| muma, an R package for metabolomics univariate and multivariate statistical analysis E Gaude, F Chignola, D Spiliotopoulos, A Spitaleri, M Ghitti, ... Current Metabolomics 1 (2), 180-189, 2013 | 105 | 2013 |
| GMXPBSA 2.1: A GROMACS tool to perform MM/PBSA and computational alanine scanning. C Paissoni, D Spiliotopoulos, G Musco, A Spitaleri Comput. Phys. Commun. 186 (Supplement C), 105-107, 2015 | 100 | 2015 |
| Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study D Spiliotopoulos, A Spitaleri, G Musco Public Library of Science 7 (10), e46902, 2012 | 97 | 2012 |
| An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population D Spiliotopoulos, D Goffredo, L Conti, F Di Febo, G Biella, M Toselli, ... Neurobiology of disease 34 (2), 320-331, 2009 | 86 | 2009 |
| Discovery of CREBBP bromodomain inhibitors by high-throughput docking and hit optimization guided by molecular dynamics M Xu, A Unzue, J Dong, D Spiliotopoulos, C Nevado, A Caflisch Journal of medicinal chemistry 59 (4), 1340-1349, 2016 | 80 | 2016 |
| Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking H Zhao, L Gartenmann, J Dong, D Spiliotopoulos, A Caflisch Bioorganic & medicinal chemistry letters 24 (11), 2493-2496, 2014 | 73 | 2014 |
| dMM-PBSA: a new HADDOCK scoring function for protein-peptide docking D Spiliotopoulos, PL Kastritis, ASJ Melquiond, AMJJ Bonvin, G Musco, ... Frontiers in molecular biosciences 3, 46, 2016 | 69 | 2016 |
| Fragment-based design of selective nanomolar ligands of the CREBBP bromodomain A Unzue, M Xu, J Dong, L Wiedmer, D Spiliotopoulos, A Caflisch, ... Journal of medicinal chemistry 59 (4), 1350-1356, 2016 | 66 | 2016 |
| GMXPBSA 2.0: A GROMACS tool to perform MM/PBSA and computational alanine scanning C Paissoni, D Spiliotopoulos, G Musco, A Spitaleri Computer Physics Communications 185 (11), 2920-2929, 2014 | 45 | 2014 |
| AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome M Gaetani, V Matafora, M Saare, D Spiliotopoulos, L Mollica, G Quilici, ... Nucleic acids research 40 (22), 11756-11768, 2012 | 45 | 2012 |
| Chemical space expansion of bromodomain ligands guided by in silico virtual couplings (AutoCouple) L Batiste, A Unzue, A Dolbois, F Hassler, X Wang, N Deerain, J Zhu, ... ACS central science 4 (2), 180-188, 2018 | 31 | 2018 |
| Discovery of BAZ2A bromodomain ligands D Spiliotopoulos, EC Wamhoff, G Lolli, C Rademacher, A Caflisch European journal of medicinal chemistry 139, 564-572, 2017 | 23 | 2017 |
| Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain D Spiliotopoulos, J Zhu, EC Wamhoff, N Deerain, JR Marchand, J Aretz, ... Bioorganic & medicinal chemistry letters 27 (11), 2472-2478, 2017 | 22 | 2017 |
| Molecular Dynamics Simulations of Bromodomains Reveal Binding‐Site Flexibility and Multiple Binding Modes of the Natural Ligand Acetyl‐Lysine D Spiliotopoulos, A Caflisch Israel Journal of Chemistry 54 (8‐9), 1084-1092, 2014 | 19 | 2014 |
| Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases J Dong, H Zhao, T Zhou, D Spiliotopoulos, C Rajendran, XD Li, D Huang, ... ACS medicinal chemistry letters 6 (1), 79-83, 2015 | 17 | 2015 |
| Fragment-based in silico screening of bromodomain ligands D Spiliotopoulos, A Caflisch Drug Discovery Today: Technologies 19, 81-90, 2016 | 15 | 2016 |
| Structural analysis of small‐molecule binding to the BAZ2A and BAZ2B Bromodomains A Dalle Vedove, D Spiliotopoulos, VG D'Agostino, JR Marchand, A Unzue, ... ChemMedChem 13 (14), 1479-1487, 2018 | 14 | 2018 |
| Structural basis for PHDVC5HCHNSD1–C2HRNizp1 interaction: implications for Sotos syndrome A Berardi, G Quilici, D Spiliotopoulos, MA Corral-Rodriguez, ... Nucleic acids research 44 (7), 3448-3463, 2016 | 14 | 2016 |
| A DNA transposon-based approach to functional screening in neural stem cells I Albieri, M Onorati, G Calabrese, A Moiana, D Biasci, A Badaloni, ... Journal of biotechnology 150 (1), 11-21, 2010 | 11 | 2010 |
| Muma: Metabolomics Univariate and Multivariate Analysis E Gaude, F Chignola, D Spiliotopoulos, S Mari, A Spitaleri, M Ghitti R package version 1, 2012 | 10 | 2012 |
Amedeo CaflischDepartment of Biochemistry, University of ZurichEmail verificata su bioc.uzh.ch
