| Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial W Hueber, BE Sands, S Lewitzky, M Vandemeulebroecke, W Reinisch, ... Gut 61 (12), 1693-1700, 2012 | 1540 | 2012 |
| Reduced Paneth cell α-defensins in ileal Crohn's disease J Wehkamp, NH Salzman, E Porter, S Nuding, M Weichenthal, RE Petras, ... Proceedings of the National Academy of Sciences 102 (50), 18129-18134, 2005 | 1298 | 2005 |
| NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression J Wehkamp, J Harder, M Weichenthal, M Schwab, E Schäffeler, M Schlee, ... Gut 53 (11), 1658-1664, 2004 | 1123 | 2004 |
| A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon K Fellermann, DE Stange, E Schaeffeler, H Schmalzl, J Wehkamp, ... The American Journal of Human Genetics 79 (3), 439-448, 2006 | 711 | 2006 |
| NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium J Wehkamp, J Harder, K Wehkamp, BW Meissner, M Schlee, C Enders, ... Infection and immunity 72 (10), 5750-5758, 2004 | 672 | 2004 |
| Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1 BO Schroeder, Z Wu, S Nuding, S Groscurth, M Marcinowski, J Beisner, ... Nature 469 (7330), 419-423, 2011 | 551 | 2011 |
| Intestinal barrier in inflammatory bowel disease L Antoni, S Nuding, J Wehkamp, EF Stange World journal of gastroenterology: WJG 20 (5), 1165, 2014 | 485 | 2014 |
| Probiotic lactobacilli and VSL# 3 induce enterocyte β-defensin 2 M Schlee, J Harder, B Köten, EF Stange, J Wehkamp, K Fellermann Clinical & Experimental Immunology 151 (3), 528-535, 2008 | 467 | 2008 |
| Inducible and constitutive β-defensins are differentially expressed in Crohn's disease and ulcerative colitis J Wehkamp, J Harder, M Weichenthal, O Mueller, KR Herrlinger, ... Inflammatory bowel diseases 9 (4), 215-223, 2003 | 461 | 2003 |
| NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2 E Voss, J Wehkamp, K Wehkamp, EF Stange, JM Schröder, J Harder Journal of Biological Chemistry 281 (4), 2005-2011, 2006 | 424 | 2006 |
| Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin M Schlee, J Wehkamp, A Altenhoefer, TA Oelschlaeger, EF Stange, ... Infection and immunity 75 (5), 2399-2407, 2007 | 422 | 2007 |
| Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets H Chu, M Pazgier, G Jung, SP Nuccio, PA Castillo, MF De Jong, ... Science 337 (6093), 477-481, 2012 | 405 | 2012 |
| A ntimicrobial peptides and gut microbiota in homeostasis and pathology MJ Ostaff, EF Stange, J Wehkamp EMBO molecular medicine 5 (10), 1465-1483, 2013 | 341 | 2013 |
| The Paneth cell α-defensin deficiency of ileal Crohn’s disease is linked to Wnt/Tcf-4 J Wehkamp, G Wang, I Kubler, S Nuding, A Gregorieff, A Schnabel, ... The Journal of Immunology 179 (5), 3109-3118, 2007 | 341 | 2007 |
| Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis M Gersemann, S Becker, I Kübler, M Koslowski, G Wang, KR Herrlinger, ... Differentiation 77 (1), 84-94, 2009 | 316 | 2009 |
| Human β-defensin 2 but not β-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease J Wehkamp, K Fellermann, KR Herrlinger, S Baxmann, K Schmidt, ... European journal of gastroenterology & hepatology 14 (7), 745-752, 2002 | 275 | 2002 |
| Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense Z Teltschik, R Wiest, J Beisner, S Nuding, C Hofmann, J Schoelmerich, ... Hepatology 55 (4), 1154-1163, 2012 | 260 | 2012 |
| Crohn's disease: a defensin deficiency syndrome? K Fellermann, J Wehkamp, KR Herrlinger, EF Stange European journal of gastroenterology & hepatology 15 (6), 627-634, 2003 | 238 | 2003 |
| Mechanisms of disease: defensins in gastrointestinal diseases J Wehkamp, K Fellermann, KR Herrlinger, CL Bevins, EF Stange Nature clinical practice Gastroenterology & hepatology 2 (9), 406-415, 2005 | 236 | 2005 |
| Inflammatory bowel disease: Crohn’s disease and ulcerative colitis J Wehkamp, M Götz, K Herrlinger, W Steurer, EF Stange Deutsches Ärzteblatt International 113 (5), 72, 2016 | 232 | 2016 |
