| Echinomycin: a bifunctional intercalating antibiotic MJ Waring, LPG Wakelin Nature 252 (5485), 653-657, 1974 | 369 | 1974 |
| Polyfunctional DNA intercalating agents LPG Wakelin Medicinal research reviews 6 (3), 275-340, 1986 | 283 | 1986 |
| Binding of echinomycin to DNA LPG Wakelin, MJ Waring Biochemical Journal 157 (3), 721-740, 1976 | 204* | 1976 |
| Interaction of the antitumor drug 4'-(9-acridinylamino) methanesulfon-m-anisidide and related acridines with nucleic acids WR WILSON, BC BAGULEY, LPG WAKELIN, MJ WARING Molecular Pharmacology 20 (2), 404-414, 1981 | 141 | 1981 |
| Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino) ethyl] acridine-4-carboxamide bound to the DNA hexanucleotide d (CGTACG) 2 A Adams, JM Guss, CA Collyer, WA Denny, LPG Wakelin Biochemistry 38 (29), 9221-9233, 1999 | 135 | 1999 |
| Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents LPG Wakelin, GJ Atwell, GW Rewcastle, WA Denny Journal of medicinal chemistry 30 (5), 855-861, 1987 | 135 | 1987 |
| Structural limitations on the bifunctional intercalation of diacridines into DNA LPG Wakelin, M Romanos, TK Chen, D Glaubiger, ES Canellakis, ... Biochemistry 17 (23), 5057-5063, 1978 | 135 | 1978 |
| Major Groove Binding and ‘DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide … AK Todd, A Adams, JH Thorpe, WA Denny, LPG Wakelin, CJ Cardin Journal of medicinal chemistry 42 (4), 536-540, 1999 | 134 | 1999 |
| DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard TA Gourdie, KK Valu, GL Gravatt, TJ Boritzki, BC Baguley, LPG Wakelin, ... Journal of medicinal chemistry 33 (4), 1177-1186, 1990 | 131 | 1990 |
| Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity WA Denny, GJ Atwell, BC Baguley, LPG Wakelin Journal of medicinal chemistry 28 (11), 1568-1574, 1985 | 129 | 1985 |
| Activity of platinum (II) intercalating agents against murine leukemia L1210 WD McFadyen, LPG Wakelin, IAG Roos, VA Leopold Journal of medicinal chemistry 28 (8), 1113-1116, 1985 | 128 | 1985 |
| NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d (5'-GCATGC) 2 MS Searle, JG Hall, WA Denny, LPG Wakelin Biochemistry 27 (12), 4340-4349, 1988 | 122 | 1988 |
| DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards AS Prakash, WA Denny, TA Gourdie, KK Valu, PD Woodgate, ... Biochemistry 29 (42), 9799-9807, 1990 | 109 | 1990 |
| Kinetics of drug-DNA interaction: dependence of the binding mechanism on structure of the ligand LPG Wakelin, MJ Waring Journal of molecular biology 144 (2), 183-214, 1980 | 105 | 1980 |
| DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1, 2-diaminoethane) dichloroplatinum (II) HH Lee, BD Palmer, BC Baguley, M Chin, WD McFadyen, G Wickham, ... Journal of Medicinal Chemistry 35 (16), 2983-2987, 1992 | 102 | 1992 |
| α-PNA: a novel peptide nucleic acid analogue of DNA NM Howarth, LPG Wakelin The Journal of organic chemistry 62 (16), 5441-5450, 1997 | 101 | 1997 |
| DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine BD Palmer, HH Lee, P Johnson, BC Baguley, G Wickham, LPG Wakelin, ... Journal of medicinal chemistry 33 (11), 3008-3014, 1990 | 94 | 1990 |
| Bisintercalating threading diacridines: relationships between DNA binding, cytotoxicity, and cell cycle arrest LPG Wakelin, X Bu, A Eleftheriou, A Parmar, C Hayek, BW Stewart Journal of medicinal chemistry 46 (26), 5790-5802, 2003 | 89 | 2003 |
| The unwinding of circular deoxyribonucleic acid by phenanthridinium drugs: structure-activity relations for the intercalation reaction LPG Wakelin, MJ Waring Molecular Pharmacology 10 (3), 544-561, 1974 | 88 | 1974 |
| Effects of ring substituents and linker chains on the bifunctional intercalation of diacridines into deoxyribonucleic acid RGMR Wright, LPG Wakelin, A Fieldes, RM Acheson, MJ Waring Biochemistry 19 (25), 5825-5836, 1980 | 87 | 1980 |
William A DennyDistinguished Professor, The University of AucklandEmail verificata su auckland.ac.nz
