkyl amines CM Tice, Z Xu, J Yuan, RD Simpson, ST Cacatian, PT Flaherty, W Zhao, ... Bioorganic & medicinal chemistry letters 19 (13), 3541-3545, 2009 | 23 | 2009 |
| Optimization of orally bioavailable alkyl amine renin inhibitors Z Xu, S Cacatian, J Yuan, RD Simpson, L Jia, W Zhao, CM Tice, ... Bioorganic & medicinal chemistry letters 20 (2), 694-699, 2010 | 22 | 2010 |
| Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor L Zhuang, CM Tice, Z Xu, W Zhao, S Cacatian, YJ Ye, SB Singh, ... Bioorganic & Medicinal Chemistry 25 (14), 3649-3657, 2017 | 19 | 2017 |
| Inhibitors of β-secretase Y Bukhtiyarov, S Cacatian, LW Dillard, C Dorner-Ciossek, K Fuchs, L Jia, ... US Patent 8,981,112, 2015 | 19 | 2015 |
| Identification of inhibitors of bacterial transcription/translation machinery utilizing a miniaturized 1536-well format screen I Kariv, H Cao, PD Marvil, EV Bobkova, YE Bukhtiyarov, YP Yan, U Patel, ... Journal of Biomolecular Screening 6 (4), 233-243, 2001 | 18 | 2001 |
| Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1 CM Tice, W Zhao, PM Krosky, BA Kruk, J Berbaum, JA Johnson, ... Bioorganic & medicinal chemistry letters 20 (22), 6725-6729, 2010 | 15 | 2010 |
| Solubilization and Characterization of Dehydrodolichy Diphosphate Synthase from the Yeast Saccharomoyces Carlsbergensis YE Bukhtiyarov, YA Shabalin, IS Kulaev The Journal of Biochemistry 113 (6), 721-728, 1993 | 13 | 1993 |
| Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket J Yuan, RD Simpson, W Zhao, CM Tice, Z Xu, S Cacatian, L Jia, ... Bioorganic & medicinal chemistry letters 21 (16), 4836-4843, 2011 | 12 | 2011 |
| Brain penetrant liver X receptor (LXR) modulators based on a 2, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazole core CM Tice, PB Noto, KY Fan, W Zhao, SD Lotesta, C Dong, AP Marcus, ... Bioorganic & Medicinal Chemistry Letters 26 (20), 5044-5050, 2016 | 10 | 2016 |
| Purification and characterization of recombinant human renin for X-ray crystallization studies Z Wu, MG Cappiello, BB Scott, Y Bukhtiyarov, GM McGeehan BMC biochemistry 9, 1-7, 2008 | 10 | 2008 |
| In vitro and in vivo assessment of the potential of supersaturation to enhance the absorption of poorly soluble basic drugs J Li, Y Bukhtiyarov, N Spivey, C Force, C Hidalgo, Y Huang, AJ Owen, ... Journal of Pharmaceutical Innovation 15, 591-602, 2020 | 9 | 2020 |
| Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers GM McGeehan, SA Palmer, CC Bryson, Y Zhao, M Shi, KK Lipinski, ... The Journal of Immunology 196 (1_Supplement), 71.4-71.4, 2016 | 7 | 2016 |
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