Brian Blagg
Brian Blagg
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Cited by
Cited by
Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket
A Donnelly, BSJ Blagg
Current medicinal chemistry 15 (26), 2702-2717, 2008
Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90
JA Burlison, L Neckers, AB Smith, A Maxwell, BSJ Blagg
Journal of the American Chemical Society 128 (48), 15529-15536, 2006
Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation
BSJ Blagg, TD Kerr
Medicinal research reviews 26 (3), 310-338, 2006
Hsp90 inhibitors identified from a library of novobiocin analogues
XM Yu, G Shen, L Neckers, H Blake, J Holzbeierlein, B Cronk, BSJ Blagg
Journal of the American Chemical Society 127 (37), 12778-12779, 2005
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
M Mollapour, S Tsutsumi, AC Donnelly, K Beebe, MJ Tokita, MJ Lee, ...
Molecular cell 37 (3), 333-343, 2010
Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents
H Zhao, AC Donnelly, BR Kusuma, GEL Brandt, D Brown, RA Rajewski, ...
Journal of medicinal chemistry 54 (11), 3839-3853, 2011
E. coli MEP Synthase:  Steady-State Kinetic Analysis and Substrate Binding
AT Koppisch, DT Fox, BSJ Blagg, CD Poulter
Biochemistry 41 (1), 236-243, 2002
Gedunin, a novel Hsp90 inhibitor: semisynthesis of derivatives and preliminary structure− activity relationships
GEL Brandt, MD Schmidt, TE Prisinzano, BSJ Blagg
Journal of medicinal chemistry 51 (20), 6495-6502, 2008
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity
AC Donnelly, JR Mays, JA Burlison, JT Nelson, G Vielhauer, ...
The Journal of organic chemistry 73 (22), 8901-8920, 2008
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines
JA Burlison, C Avila, G Vielhauer, DJ Lubbers, J Holzbeierlein, BSJ Blagg
The Journal of organic chemistry 73 (6), 2130-2137, 2008
A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity
S Ansar, JA Burlison, MK Hadden, XM Yu, KE Desino, J Bean, L Neckers, ...
Bioorganic & medicinal chemistry letters 17 (7), 1984-1990, 2007
Intramolecular Diels− Alder and tandem intramolecular Diels− Alder/1, 3-dipolar cycloaddition reactions of 1, 3, 4-oxadiazoles
GD Wilkie, GI Elliott, BSJ Blagg, SE Wolkenberg, DR Soenen, MM Miller, ...
Journal of the American Chemical Society 124 (38), 11292-11294, 2002
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦
CA Patwardhan, A Fauq, LB Peterson, C Miller, BSJ Blagg, A Chadli
Journal of Biological Chemistry 288 (10), 7313-7325, 2013
Intramolecular Diels− Alder/1, 3-dipolar cycloaddition cascade of 1, 3, 4-oxadiazoles
GI Elliott, JR Fuchs, BSJ Blagg, H Ishikawa, H Tao, ZQ Yuan, DL Boger
Journal of the American Chemical Society 128 (32), 10589-10595, 2006
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells
SN Shelton, ME Shawgo, SB Matthews, Y Lu, AC Donnelly, K Szabla, ...
Molecular pharmacology 76 (6), 1314-1322, 2009
1-Deoxy-d-Xylulose 5-Phosphate Synthase, the Gene Product of Open Reading Frame (ORF) 2816 and ORF 2895 inRhodobacter capsulatus
FM Hahn, LM Eubanks, CA Testa, BSJ Blagg, JA Baker, CD Poulter
Journal of bacteriology 183 (1), 1-11, 2001
Gambogic acid, a natural product inhibitor of Hsp90
J Davenport, JR Manjarrez, L Peterson, B Krumm, BSJ Blagg, RL Matts
Journal of natural products 74 (5), 1085-1092, 2011
Synthesis and evaluation of coumermycin A1 analogues that inhibit the Hsp90 protein folding machinery
JA Burlison, BSJ Blagg
Organic letters 8 (21), 4855-4858, 2006
Synthesis and evaluation of electron-rich curcumin analogues
MW Amolins, LB Peterson, BSJ Blagg
Bioorganic & medicinal chemistry 17 (1), 360-367, 2009
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
B Blagg, ML Michaelis, M McIntosh
US Patent 7,622,451, 2009
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