James M. Murphy

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John SilkeProfessor, The Walter and Eliza Hall InstituteVerified email at latrobe.edu.au
Joanne (Hulett) HildebrandSenior Research Scientist, WEHIVerified email at wehi.edu.au
jeff babonwalter and eliza hall instituteVerified email at wehi.edu.au
Andrew I. WebbAssociate Professor - The Walter and Eliza Hall InstituteVerified email at wehi.edu.au
James E VinceThe Walter and Eliza Hall Institute of Medical ResearchVerified email at wehi.edu.au
Renwick CJ DobsonProfessor of Chemical Biology, School of Biological Sciences, University of CanterburyVerified email at canterbury.ac.nz
Jarrod SandowThe Walter and Eliza Hall InstituteVerified email at wehi.edu.au
Maria C TanzerMax-Planck of BiochemistryVerified email at biochem.mpg.de
Blewitt ME, Blewitt M, Champ MELaboratory head, Walter and Eliza Hall InstituteVerified email at wehi.edu.au
Kate E LawlorGroup Head, Cell Death and Inflammatory Signalling, Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Adjunct Research Fellow, Department of Molecular and Translational Science, Monash UniversityVerified email at hudson.org.au
Patrick A. EyersHead of Biochemistry, Cell & Systems Biology, University of Liverpool. CSO Sulantrix LtdVerified email at liverpool.ac.uk
Lachlan WhiteheadWalter and Eliza Hall Institute of Medical ResearchVerified email at wehi.edu.au
Peter D MaceProfessor, University of Otago, New ZealandVerified email at otago.ac.nz
Andreas StrasserThe Walter and Eliza Hall InstituteVerified email at wehi.edu.au
Jaclyn S PearsonPhD Hudson Institute of Medical ResearchVerified email at hudson.org.au
Kelly Lee ROGERSHead, Centre for Dynamic Imaging, Walter and Eliza Hall InstituteVerified email at wehi.edu.au
frank sicheriLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalVerified email at lunenfeld.ca
Wai-Hong ThamWalter and Eliza Hall InstituteVerified email at wehi.edu.au
Gerard ManningDirector of Bioinformatics, GenentechVerified email at gene.com

James M. Murphy

Head of Inflammation Division, Walter and Eliza Hall Institute of Medical Research

Verified email at wehi.edu.au - Homepage

kinases pseudokinases cell death necroptosis signal transduction


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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013	1138	2013
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis JA Rickard, JA O’Donnell, JM Evans, N Lalaoui, AR Poh, TW Rogers, ... Cell 157 (5), 1175-1188, 2014	589	2014
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014	556	2014
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Núñez, ... Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017	387	2017
The molecular regulation of Janus kinase (JAK) activation JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese Biochemical Journal 462 (1), 1-13, 2014	369	2014
The molecular basis of JAK/STAT inhibition by SOCS1 NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ... Nature communications 9 (1), 1558, 2018	362	2018
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ... Immunity 36 (2), 239-250, 2012	312	2012
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ... Nature structural & molecular biology 20 (4), 469-476, 2013	301	2013
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure T Müller, C Dewitz, J Schmitz, AS Schröder, JH Bräsen, BR Stockwell, ... Cellular and Molecular Life Sciences 74, 3631-3645, 2017	291	2017
MK2 phosphorylates RIPK1 to prevent TNF-induced cell death I Jaco, A Annibaldi, N Lalaoui, R Wilson, T Tenev, L Laurien, C Kim, ... Molecular cell 66 (5), 698-710. e5, 2017	272	2017
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ... Biochemical Journal 457 (2), 323-334, 2014	271	2014
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice JA Rickard, H Anderton, N Etemadi, U Nachbur, M Darding, N Peltzer, ... Elife 3, e03464, 2014	255	2014
Regulated necrosis in kidney ischemia-reperfusion injury A Pefanis, FL Ierino, JM Murphy, PJ Cowan Kidney international 96 (2), 291-301, 2019	227	2019
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020	217	2020
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax J Gruszczyk, U Kanjee, LJ Chan, S Menant, B Malleret, NTY Lim, ... Science 359 (6371), 48-55, 2018	193	2018
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ... Nature microbiology 2 (4), 1-10, 2017	176	2017
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018	173	2018
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1 DM Moujalled, WD Cook, T Okamoto, J Murphy, KE Lawlor, JE Vince, ... Cell death & disease 4 (1), e465-e465, 2013	173	2013
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner WWL Wong, JE Vince, N Lalaoui, KE Lawlor, D Chau, A Bankovacki, ... Blood, The Journal of the American Society of Hematology 123 (16), 2562-2572, 2014	171	2014
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016	154	2016

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