| Constructing biocatalytic cascades: in vitro and in vivo approaches to de novo multi-enzyme pathways SP France, LJ Hepworth, NJ Turner, SL Flitsch Acs Catalysis 7 (1), 710-724, 2017 | 371 | 2017 |
| Biocatalysis EL Bell, W Finnigan, SP France, AP Green, MA Hayes, LJ Hepworth, ... Nature Reviews Methods Primers 1 (1), 1-21, 2021 | 354 | 2021 |
| A reductive aminase from Aspergillus oryzae GA Aleku, SP France, H Man, J Mangas-Sanchez, SL Montgomery, ... Nature chemistry 9 (10), 961-969, 2017 | 334 | 2017 |
| Imine reductases (IREDs) J Mangas-Sanchez, SP France, SL Montgomery, GA Aleku, H Man, ... Current opinion in chemical biology 37, 19-25, 2017 | 232 | 2017 |
| One-pot cascade synthesis of mono-and disubstituted piperidines and pyrrolidines using carboxylic acid reductase (CAR), ω-transaminase (ω-TA), and imine reductase (IRED … SP France, S Hussain, AM Hill, LJ Hepworth, RM Howard, KR Mulholland, ... Acs Catalysis 6 (6), 3753-3759, 2016 | 211 | 2016 |
| An (R)‐Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines S Hussain, F Leipold, H Man, E Wells, SP France, KR Mulholland, ... ChemCatChem 7 (4), 579-583, 2015 | 171 | 2015 |
| Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis GA Aleku, H Man, SP France, F Leipold, S Hussain, L Toca-Gonzalez, ... Acs Catalysis 6 (6), 3880-3889, 2016 | 121 | 2016 |
| Identification of novel bacterial members of the imine reductase enzyme family that perform reductive amination SP France, RM Howard, J Steflik, NJ Weise, J Mangas‐Sanchez, ... ChemCatChem 10 (3), 510-514, 2018 | 99 | 2018 |
| Enzyme cascades in whole cells for the synthesis of chiral cyclic amines LJ Hepworth, SP France, S Hussain, P Both, NJ Turner, SL Flitsch ACS Catalysis 7 (4), 2920-2925, 2017 | 98 | 2017 |
| A mechanism for reductive amination catalyzed by fungal reductive aminases M Sharma, J Mangas-Sanchez, SP France, GA Aleku, SL Montgomery, ... ACS Catalysis 8 (12), 11534-11541, 2018 | 89 | 2018 |
| Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines SP France, GA Aleku, M Sharma, J Mangas‐Sanchez, RM Howard, ... Angewandte Chemie International Edition 56 (49), 15589-15593, 2017 | 76 | 2017 |
| Kinetic resolution and deracemization of racemic amines using a reductive aminase GA Aleku, J Mangas‐Sanchez, J Citoler, SP France, SL Montgomery, ... ChemCatChem 10 (3), 515-519, 2018 | 56 | 2018 |
| One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles TW Thorpe, SP France, S Hussain, JR Marshall, W Zawodny, ... Journal of the American Chemical Society 141 (49), 19208-19213, 2019 | 53 | 2019 |
| Carboxylic acid reductases (CARs): An industrial perspective SR Derrington, NJ Turner, SP France Journal of biotechnology 304, 78-88, 2019 | 50 | 2019 |
| Imine reductases, reductive aminases, and amine oxidases for the synthesis of chiral amines: discovery, characterization, and synthetic applications SC Cosgrove, A Brzezniak, SP France, JI Ramsden, J Mangas-Sanchez, ... Methods in enzymology 608, 131-149, 2018 | 42 | 2018 |
| Synthesis of 2,5‐Disubstituted Pyrrolidine Alkaloids via A One‐Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts BZ Costa, JL Galman, I Slabu, SP France, AJ Marsaioli, NJ Turner ChemCatChem 10 (20), 4733-4738, 2018 | 38 | 2018 |
| The evolving nature of biocatalysis in pharmaceutical research and development SP France, RD Lewis, CA Martinez JACS Au 3 (3), 715-735, 2023 | 33 | 2023 |
| Synthetic approaches to the new drugs approved during 2019 AC Flick, CA Leverett, HX Ding, E McInturff, SJ Fink, S Mahapatra, ... Journal of Medicinal Chemistry 64 (7), 3604-3657, 2021 | 33 | 2021 |
| PF-07059013: a noncovalent modulator of hemoglobin for treatment of sickle cell disease A Gopalsamy, AE Aulabaugh, A Barakat, KC Beaumont, S Cabral, ... Journal of Medicinal Chemistry 64 (1), 326-342, 2020 | 32 | 2020 |
| Inducing achiral aliphatic oligoureas to fold into helical conformations R Wechsel, J Maury, J Fremaux, SP France, G Guichard, J Clayden Chemical communications 50 (95), 15006-15009, 2014 | 25 | 2014 |
