Sergio Altamura
Sergio Altamura
Head of Biology, IRBM Science Park
Verified email at
Cited by
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Elevated levels of interleukin-6 in unstable angina
LM Biasucci, A Vitelli, G Liuzzo, S Altamura, G Caligiuri, C Monaco, ...
Circulation 94 (5), 874-877, 1996
Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina
G Liuzzo, A Buffon, LM Biasucci, JR Gallimore, G Caligiuri, A Vitelli, ...
Circulation 98 (22), 2370-2376, 1998
Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro
G Migliaccio, JE Tomassini, SS Carroll, L Tomei, S Altamura, B Bhat, ...
Journal of Biological Chemistry 278 (49), 49164-49170, 2003
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
R De Francesco, L Tomei, S Altamura, V Summa, G Migliaccio
Antiviral research 58 (1), 1-16, 2003
Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in …
P Jones, S Altamura, J Boueres, F Ferrigno, M Fonsi, C Giomini, ...
Journal of medicinal chemistry 52 (22), 7170-7185, 2009
Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products
P Ingallinella, S Altamura, E Bianchi, M Taliani, R Ingenito, R Cortese, ...
Biochemistry 37 (25), 8906-8914, 1998
Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase
L Tomei, S Altamura, L Bartholomew, A Biroccio, A Ceccacci, L Pacini, ...
Journal of Virology 77 (24), 13225-13231, 2003
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site
S Di Marco, C Volpari, L Tomei, S Altamura, S Harper, F Narjes, U Koch, ...
Journal of Biological Chemistry 280 (33), 29765-29770, 2005
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture
P Neddermann, M Quintavalle, C Di Pietro, A Clementi, M Cerretani, ...
Journal of virology 78 (23), 13306-13314, 2004
Discovery of α, γ-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase
V Summa, A Petrocchi, P Pace, VG Matassa, R De Francesco, S Altamura, ...
Journal of medicinal chemistry 47 (1), 14-17, 2004
Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides
L Tomei, S Altamura, L Bartholomew, M Bisbocci, C Bailey, M Bosserman, ...
Journal of virology 78 (2), 938-946, 2004
Rational design of a receptor super‐antagonist of human interleukin‐6.
R Savino, L Ciapponi, A Lahm, A Demartis, A Cabibbo, C Toniatti, ...
The EMBO Journal 13 (24), 5863-5870, 1994
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease
F Narjes, KF Koehler, U Koch, B Gerlach, S Colarusso, C Steinkühler, ...
Bioorganic & medicinal chemistry letters 12 (4), 701-704, 2002
Generation of interleukin‐6 receptor antagonists by molecular‐modeling guided mutagenesis of residues important for gp130 activation.
R Savino, A Lahm, AL Salvati, L Ciapponi, E Sporeno, S Altamura, ...
The EMBO journal 13 (6), 1357-1367, 1994
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
C Trozzi, L Bartholomew, A Ceccacci, G Biasiol, L Pacini, S Altamura, ...
Journal of Virology 77 (6), 3669-3679, 2003
2-(2-Thienyl)-5, 6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis
U Koch, B Attenni, S Malancona, S Colarusso, I Conte, M Di Filippo, ...
Journal of medicinal chemistry 49 (5), 1693-1705, 2006
Affinity selection of a camelized V (H) domain antibody inhibitor of hepatitis C virus NS3 protease.
F Martin, C Volpari, C Steinkuhler, N Dimasi, M Brunetti, G Biasiol, ...
Protein Engineering 10 (5), 607-614, 1997
HCV NS5b RNA-dependent RNA polymerase inhibitors: from α, γ-diketoacids to 4, 5-dihydroxypyrimidine-or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis
V Summa, A Petrocchi, VG Matassa, M Taliani, R Laufer, R De Francesco, ...
Journal of medicinal chemistry 47 (22), 5336-5339, 2004
Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence
L Tomei, RL Vitale, I Incitti, S Serafini, S Altamura, A Vitelli, ...
Microbiology 81 (3), 759-767, 2000
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase
S Harper, S Avolio, B Pacini, M Di Filippo, S Altamura, L Tomei, ...
Journal of medicinal chemistry 48 (14), 4547-4557, 2005
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