|Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation|
P Jaakkola, DR Mole, YM Tian, MI Wilson, J Gielbert, SJ Gaskell, ...
Science 292 (5516), 468-472, 2001
|C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation|
ACR Epstein, JM Gleadle, LA McNeill, KS Hewitson, J O'Rourke, DR Mole, ...
Cell 107 (1), 43-54, 2001
|Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein|
ME Cockman, N Masson, DR Mole, P Jaakkola, GW Chang, SC Clifford, ...
Journal of Biological Chemistry 275 (33), 25733-25741, 2000
|HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability|
JS Isaacs, YJ Jung, DR Mole, S Lee, C Torres-Cabala, YL Chung, ...
Cancer cell 8 (2), 143-153, 2005
|High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq|
J Sch÷del, S Oikonomopoulos, J Ragoussis, CW Pugh, PJ Ratcliffe, ...
Blood, The Journal of the American Society of Hematology 117 (23), e207-e217, 2011
|Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts|
DR Mole, C Blancher, RR Copley, PJ Pollard, JM Gleadle, J Ragoussis, ...
Journal of biological chemistry 284 (25), 16767-16775, 2009
|Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia|
SO Ang, H Chen, K Hirota, VR Gordeuk, J Jelinek, Y Guan, E Liu, ...
Nature genetics 32 (4), 614-621, 2002
|Contrasting effects on HIF-1α regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease|
SC Clifford, ME Cockman, AC Smallwood, DR Mole, ER Woodward, ...
Human molecular genetics 10 (10), 1029-1038, 2001
|Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α|
PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ...
Biochemical Journal 416 (3), 387-394, 2008
|Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival|
H Choudhry, A Albukhari, M Morotti, S Haider, D Moralli, J Smythies, ...
Oncogene 34 (34), 4482-4490, 2015
|The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1|
R Schietke, C Warnecke, I Wacker, J Sch÷del, DR Mole, V Campean, ...
Journal of Biological Chemistry 285 (9), 6658-6669, 2010
|2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase|
DR Mole, I Schlemminger, LA McNeill, KS Hewitson, CW Pugh, ...
Bioorganic & medicinal chemistry letters 13 (16), 2677-2680, 2003
|Hypoxia, hypoxia-inducible transcription factors, and renal cancer|
J Sch÷del, S Grampp, ER Maher, H Moch, PJ Ratcliffe, P Russo, DR Mole
European urology 69 (4), 646-657, 2016
|Common genetic variants at the 11q13. 3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression|
J Sch÷del, C Bardella, LK Sciesielski, JM Brown, CW Pugh, V Buckle, ...
Nature genetics 44 (4), 420-425, 2012
|Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis|
S Lakhal, J Sch÷del, ARM Townsend, CW Pugh, PJ Ratcliffe, DR Mole
Journal of Biological Chemistry 286 (6), 4090-4097, 2011
|Determination and comparison of specific activity of the HIF-prolyl hydroxylases|
JR Tuckerman, Y Zhao, KS Hewitson, YM Tian, CW Pugh, PJ Ratcliffe, ...
FEBS letters 576 (1-2), 145-150, 2004
|Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1 α, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases|
HJ Knowles, YM Tian, DR Mole, AL Harris
Circulation research 95 (2), 162-169, 2004
|miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis|
RI McCormick, C Blick, J Ragoussis, J Schoedel, DR Mole, AC Young, ...
British journal of cancer 108 (5), 1133-1142, 2013
|Extensive regulation of the non‐coding transcriptome by hypoxia: role of HIF in releasing paused RNA pol2|
H Choudhry, J Sch÷del, S Oikonomopoulos, C Camps, S Grampp, ...
EMBO reports 15 (1), 70-76, 2014
|Regulation of HIF by the von Hippel‐Lindau tumour suppressor: implications for cellular oxygen sensing|
DR Mole, PH Maxwell, CW Pugh, PJ Ratcliffe
IUBMB life 52 (1), 43-47, 2001