Manfroni Giuseppe
Manfroni Giuseppe
Ricercatore Chimica farmaceutica, Università di Perugia
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Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of the S. aureus NorA Efflux Pump
S Sabatini, F Gosetto, G Manfroni, O Tabarrini, GW Kaatz, D Patel, ...
Journal of medicinal chemistry 54 (16), 5722-5736, 2011
Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents
O Tabarrini, G Manfroni, A Fravolini, V Cecchetti, S Sabatini, E De Clercq, ...
Journal of medicinal chemistry 49 (8), 2621-2627, 2006
Pyrazolo[4,3-c][1,2]benzothiazines 5,5-Dioxide: A Promising New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors
S Sabatini, F Gosetto, S Serritella, G Manfroni, O Tabarrini, N Iraci, ...
Journal of medicinal chemistry 55 (7), 3568-3572, 2012
Structure− activity relationship study on anti-HIV 6-desfluoroquinolones
O Tabarrini, S Massari, D Daelemans, M Stevens, G Manfroni, S Sabatini, ...
Journal of medicinal chemistry 51 (17), 5454-5458, 2008
Discovery of Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus
JP Brincat, E Carosati, S Sabatini, G Manfroni, A Fravolini, JL Raygada, ...
Journal of medicinal chemistry 54 (1), 354-365, 2011
A broad anti-influenza hybrid small molecule that potently disrupts the interaction of polymerase acidic protein–basic protein 1 (PA-PB1) subunits
S Massari, G Nannetti, J Desantis, G Muratore, S Sabatini, G Manfroni, ...
Journal of medicinal chemistry 58 (9), 3830-3842, 2015
Structure Modifications of 6-Aminoquinolones with Potent Anti-HIV Activity
O Tabarrini, M Stevens, V Cecchetti, S Sabatini, M Dell'Uomo, G Manfroni, ...
Journal of medicinal chemistry 47 (22), 5567-5578, 2004
Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity
P Blasi, A Schoubben, G Traina, G Manfroni, L Barberini, PF Alberti, ...
International journal of pharmaceutics 454 (1), 316-323, 2013
Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor
G Manfroni, J Paeshuyse, S Massari, S Zanoli, B Gatto, G Maga, ...
Journal of medicinal chemistry 52 (10), 3354-3365, 2009
Studies on anti-HIV quinolones: new insights on the C-6 position
S Massari, D Daelemans, G Manfroni, S Sabatini, O Tabarrini, ...
Bioorganic & medicinal chemistry 17 (2), 667-674, 2009
Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase
G Manfroni, F Meschini, ML Barreca, P Leyssen, A Samuele, N Iraci, ...
Bioorganic & medicinal chemistry 20 (2), 866-876, 2012
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to …
S Sabatini, F Gosetto, N Iraci, ML Barreca, S Massari, L Sancineto, ...
Journal of medicinal chemistry 56 (12), 4975-4989, 2013
Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor
D Tarantino, R Cannalire, E Mastrangelo, R Croci, G Querat, ML Barreca, ...
Antiviral research 134, 226-235, 2016
The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors
G Manfroni, R Cannalire, ML Barreca, N Kaushik-Basu, P Leyssen, ...
Journal of medicinal chemistry 57 (5), 1952-1963, 2014
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development
ML Barreca, N Iraci, G Manfroni, V Cecchetti
Future medicinal chemistry 3 (8), 1027-1055, 2011
Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors
A Astolfi, T Felicetti, N Iraci, G Manfroni, S Massari, D Pietrella, O Tabarrini, ...
Journal of medicinal chemistry 60 (4), 1598-1604, 2017
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication
ML Barreca, G Manfroni, P Leyssen, J Winquist, N Kaushik-Basu, ...
Journal of medicinal chemistry 56 (6), 2270-2282, 2013
Structural investigation of cycloheptathiophene-3-carboxamide derivatives targeting influenza virus polymerase assembly
S Massari, G Nannetti, L Goracci, L Sancineto, G Muratore, S Sabatini, ...
Journal of medicinal chemistry 56 (24), 10118-10131, 2013
Novel 1,4-Benzothiazine Derivatives as Large Conductance Ca2+-Activated Potassium Channel Openers
V Calderone, R Spogli, A Martelli, G Manfroni, L Testai, S Sabatini, ...
Journal of medicinal chemistry 51 (16), 5085-5092, 2008
A journey around the medicinal chemistry of hepatitis C virus inhibitors targeting NS4B: from target to preclinical drug candidates
R Cannalire, ML Barreca, G Manfroni, V Cecchetti
Journal of medicinal chemistry 59 (1), 16-41, 2016
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
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