| A central role for RAF→ MEK→ ERK signaling in the genesis of pancreatic ductal adenocarcinoma EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ... Cancer discovery 2 (8), 685-693, 2012 | 334 | 2012 |
| The epidermal barrier function is dependent on the serine protease CAP1/Prss8 C Leyvraz, RP Charles, I Rubera, M Guitard, S Rotman, B Breiden, ... The Journal of cell biology 170 (3), 487-496, 2005 | 312 | 2005 |
| Transient and selective NF-κB p65 serine 536 phosphorylation induced by T cell costimulation is mediated by IκB kinase β and controls the kinetics of p65 nuclear import I Mattioli, A Sebald, C Bucher, RP Charles, H Nakano, M Kracht, ... The Journal of Immunology 172 (10), 6336-6344, 2004 | 285 | 2004 |
| The L-type amino acid transporter LAT1—An emerging target in cancer P Häfliger, RP Charles International journal of molecular sciences 20 (10), 2428, 2019 | 177 | 2019 |
| Mutationally activated BRAFV600E elicits papillary thyroid cancer in the adult mouse RP Charles, G Iezza, E Amendola, D Dankort, M McMahon Cancer research 71 (11), 3863-3871, 2011 | 120 | 2011 |
| Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis RP Charles, J Silva, G Iezza, WA Phillips, M McMahon Molecular Cancer Research 12 (7), 979-986, 2014 | 119 | 2014 |
| PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin S Frateschi, E Camerer, G Crisante, S Rieser, M Membrez, RP Charles, ... Nature communications 2 (1), 161, 2011 | 112 | 2011 |
| ENaC‐mediated alveolar fluid clearance and lung fluid balance depend on the channel‐activating protease 1 C Planès, NH Randrianarison, RP Charles, S Frateschi, F Cluzeaud, ... EMBO molecular medicine 2 (1), 26-37, 2009 | 99 | 2009 |
| Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake A Chicca, S Nicolussi, R Bartholomäus, M Blunder, A Aparisi Rey, ... Proceedings of the National Academy of Sciences 114 (25), E5006-E5015, 2017 | 98 | 2017 |
| Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3 S Boulkroun, D Ruffieux-Daidié, JJ Vitagliano, O Poirot, RP Charles, ... American Journal of Physiology-Renal Physiology 295 (4), F889-F900, 2008 | 91 | 2008 |
| The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model P Häfliger, J Graff, M Rubin, A Stooss, MS Dettmer, KH Altmann, J Gertsch, ... Journal of experimental & clinical cancer research 37, 1-15, 2018 | 83 | 2018 |
| The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes H Yang, RP Charles, E Hummler, DL Baines, RR Isseroff Journal of cell science 126 (9), 1942-1951, 2013 | 79 | 2013 |
| Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance S Malsure, Q Wang, RP Charles, C Sergi, R Perrier, BM Christensen, ... Journal of the American Society of Nephrology 25 (7), 1453-1464, 2014 | 77 | 2014 |
| E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor CY Li, W Cha, HU Luder, RP Charles, M McMahon, TA Mitsiadis, ... Developmental biology 366 (2), 357-366, 2012 | 68 | 2012 |
| Targeting CD47 in anaplastic thyroid carcinoma enhances tumor phagocytosis by macrophages and is a promising therapeutic strategy CM Schürch, MA Roelli, S Forster, MH Wasmer, F Brühl, RS Maire, ... Thyroid 29 (7), 979-992, 2019 | 67 | 2019 |
| Optimization of TRPV6 calcium channel inhibitors using a 3D ligand‐based virtual screening method C Simonin, M Awale, M Brand, R Van Deursen, J Schwartz, M Fine, ... Angewandte Chemie International Edition 54 (49), 14748-14752, 2015 | 53 | 2015 |
| Postnatal requirement of the epithelial sodium channel for maintenance of epidermal barrier function RP Charles, M Guitard, C Leyvraz, B Breiden, M Haftek, Z Haftek-Terreau, ... Journal of biological chemistry 283 (5), 2622-2630, 2008 | 49 | 2008 |
| The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation E Hummler, A Dousse, A Rieder, JC Stehle, I Rubera, MC Osterheld, ... PloS one 8 (2), e55796, 2013 | 34 | 2013 |
| Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo O ElMokh, D Ruffieux-Daidié, MA Roelli, A Stooss, WA Phillips, J Gertsch, ... Oncotarget 8 (15), 24604, 2017 | 28 | 2017 |
| 4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation A Chicca, MS Gachet, V Petrucci, W Schuehly, RP Charles, J Gertsch Journal of neuroinflammation 12, 1-16, 2015 | 28 | 2015 |
Martin McMahonCumming-Presidential Professor of Cancer Biology, Huntsman Cancer Institute, Univ. of UtahVerified email at hci.utah.edu
