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Joseph Chemler
Joseph Chemler
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Zitiert von
Zitiert von
Jahr
Structure of a modular polyketide synthase
S Dutta, JR Whicher, DA Hansen, WA Hale, JA Chemler, GR Congdon, ...
Nature 510 (7506), 512-517, 2014
2842014
Metabolic engineering for plant natural product biosynthesis in microbes
JA Chemler, MAG Koffas
Current opinion in biotechnology 19 (6), 597-605, 2008
2072008
Improving NADPH availability for natural product biosynthesis in Escherichia coli by metabolic engineering
JA Chemler, ZL Fowler, KP McHugh, MAG Koffas
Metabolic engineering 12 (2), 96-104, 2010
2042010
Structural rearrangements of a polyketide synthase module during its catalytic cycle
JR Whicher, S Dutta, DA Hansen, WA Hale, JA Chemler, AM Dosey, ...
Nature 510 (7506), 560-564, 2014
1792014
Metabolic Engineering of Anthocyanin Biosynthesis in Escherichia coli
Y Yan, J Chemler, L Huang, S Martens, MAG Koffas
Applied and Environmental Microbiology 71 (7), 3617-3623, 2005
1632005
Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae
JA Chemler, Y Yan, MAG Koffas
Microbial Cell Factories 5 (1), 1-9, 2006
1482006
Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli
E Leonard, J Chemler, KH Lim, MAG Koffas
Applied microbiology and biotechnology 70 (1), 85-91, 2006
952006
Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion
JA Chemler, LT Lock, MAG Koffas, ES Tzanakakis
Applied Microbiology and Biotechnology 77 (4), 797-807, 2007
822007
Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms
JA Chemler, Y Yan, E Leonard, MAG Koffas
Organic letters 9 (10), 1855-1858, 2007
622007
Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor
JA Chemler, TJ Buchholz, TW Geders, DL Akey, CM Rath, GE Chlipala, ...
Journal of the American Chemical Society 134 (17), 7359-7366, 2012
582012
Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ...
ACS chemical biology 12 (1), 114-123, 2017
542017
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C H Functionalization
AN Lowell, MD DeMars, ST Slocum, F Yu, K Anand, JA Chemler, ...
Journal of the American Chemical Society 139 (23), 7913-7920, 2017
532017
Evolution of efficient modular polyketide synthases by homologous recombination
JA Chemler, A Tripathi, DA Hansen, M O’Neil-Johnson, RB Williams, ...
Journal of the American Chemical Society 137 (33), 10603-10609, 2015
362015
Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS
SA Bonnett, CM Rath, AR Shareef, JR Joels, JA Chemler, K Håkansson, ...
Chemistry & biology 18 (9), 1075-1081, 2011
342011
A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity
JA Chemler, CG Lim, JL Daiss, MAG Koffas
Chemistry & biology 17 (4), 392-401, 2010
302010
Characterization of dihydroflavonol 4-reductases for recombinant plant pigment biosynthesis applications
E Leonard, Y Yan, J Chemler, U Matern, S Martens, MAG Koffas
Biocatalysis and Biotransformation 26 (3), 243-251, 2008
242008
A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S] 2+ cluster
KJ McDonnell, JA Chemler, PL Bartels, E O’Brien, ML Marvin, J Ortega, ...
Nature chemistry 10 (8), 873-880, 2018
162018
Flavonoid biotransformations in microorganisms
JA Chemler, E Leonard, MAG Koffas
Anthocyanins, 191-255, 2008
122008
Natural product bis-intercalator depsipeptides as a new class of payloads for antibody–drug conjugates
AS Ratnayake, L Chang, LN Tumey, F Loganzo, JA Chemler, ...
Bioconjugate Chemistry 30 (1), 200-209, 2018
92018
Probing selectivity and creating structural diversity through hybrid polyketide synthases
AA Koch, JJ Schmidt, AN Lowell, DA Hansen, KM Coburn, JA Chemler, ...
Angewandte Chemie 132 (32), 13677-13682, 2020
52020
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