| Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors A Astolfi, T Felicetti, N Iraci, G Manfroni, S Massari, D Pietrella, O Tabarrini, ... Journal of medicinal chemistry 60 (4), 1598-1604, 2017 | 71 | 2017 |
| Pharmacological inactivation of the prion protein by targeting a folding intermediate G Spagnolli, T Massignan, A Astolfi, S Biggi, M Rigoli, P Brunelli, ... Communications Biology 4 (1), 62, 2021 | 46 | 2021 |
| Pyridobenzothiazolones exert potent anti-dengue activity by hampering multiple functions of NS5 polymerase R Cannalire, KW Ki Chan, MS Burali, CP Gwee, S Wang, A Astolfi, ... ACS Medicinal Chemistry Letters 11 (5), 773-782, 2020 | 31 | 2020 |
| Functionalized 2, 1-benzothiazine 2, 2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase R Cannalire, D Tarantino, A Astolfi, ML Barreca, S Sabatini, S Massari, ... European journal of medicinal chemistry 143, 1667-1676, 2018 | 31 | 2018 |
| 1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity J Desantis, S Massari, A Corona, A Astolfi, S Sabatini, G Manfroni, ... Molecules 25 (5), 1183, 2020 | 27 | 2020 |
| A comprehensive structural overview of p38α mitogen‐activated protein kinase in complex with ATP‐site and non‐ATP‐site binders A Astolfi, G Manfroni, V Cecchetti, ML Barreca ChemMedChem 13 (1), 7-14, 2018 | 24 | 2018 |
| p38α MAPK and type I inhibitors: binding site analysis and use of target ensembles in virtual screening A Astolfi, N Iraci, S Sabatini, ML Barreca, V Cecchetti Molecules 20 (9), 15842-15861, 2015 | 24 | 2015 |
| Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics … D Palazzotti, M Bissaro, G Bolcato, A Astolfi, T Felicetti, S Sabatini, ... International journal of molecular sciences 20 (16), 4041, 2019 | 23 | 2019 |
| Small molecules targeting DNA polymerase theta (POLθ) as promising synthetic lethal agents for precision cancer therapy MC Pismataro, A Astolfi, ML Barreca, M Pacetti, S Schenone, T Bandiera, ... Journal of medicinal chemistry 66 (10), 6498-6522, 2023 | 22 | 2023 |
| Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation A Astolfi, M Kudolo, J Brea, G Manni, G Manfroni, D Palazzotti, S Sabatini, ... European Journal of Medicinal Chemistry 182, 111624, 2019 | 21 | 2019 |
| A comprehensive structural overview of p38α MAPK in complex with type I inhibitors A Astolfi, N Iraci, G Manfroni, ML Barreca, V Cecchetti ChemMedChem 10 (6), 957-969, 2015 | 21 | 2015 |
| Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface S Biggi, M Pancher, C Stincardini, S Luotti, T Massignan, A Dalle Vedove, ... Journal of Neurochemistry 152 (1), 136-150, 2020 | 18 | 2020 |
| The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen‐activated protein kinase inhibitors S Sabatini, G Manfroni, ML Barreca, SM Bauer, M Gargaro, R Cannalire, ... Chemical biology & drug design 86 (4), 531-545, 2015 | 16 | 2015 |
| C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors T Felicetti, G Mangiaterra, R Cannalire, N Cedraro, D Pietrella, A Astolfi, ... Journal of Enzyme Inhibition and Medicinal Chemistry 35 (1), 584-597, 2020 | 15 | 2020 |
| Modifications on C6 and C7 positions of 3-phenylquinolone efflux pump inhibitors led to potent and safe antimycobacterial treatment adjuvants T Felicetti, D Machado, R Cannalire, A Astolfi, S Massari, O Tabarrini, ... ACS Infectious Diseases 5 (6), 982-1000, 2019 | 14 | 2019 |
| The Compelling Demand for an Effective PrPC-Directed Therapy against Prion Diseases A Astolfi, G Spagnolli, E Biasini, ML Barreca ACS Medicinal Chemistry Letters 11 (11), 2063-2067, 2020 | 12 | 2020 |
| From Quinoline to Quinazoline‐Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search N Cedraro, R Cannalire, A Astolfi, G Mangiaterra, T Felicetti, S Vaiasicca, ... ChemMedChem 16 (19), 3044-3059, 2021 | 10 | 2021 |
| Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors R Cannalire, G Mangiaterra, T Felicetti, A Astolfi, N Cedraro, S Massari, ... International Journal of Molecular Sciences 21 (19), 7037, 2020 | 9 | 2020 |
| Q-raKtion: a semiautomated KNIME workflow for bioactivity data points curation D Palazzotti, M Fiorelli, S Sabatini, S Massari, ML Barreca, A Astolfi Journal of Chemical Information and Modeling 62 (24), 6309-6315, 2022 | 8 | 2022 |
| Antimalarial artefenomel inhibits human SARS-CoV-2 replication in cells while suppressing the receptor ACE2 T Massignan, A Boldrini, L Terruzzi, G Spagnolli, A Astolfi, V Bonaldo, ... arXiv preprint arXiv:2004.13493, 2020 | 7 | 2020 |
