Andrea Astolfi
Andrea Astolfi
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Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors
A Astolfi, T Felicetti, N Iraci, G Manfroni, S Massari, D Pietrella, O Tabarrini, ...
Journal of medicinal chemistry 60 (4), 1598-1604, 2017
Pharmacological inactivation of the prion protein by targeting a folding intermediate
G Spagnolli, T Massignan, A Astolfi, S Biggi, M Rigoli, P Brunelli, ...
Communications Biology 4 (1), 62, 2021
Functionalized 2, 1-benzothiazine 2, 2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase
R Cannalire, D Tarantino, A Astolfi, ML Barreca, S Sabatini, S Massari, ...
European journal of medicinal chemistry 143, 1667-1676, 2018
Pyridobenzothiazolones exert potent anti-dengue activity by hampering multiple functions of NS5 polymerase
R Cannalire, KW Ki Chan, MS Burali, CP Gwee, S Wang, A Astolfi, ...
ACS Medicinal Chemistry Letters 11 (5), 773-782, 2020
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity
J Desantis, S Massari, A Corona, A Astolfi, S Sabatini, G Manfroni, ...
Molecules 25 (5), 1183, 2020
A comprehensive structural overview of p38α mitogen‐activated protein kinase in complex with ATP‐site and non‐ATP‐site binders
A Astolfi, G Manfroni, V Cecchetti, ML Barreca
ChemMedChem 13 (1), 7-14, 2018
Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics …
D Palazzotti, M Bissaro, G Bolcato, A Astolfi, T Felicetti, S Sabatini, ...
International journal of molecular sciences 20 (16), 4041, 2019
p38α MAPK and type I inhibitors: binding site analysis and use of target ensembles in virtual screening
A Astolfi, N Iraci, S Sabatini, ML Barreca, V Cecchetti
Molecules 20 (9), 15842-15861, 2015
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation
A Astolfi, M Kudolo, J Brea, G Manni, G Manfroni, D Palazzotti, S Sabatini, ...
European Journal of Medicinal Chemistry 182, 111624, 2019
A comprehensive structural overview of p38α MAPK in complex with type I inhibitors
A Astolfi, N Iraci, G Manfroni, ML Barreca, V Cecchetti
ChemMedChem 10 (6), 957-969, 2015
The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen‐activated protein kinase inhibitors
S Sabatini, G Manfroni, ML Barreca, SM Bauer, M Gargaro, R Cannalire, ...
Chemical biology & drug design 86 (4), 531-545, 2015
Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface
S Biggi, M Pancher, C Stincardini, S Luotti, T Massignan, A Dalle Vedove, ...
Journal of Neurochemistry 152 (1), 136-150, 2020
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors
T Felicetti, G Mangiaterra, R Cannalire, N Cedraro, D Pietrella, A Astolfi, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 584-597, 2020
Modifications on C6 and C7 positions of 3-phenylquinolone efflux pump inhibitors led to potent and safe antimycobacterial treatment adjuvants
T Felicetti, D Machado, R Cannalire, A Astolfi, S Massari, O Tabarrini, ...
ACS Infectious Diseases 5 (6), 982-1000, 2019
The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases
A Astolfi, G Spagnolli, E Biasini, ML Barreca
ACS Medicinal Chemistry Letters 11 (11), 2063-2067, 2020
Small molecules targeting DNA polymerase theta (POLθ) as promising synthetic lethal agents for precision cancer therapy
MC Pismataro, A Astolfi, ML Barreca, M Pacetti, S Schenone, T Bandiera, ...
Journal of medicinal chemistry 66 (10), 6498-6522, 2023
From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search
N Cedraro, R Cannalire, A Astolfi, G Mangiaterra, T Felicetti, S Vaiasicca, ...
ChemMedChem 16 (19), 3044-3059, 2021
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors
R Cannalire, G Mangiaterra, T Felicetti, A Astolfi, N Cedraro, S Massari, ...
International Journal of Molecular Sciences 21 (19), 7037, 2020
Antimalarial artefenomel inhibits human SARS-CoV-2 replication in cells while suppressing the receptor ACE2
T Massignan, A Boldrini, L Terruzzi, G Spagnolli, A Astolfi, V Bonaldo, ...
arXiv preprint arXiv:2004.13493, 2020
Q-raKtion: a semiautomated KNIME workflow for bioactivity data points curation
D Palazzotti, M Fiorelli, S Sabatini, S Massari, ML Barreca, A Astolfi
Journal of Chemical Information and Modeling 62 (24), 6309-6315, 2022
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