| OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome R Xu, AT Brawner, S Li, JJ Liu, H Kim, H Xue, ZP Pang, WY Kim, RP Hart, ... Cell stem cell 24 (6), 908-926. e8, 2019 | 137 | 2019 |
| Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain R Xu, X Li, AJ Boreland, A Posyton, K Kwan, RP Hart, P Jiang Nature communications 11 (1), 1577, 2020 | 130 | 2020 |
| Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology R Xu, AJ Boreland, X Li, C Erickson, M Jin, C Atkins, ZP Pang, BP Daniels, ... Stem cell reports 16 (8), 1923-1937, 2021 | 129 | 2021 |
| Pluripotent stem cell-derived cerebral organoids reveal human oligodendrogenesis with dorsal and ventral origins H Kim, R Xu, R Padmashri, A Dunaevsky, Y Liu, CF Dreyfus, P Jiang Stem cell reports 12 (5), 890-905, 2019 | 112 | 2019 |
| Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation S Wu, R Xu, B Duan, P Jiang Journal of materials chemistry B 5 (21), 3870-3878, 2017 | 106 | 2017 |
| Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease M Jin, R Xu, L Wang, MM Alam, Z Ma, S Zhu, AC Martini, A Jadali, ... Cell Stem Cell 29 (7), 1135-1153. e8, 2022 | 54 | 2022 |
| The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway R Xu, Q Hu, Q Ma, C Liu, G Wang Cell Death & Disease 5 (8), e1373-e1373, 2014 | 54 | 2014 |
| Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro L Zhou, H Wang, H Ren, D Chen, F Gao, Q Hu, C Fu, R Xu, Z Ying, ... Acta Pharmacologica Sinica 34 (5), 651-656, 2013 | 53 | 2013 |
| Generating CNS organoids from human induced pluripotent stem cells for modeling neurological disorders AT Brawner, R Xu, D Liu, P Jiang International Journal of Physiology, Pathophysiology and Pharmacology 9 (3), 101, 2017 | 35 | 2017 |
| Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence B Li, Q Hu, R Xu, H Ren, E Fei, D Chen, G Wang BMC cell biology 13, 1-10, 2012 | 31 | 2012 |
| The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation Q Hu, B Li, R Xu, D Chen, C Mu, E Fei, G Wang Science signaling 5 (238), ra61-ra61, 2012 | 29 | 2012 |
| Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1 Q Ma, Q Hu, R Xu, X Zhen, G Wang Acta Pharmacologica Sinica 36 (8), 966-975, 2015 | 17 | 2015 |
| Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism L Wang, VR Mirabella, R Dai, X Su, R Xu, A Jadali, M Bernabucci, I Singh, ... Molecular psychiatry, 1-16, 2022 | 15 | 2022 |
| High-fidelity modeling of human microglia with pluripotent stem cells P Jiang, L Turkalj, R Xu Cell Stem Cell 26 (5), 629-631, 2020 | 13 | 2020 |
| Reversing abnormal neural development by inhibiting OLIG2 in down syndrome human iPSC brain organoids and neuronal mouse chimeras R Xu, AT Brawner, S Li, H Kim, H Xue, ZP Pang, WY Kim, RP Hart, Y Liu, ... BioRxiv, 462739, 2018 | 5 | 2018 |
| Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids J Wu, J Zhang, X Chen, K Wettschurack, Z Que, BA Deming, ... Molecular Psychiatry, 1-14, 2024 | 2 | 2024 |
| Functional Mature Human Microglia Developed in Human iPSC Microglial Chimeric Mouse Brain R Xu, AJ Boreland, X Li, A Posyton, K Kwan, RP Hart, P Jiang bioRxiv, 594721, 2019 | 1 | 2019 |
| Xenotransplantation of Human PSC-derived Microglia Creates a Chimeric Mouse Brain Model 2 that Recapitulates Features of Adult Human Microglia R Xu, A Boreland, A Posyton, K Kwan, RP Hart, P Jiang, P Jiang | 1 | 2019 |
| Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders Y Ji, JL McLean, R Xu Neuroscience Bulletin, 1-18, 2024 | | 2024 |
| Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation Z Que, MI Olivero-Acosta, I Chen, J Zhang, K Wettschurack, J Wu, T Xiao, ... bioRxiv, 2023 | | 2023 |
