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Ikuo Miyahisa
Ikuo Miyahisa
Takeda Pharmaceutical Co.
Verified email at takeda.com
Title
Cited by
Cited by
Year
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli
Y Katsuyama, N Funa, I Miyahisa, S Horinouchi
Chemistry & biology 14 (6), 613-621, 2007
2632007
Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster
I Miyahisa, M Kaneko, N Funa, H Kawasaki, H Kojima, Y Ohnishi, ...
Applied microbiology and biotechnology 68, 498-504, 2005
2232005
Combinatorial biosynthesis of flavones and flavonols in Escherichia coli
I Miyahisa, N Funa, Y Ohnishi, S Martens, T Moriguchi, S Horinouchi
Applied microbiology and biotechnology 71, 53-58, 2006
1872006
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
Y Tanaka, K Aikawa, G Nishida, M Homma, S Sogabe, S Igaki, Y Hayano, ...
Journal of medicinal chemistry 56 (23), 9635-9645, 2013
1222013
One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells
Y Katsuyama, I Miyahisa, N Funa, S Horinouchi
Applied microbiology and biotechnology 73, 1143-1149, 2007
842007
A Single Target Is Sufficient To Account for the Biological Effects of the A-Factor Receptor Protein of Streptomyces griseus
J Kato, I Miyahisa, M Mashiko, Y Ohnishi, S Horinouchi
Journal of bacteriology 186 (7), 2206-2211, 2004
552004
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact /KI) by Means of an Endpoint Competition Assay
Ikuo Miyahisa, Tomoya Sameshima, Mark S Hixon
Angewandte Chemie International Edition 54 (47), 14099–14102, 2015
46*2015
A novel selective inhibitor of delta-5 desaturase lowers insulin resistance and reduces body weight in diet-induced obese C57BL/6J mice
H Yashiro, S Takagahara, YO Tamura, I Miyahisa, J Matsui, H Suzuki, ...
PLoS One 11 (11), e0166198, 2016
382016
Discovery of novel and potent stearoyl coenzyme a desaturase 1 (SCD1) inhibitors as anticancer agents
K Imamura, N Tomita, Y Kawakita, Y Ito, K Ono, N Nii, T Miyazaki, ...
Bioorganic & medicinal chemistry 25 (14), 3768-3779, 2017
362017
Discovery of an irreversible and cell-active BCL6 inhibitor selectively targeting Cys53 located at the protein–protein interaction interface
T Sameshima, T Yamamoto, O Sano, S Sogabe, S Igaki, K Sakamoto, ...
Biochemistry 57 (8), 1369-1379, 2018
232018
Discovery of 3, 5-diphenyl-4-methyl-1, 3-oxazolidin-2-ones as novel, potent, and orally available Δ-5 desaturase (D5D) inhibitors
J Fujimoto, R Okamoto, N Noguchi, R Hara, S Masada, T Kawamoto, ...
Journal of Medicinal Chemistry 60 (21), 8963-8981, 2017
212017
In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor
S Nishizawa, H Sumi, Y Satoh, Y Yamamoto, S Kitazawa, K Honda, ...
European journal of pharmacology 807, 21-31, 2017
202017
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application
Y Hirozane, M Toyofuku, T Yogo, Y Tanaka, T Sameshima, I Miyahisa, ...
Bioorganic & Medicinal Chemistry Letters 29 (21), 126641, 2019
152019
T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time
I Miyahisa, H Suzuki, A Mizukami, Y Tanaka, M Ono, MS Hixon, J Matsui
ACS Medicinal Chemistry Letters 7 (9), 868-872, 2016
152016
Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792
M Sasaki, I Miyahisa, S Itono, H Yashiro, H Hiyoshi, K Tsuchimori, ...
Pharmacology research & perspectives 7 (5), e00517, 2019
122019
Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity
T Sameshima, T Yukawa, Y Hirozane, M Yoshikawa, T Katoh, H Hara, ...
Chemical Research in Toxicology 33 (1), 154-161, 2019
122019
High-throughput quantitative intrinsic thiol reactivity evaluation using a fluorescence-based competitive endpoint assay
T Sameshima, I Miyahisa, S Yamasaki, M Gotou, T Kobayashi, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 22 (9), 1168-1174, 2017
102017
Universal and quantitative method to evaluate inhibitor potency for cysteinome proteins using a nonspecific activity-based protein profiling probe
T Sameshima, Y Tanaka, I Miyahisa
Biochemistry 56 (23), 2921-2927, 2017
32017
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay
T Sameshima, I Miyahisa, M Homma, K Aikawa, MS Hixon, J Matsui
Bioorganic & Medicinal Chemistry Letters, 2014
22014
Asymmetric and Regiospecific Synthesis of Isotopically Labelled Cyclopropane Fatty Acid (9R, 10S)-Dihydrosterculic Acid: Overcoming Spontaneous Protonation During Lithium …
SWJ Shields, PH Buist, JM Manthorpe
SynOpen 2 (02), 0168-0175, 2018
12018
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