A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling F Destro, M Barolo International Journal of Pharmaceutics 620, 121715, 2022 | 72 | 2022 |
A hybrid framework for process monitoring: Enhancing data-driven methodologies with state and parameter estimation F Destro, P Facco, SG Munoz, F Bezzo, M Barolo Journal of Process Control 92, 333-351, 2020 | 36 | 2020 |
Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing F Destro, I Hur, V Wang, M Abdi, X Feng, E Wood, S Coleman, P Firth, ... Chemical engineering science 244, 116803, 2021 | 27 | 2021 |
Powder composition monitoring in continuous pharmaceutical solid-dosage form manufacturing using state estimation–Proof of concept F Destro, SG Muñoz, F Bezzo, M Barolo International Journal of Pharmaceutics 605, 120808, 2021 | 15 | 2021 |
A benchmark simulator for quality-by-design and quality-by-control studies in continuous pharmaceutical manufacturing‒Intensified filtration-drying of crystallization slurries F Destro, ZK Nagy, M Barolo Computers & chemical engineering 163, 107809, 2022 | 13 | 2022 |
Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system F Destro, J Joseph, P Srinivasan, JM Kanter, C Neufeld, JM Wolfrum, ... Molecular Therapy-Methods & Clinical Development 30, 122-146, 2023 | 12 | 2023 |
Quality‐by‐control of intensified continuous filtration‐drying of active pharmaceutical ingredients F Destro, M Barolo, ZK Nagy AIChE Journal 69 (2), e17926, 2023 | 10 | 2023 |
Monitoring a segmented fluid bed dryer by hybrid data-driven/knowledge-driven modeling F Destro, AJ Salmon, P Facco, CC Pantelides, F Bezzo, M Barolo IFAC-PapersOnLine 53 (2), 11638-11643, 2020 | 10 | 2020 |
Analysis of Poly (ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding model EZL Zhong-Johnson, Z Dong, CT Canova, F Destro, M Cañellas, ... Journal of Biological Chemistry 300 (3), 2024 | 8 | 2024 |
Digital design of an integrated purification system for continuous pharmaceutical manufacturing I Hur, D Casas-Orozco, DJ Laky, F Destro, ZK Nagy Chemical Engineering Science 285, 119534, 2024 | 4 | 2024 |
Integrated synthesis, crystallization, filtration, and drying of active pharmaceutical ingredients: a model-based digital design framework for process optimization and control DJ Laky, D Casas-Orozco, F Destro, M Barolo, GV Reklaitis, ZK Nagy Optimization of Pharmaceutical Processes, 253-287, 2022 | 4 | 2022 |
Continuous integrated filtration, washing and drying of aspirin: digital design of a novel intensified unit F Destro, V Wang, M Abdi, X Feng, E Wood, S Coleman, P Firth, A Barton, ... IFAC-PapersOnLine 54 (3), 134-139, 2021 | 3 | 2021 |
Advanced methodologies for model-based optimization and control of pharmaceutical processes F Destro, PK Inguva, P Srisuma, RD Braatz Current Opinion in Chemical Engineering 45, 101035, 2024 | 1 | 2024 |
Efficient simulation of viral transduction and propagation for biomanufacturing F Destro, RD Braatz ACS Synthetic Biology, 2024 | 1 | 2024 |
The state of technological advancement to address challenges in the manufacture of rAAV gene therapies F Destro, W Wu, P Srinivasan, J Joseph, V Bal, C Neufeld, JM Wolfrum, ... Biotechnology Advances, 108433, 2024 | | 2024 |
Mechanistic Modeling to Enhance Production of Recombinant Adeno-Associated Virus with Insect Cells F Destro, J Joseph, P Srinivasan, J Kanter, C Neufeld, JM Wolfrum, ... 2023 AIChE Annual Meeting, 2023 | | 2023 |
Efficient Numerical Strategies for Multidimensional Population Balance Models and Transport Equations P Inguva, F Destro, R Braatz 2023 AIChE Annual Meeting, 2023 | | 2023 |
Model-Based Optimization of Continuous Manufacturing with the Baculovirus Expression Vector System F Destro, J Joseph, L Paoli, P Srinivasan, J Kanter, C Neufeld, ... 2023 AIChE Annual Meeting, 2023 | | 2023 |
Introducing ContCarSim, a benchmark simulator for design and control of continuous integrated filtration-drying of crystallization slurries F Destro, M Barolo, ZK Nagy 2022 AIChE Annual Meeting, 2023 | | 2023 |
Model-based monitoring of an intensified unit for continuous pharmaceutical filtration-drying F Destro, M Barolo, ZK Nagy Computer Aided Chemical Engineering 49, 1405-1410, 2022 | | 2022 |