| Phenome-wide association studies across large population cohorts support drug target validation D Diogo, C Tian, CS Franklin, M Alanne-Kinnunen, M March, ... Nature communications 9 (1), 1-13, 2018 | 144 | 2018 |
| CANDID: a flexible method for prioritizing candidate genes for complex human traits JE Hutz, AT Kraja, HL McLeod, MA Province Genetic Epidemiology: The Official Publication of the International Genetic …, 2008 | 106 | 2008 |
| Urogenital and caudal dysgenesis in adrenocortical dysplasia ( acd ) mice is caused by a splicing mutation in a novel telomeric regulator CE Keegan, JE Hutz, T Else, M Adamska, SP Shah, AE Kent, JM Howes, ... Human molecular genetics 14 (1), 113-123, 2005 | 73 | 2005 |
| E7766, a macrocycle‐bridged stimulator of interferon genes (STING) agonist with potent pan‐genotypic activity DS Kim, A Endo, FG Fang, KC Huang, X Bao, H Choi, U Majumder, ... ChemMedChem 16 (11), 1741-1744, 2021 | 69 | 2021 |
| SF-1, DAX-1, and acd: molecular determinants of adrenocortical growth and steroidogenesis F Beuschlein, CE Keegan, DL Bavers, C Mutch, JE Hutz, S Shah, ... Endocrine research 28 (4), 597-607, 2002 | 52 | 2002 |
| Tpp1/Acd maintains genomic stability through a complex role in telomere protection T Else, BK Theisen, Y Wu, JE Hutz, CE Keegan, GD Hammer, ... Chromosome research 15, 1001-1013, 2007 | 42 | 2007 |
| The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens JE Hutz, T Nelson, H Wu, G McAllister, I Moutsatsos, SA Jaeger, ... Journal of biomolecular screening 18 (4), 367-377, 2013 | 37 | 2013 |
| Causal network models for predicting compound targets and driving pathways in cancer S Jaeger, J Min, F Nigsch, M Camargo, J Hutz, A Cornett, S Cleaver, ... Journal of biomolecular screening 19 (5), 791-802, 2014 | 31 | 2014 |
| IMAGe association and congenital adrenal hypoplasia: No disease-causing mutations found in the ACD gene JE Hutz, AS Krause, JC Achermann, E Vilain, M Tauber, C Lecointre, ... Molecular genetics and metabolism 88 (1), 66-70, 2006 | 22 | 2006 |
| Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins JE Hutz, WA Manning, MA Province, HL McLeod PloS one 6 (9), e24873, 2011 | 15 | 2011 |
| Determination of minimal transcriptional signatures of compounds for target prediction F Nigsch, J Hutz, B Cornett, DW Selinger, G McAllister, S Bandyopadhyay, ... EURASIP Journal on Bioinformatics and Systems Biology 2012, 1-10, 2012 | 13 | 2012 |
| Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity A Endo, DS Kim, KC Huang, MH Hao, S Mathieu, H Choi, U Majumder, ... Cancer Research 79 (13_Supplement), 4456-4456, 2019 | 12 | 2019 |
| Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer KC Huang, D Chandra, S McGrath, V Dixit, C Zhang, J Wu, K Tendyke, ... Molecular Cancer Therapeutics 21 (6), 914-924, 2022 | 11 | 2022 |
| Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumoral … KC Huang, A Endo, S McGrath, D Chandra, J Wu, DS Kim, D Albu, ... Cancer Research 79 (13_Supplement), 3269-3269, 2019 | 8 | 2019 |
| Novel polymorphisms and lack of mutations in the ACD gene in patients with ACTH resistance syndromes CE Keegan, JE Hutz, AS Krause, K Koehler, LA Metherell, S Boikos, ... Clinical endocrinology 67 (2), 168-174, 2007 | 8 | 2007 |
| Demonstration of E7766, a novel STING agonist, as a potent immunotherapy in BCG-insensitive non-muscle invasive bladder cancer models via intravesical administration KC Huang, C Zhang, K Yu, DS Kim, V Dixit, R Hukkanen, HW Choi, J Hutz, ... Cancer Research 80 (16_Supplement), 592-592, 2020 | 7 | 2020 |
| Abstract 4456: Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity A Endo, DS Kim, KC Huang, MH Hao, S Mathieu, HW Choi, U Majumder, ... Am. Assoc. Cancer Res 79, 4456, 2019 | 7 | 2019 |
| Genetic analysis of the PI3K/AKT/mTOR signaling pathway JE Hutz WASHINGTON UNIVERSITY IN ST. LOUIS, 2010 | 3 | 2010 |
| Target Gene Notebook: Connecting genetics and drug discovery MP Reeve, A Kirby, J Wierzbowski, M Daly, J Hutz bioRxiv, 757690, 2019 | 1 | 2019 |
| Correction: Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer KC Huang, D Chandra, S McGrath, V Dixit, C Zhang, J Wu, K Tendyke, ... Molecular Cancer Therapeutics 22 (4), 551-551, 2023 | | 2023 |
