| Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications J Sharifi-Rad, YE Rayess, AA Rizk, C Sadaka, R Zgheib, W Zam, S Sestito, ... Frontiers in pharmacology 11, 01021, 2020 | 532 | 2020 |
| Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo A Martelli, L Testai, V Citi, A Marino, I Pugliesi, E Barresi, G Nesi, ... ACS medicinal chemistry letters 4 (10), 904-908, 2013 | 176 | 2013 |
| Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment J Sharifi-Rad, C Quispe, M Butnariu, LS Rotariu, O Sytar, S Sestito, ... Cancer Cell International 21 (1), 318, 2021 | 173 | 2021 |
| Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole A Rossello, S Bertini, A Lapucci, M Macchia, A Martinelli, S Rapposelli, ... Journal of Medicinal Chemistry 45 (22), 4903-4912, 2002 | 172 | 2002 |
| Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease X Chao, X He, Y Yang, X Zhou, M Jin, S Liu, Z Cheng, P Liu, Y Wang, J Yu, ... Bioorganic & medicinal chemistry letters 22 (20), 6498-6502, 2012 | 120 | 2012 |
| Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells S Daniele, B Costa, E Zappelli, E Da Pozzo, S Sestito, G Nesi, ... Scientific reports 5 (1), 9956, 2015 | 104 | 2015 |
| Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity D Zhu, M Chen, M Li, B Luo, Y Zhao, P Huang, F Xue, S Rapposelli, R Pi, ... European journal of medicinal chemistry 68, 81-88, 2013 | 103 | 2013 |
| New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2) A Rossello, E Nuti, E Orlandini, P Carelli, S Rapposelli, M Macchia, ... Bioorganic & medicinal chemistry 12 (9), 2441-2450, 2004 | 101 | 2004 |
| Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells F Minutolo, G Sala, A Bagnacani, S Bertini, I Carboni, G Placanica, ... Journal of medicinal chemistry 48 (22), 6783-6786, 2005 | 99 | 2005 |
| Oxidative stress, mitochondrial abnormalities and proteins deposition: multitarget approaches in Alzheimer's disease G Nesi, S Sestito, M Digiacomo, S Rapposelli Current topics in medicinal chemistry 17 (27), 3062-3079, 2017 | 96 | 2017 |
| Mitochondrial potassium channels as pharmacological target for cardioprotective drugs L Testai, S Rapposelli, A Martelli, MC Breschi, V Calderone Medicinal Research Reviews 35 (3), 520-553, 2015 | 93 | 2015 |
| Proposal of a new binding orientation for non-peptide AT1 antagonists: Homology modeling, docking and three-dimensional quantitative structure− activity relationship analysis T Tuccinardi, V Calderone, S Rapposelli, A Martinelli Journal of medicinal chemistry 49 (14), 4305-4316, 2006 | 89 | 2006 |
| A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer’s disease X Zhang, X He, Q Chen, J Lu, S Rapposelli, R Pi Bioorganic & medicinal chemistry 26 (3), 543-550, 2018 | 82 | 2018 |
| Neffe-Skoci nska, K J Sharifi-Rad, YE Rayess, AA Rizk, C Sadaka, R Zgheib, W Zam, S Sestito, ... Zieli nska, D, 1-23, 2020 | 81 | 2020 |
| New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties MC Breschi, V Calderone, M Digiacomo, M Macchia, A Martelli, ... Journal of medicinal chemistry 49 (8), 2628-2639, 2006 | 77 | 2006 |
| Selective thyroid hormone receptor-beta (TRβ) agonists: New perspectives for the treatment of metabolic and neurodegenerative disorders F Saponaro, S Sestito, M Runfola, S Rapposelli, G Chiellini Frontiers in Medicine 7, 331, 2020 | 75 | 2020 |
| Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD M Digiacomo, Z Chen, S Wang, A Lapucci, M Macchia, X Yang, J Chu, ... Bioorganic & medicinal chemistry letters 25 (4), 807-810, 2015 | 72 | 2015 |
| Epibatidine: a promising natural alkaloid in health B Salehi, S Sestito, S Rapposelli, G Peron, D Calina, M Sharifi-Rad, ... Biomolecules 9 (1), 6, 2018 | 71 | 2018 |
| Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease Z Chen, M Digiacomo, Y Tu, Q Gu, S Wang, X Yang, J Chu, Q Chen, ... European Journal of Medicinal Chemistry 125, 784-792, 2017 | 69 | 2017 |
| NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs MC Breschi, V Calderone, M Digiacomo, A Martelli, E Martinotti, ... Journal of medicinal chemistry 47 (23), 5597-5600, 2004 | 66 | 2004 |
