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Alexey "Alex" Lugovskoy
Alexey "Alex" Lugovskoy
EIR, Atlas Venture
Email verificata su lugovskoy.org
Titolo
Citata da
Citata da
Anno
Identification of RIP1 kinase as a specific cellular target of necrostatins
A Degterev, J Hitomi, M Germscheid, IL Ch'en, O Korkina, X Teng, ...
Nature chemical biology 4 (5), 313-321, 2008
21182008
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
A Degterev, A Lugovskoy, M Cardone, B Mulley, G Wagner, T Mitchison, ...
Nature cell biology 3 (2), 173-182, 2001
8032001
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
O Gozani, P Karuman, DR Jones, D Ivanov, J Cha, AA Lugovskoy, ...
Cell 114 (1), 99-111, 2003
6332003
Small-molecule inhibition of TNF-α
MM He, AS Smith, JD Oslob, WM Flanagan, AC Braisted, A Whitty, ...
Science 310 (5750), 1022-1025, 2005
5652005
Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E
JD Gross, NJ Moerke, T von der Haar, AA Lugovskoy, AB Sachs, ...
Cell 115 (6), 739-750, 2003
4352003
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or …
X Shi, I Kachirskaia, KL Walter, JHA Kuo, A Lake, F Davrazou, SM Chan, ...
Journal of Biological Chemistry 282 (4), 2450-2455, 2007
3072007
Identification and characterization of mefloquine efficacy against JC virus in vitro
M Brickelmaier, A Lugovskoy, R Kartikeyan, MM Reviriego-Mendoza, ...
Antimicrobial agents and chemotherapy 53 (5), 1840-1849, 2009
2522009
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
D Marcotte, W Zeng, JC Hus, A McKenzie, C Hession, P Jin, C Bergeron, ...
Bioorganic & medicinal chemistry 21 (14), 4011-4019, 2013
2402013
Affinity enhancement of an in vivo matured therapeutic antibody using structure‐based computational design
LA Clark, PA Boriack‐Sjodin, J Eldredge, C Fitch, B Friedman, KJM Hanf, ...
Protein science 15 (5), 949-960, 2006
2152006
Stabilized polypeptide compositions
S Glaser, S Demarest, BR Miller, WB Snyder, X Wu, N Wang, LJ Croner, ...
US Patent 7,951,918, 2011
2082011
A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins
P Zhou, AA Lugovskoy, G Wagner
Journal of biomolecular NMR 20, 11-14, 2001
1972001
Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
G Farrington, A Lugovskoy, W Meier, J Eldredge, E Garber
US Patent App. 11/432,872, 2007
1942007
Single-chain Fc (scFc) regions, binding polypeptides comprising same, and methods related thereto
GK Farrington, A Saeed-Kothe, E Garber, AA Lugovskoy
US Patent App. 12/152,622, 2009
1812009
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
M Rushe, L Silvian, S Bixler, LL Chen, A Cheung, S Bowes, H Cuervo, ...
Structure 16 (5), 798-808, 2008
1762008
Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity
L Gorelik, C Reid, M Testa, M Brickelmaier, S Bossolasco, A Pazzi, ...
Journal of Infectious Diseases 204 (1), 103-114, 2011
1722011
Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-β
N Di Clemente, SP Jamin, A Lugovskoy, P Carmillo, C Ehrenfels, ...
Molecular endocrinology 24 (11), 2193-2206, 2010
1702010
Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
P Schneider, D Olson, A Tardivel, B Browning, A Lugovskoy, DH Gong, ...
Journal of Biological Chemistry 278 (7), 5444-5454, 2003
1662003
A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors
AA Lugovskoy, AI Degterev, AF Fahmy, P Zhou, JD Gross, J Yuan, ...
Journal of the American Chemical Society 124 (7), 1234-1240, 2002
1662002
Stability engineering of scFvs for the development of bispecific and multivalent antibodies
BR Miller, SJ Demarest, A Lugovskoy, F Huang, X Wu, WB Snyder, ...
Protein Engineering, Design & Selection 23 (7), 549-557, 2010
1622010
Small molecule inhibition of phosphatidylinositol-3, 4, 5-triphosphate (PIP3) binding to pleckstrin homology domains
B Miao, I Skidan, J Yang, A Lugovskoy, M Reibarkh, K Long, T Brazell, ...
Proceedings of the National Academy of Sciences 107 (46), 20126-20131, 2010
1612010
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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