| Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding SG Aller, J Yu, A Ward, Y Weng, S Chittaboina, R Zhuo, PM Harrell, ... Science 323 (5922), 1718-1722, 2009 | 2356 | 2009 |
| The catalytic cycle of P-glycoprotein AE Senior, MK Al-Shawi, IL Urbatsch FEBS letters 377 (3), 285-289, 1995 | 630 | 1995 |
| P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site (∗) IL Urbatsch, B Sankaran, J Weber, AE Senior Journal of Biological Chemistry 270 (33), 19383-19390, 1995 | 476 | 1995 |
| Both P-glycoprotein nucleotide-binding sites are catalytically active IL Urbatsch, B Sankaran, S Bhagat, AE Senior Journal of Biological Chemistry 270 (45), 26956-26961, 1995 | 300 | 1995 |
| Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain AB Ward, P Szewczyk, V Grimard, CW Lee, L Martinez, R Doshi, A Caya, ... Proceedings of the National Academy of Sciences 110 (33), 13386-13391, 2013 | 288 | 2013 |
| Crystal structure of the human sterol transporter ABCG5/ABCG8 JY Lee, LN Kinch, DM Borek, J Wang, J Wang, IL Urbatsch, XS Xie, ... Nature 533 (7604), 561-564, 2016 | 280 | 2016 |
| Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein IL Urbatsch, MK Al-Shawi, AE Senior Biochemistry 33 (23), 7069-7076, 1994 | 280 | 1994 |
| Bradford assay for determining protein concentration CL Kielkopf, W Bauer, IL Urbatsch Cold Spring Harbor Protocols 2020 (4), pdb. prot102269, 2020 | 259 | 2020 |
| Covalent inhibitors of P-glycoprotein ATPase activity. MK Al-Shawi, IL Urbatsch, AE Senior Journal of Biological Chemistry 269 (12), 8986-8992, 1994 | 190 | 1994 |
| Large scale purification of detergent-soluble p-glycoprotein frompichia pastoris cells and characterization of nucleotide binding properties of wild-type, walker a, and walker … N Lerner-Marmarosh, K Gimi, IL Urbatsch, P Gros, AE Senior Journal of Biological Chemistry 274 (49), 34711-34718, 1999 | 189 | 1999 |
| Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein P Szewczyk, H Tao, AP McGrath, M Villaluz, SD Rees, SC Lee, R Doshi, ... Acta Crystallographica Section D: Biological Crystallography 71 (3), 732-741, 2015 | 180 | 2015 |
| Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites IL Urbatsch, L Beaudet, I Carrier, P Gros Biochemistry 37 (13), 4592-4602, 1998 | 169 | 1998 |
| Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 DAP Gutmann, A Ward, IL Urbatsch, G Chang, HW van Veen Trends in biochemical sciences 35 (1), 36-42, 2010 | 168 | 2010 |
| Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein IL Urbatsch, AE Senior Archives of biochemistry and biophysics 316 (1), 135-140, 1995 | 151 | 1995 |
| Projection structure of P-glycoprotein by electron microscopy: evidence for a closed conformation of the nucleotide binding domains JY Lee, IL Urbatsch, AE Senior, S Wilkens Journal of Biological Chemistry 277 (42), 40125-40131, 2002 | 133 | 2002 |
| A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris J Bai, DJ Swartz, II Protasevich, CG Brouillette, PM Harrell, E Hildebrandt, ... PloS one 6 (8), e22577, 2011 | 131 | 2011 |
| Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly G Tombline, LA Bartholomew, IL Urbatsch, AE Senior Journal of Biological Chemistry 279 (30), 31212-31220, 2004 | 120 | 2004 |
| Distinct conformational spectrum of homologous multidrug ABC transporters A Moeller, SC Lee, H Tao, JA Speir, G Chang, IL Urbatsch, CS Potter, ... Structure 23 (3), 450-460, 2015 | 116 | 2015 |
| P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state IL Urbatsch, GA Tyndall, G Tombline, AE Senior Journal of Biological Chemistry 278 (25), 23171-23179, 2003 | 115 | 2003 |
| Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains Z Yang, C Wang, Q Zhou, J An, E Hildebrandt, LA Aleksandrov, ... Protein Science 23 (6), 769-789, 2014 | 107 | 2014 |
Clara L. KielkopfUniversity of RochesterVerified email at urmc.rochester.edu
