| Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis M Njoroge, NM Njuguna, P Mutai, DSB Ongarora, PW Smith, K Chibale Chemical reviews 114 (22), 11138-11163, 2014 | 124 | 2014 |
| Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration R van der Westhuyzen, S Winks, CR Wilson, GA Boyle, RK Gessner, ... Journal of Medicinal Chemistry 58 (23), 9371-9381, 2015 | 93 | 2015 |
| Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents F Mjambili, M Njoroge, K Naran, C De Kock, PJ Smith, V Mizrahi, ... Bioorganic & medicinal chemistry letters 24 (2), 560-564, 2014 | 76 | 2014 |
| UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ... Antimicrobial agents and chemotherapy 62 (9), 10.1128/aac. 00012-18, 2018 | 62 | 2018 |
| Synthesis and structure–activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2 RK Sharma, Y Younis, G Mugumbate, M Njoroge, J Gut, PJ Rosenthal, ... European journal of medicinal chemistry 90, 507-518, 2015 | 56 | 2015 |
| Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors E Yoo, BH Stokes, H De Jong, M Vanaerschot, TRS Kumar, N Lawrence, ... Journal of the American Chemical Society 140 (36), 11424-11437, 2018 | 55 | 2018 |
| Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in … K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ... Journal of medicinal chemistry 60 (4), 1432-1448, 2017 | 51 | 2017 |
| Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors … N Kandepedu, D Gonzàlez Cabrera, S Eedubilli, D Taylor, C Brunschwig, ... Journal of medicinal chemistry 61 (13), 5692-5703, 2018 | 37 | 2018 |
| Antimalarial Pyrido[1,2-a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping … J Okombo, C Brunschwig, K Singh, GA Dziwornu, L Barnard, M Njoroge, ... ACS infectious diseases 5 (3), 372-384, 2019 | 35 | 2019 |
| A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship … C Le Manach, T Paquet, C Brunschwig, M Njoroge, Z Han, ... Journal of medicinal chemistry 58 (21), 8713-8722, 2015 | 30 | 2015 |
| Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents M Tukulula, M Njoroge, GC Mugumbate, J Gut, PJ Rosenthal, S Barteau, ... Bioorganic & medicinal chemistry 21 (17), 4904-4913, 2013 | 30 | 2013 |
| Antimalarial benzoheterocyclic 4-aminoquinolines: structure–activity relationship, in vivo evaluation, mechanistic and bioactivation studies DSB Ongarora, N Strydom, K Wicht, M Njoroge, L Wiesner, TJ Egan, ... Bioorganic & medicinal chemistry 23 (17), 5419-5432, 2015 | 29 | 2015 |
| Semisynthetic antimycobacterial C-3 Silicate and C-3/C-21 ester derivatives of fusidic acid: Pharmacological evaluation and stability studies in liver microsomes, rat plasma … M Njoroge, G Kaur, M Espinoza-Moraga, A Wasuna, GA Dziwornu, ... ACS Infectious Diseases 5 (9), 1634-1644, 2019 | 26 | 2019 |
| Azaaurones as potent antimycobacterial agents active against MDR‐and XDR‐TB A Campaniço, MP Carrasco, M Njoroge, R Seldon, K Chibale, J Perdigão, ... ChemMedChem 14 (16), 1537-1546, 2019 | 24 | 2019 |
| Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile … S Louw, M Njoroge, N Chigorimbo‐Murefu, K Chibale Rapid Communications in Mass Spectrometry 26 (20), 2431-2442, 2012 | 24 | 2012 |
| Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents M Espinoza-Moraga, K Singh, M Njoroge, G Kaur, J Okombo, C De Kock, ... Bioorganic & medicinal chemistry letters 27 (3), 658-661, 2017 | 23 | 2017 |
| Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγnull Mouse … AT Nchinda, C Le Manach, T Paquet, D Gonzàlez Cabrera, KJ Wicht, ... Journal of medicinal chemistry 61 (9), 4213-4227, 2018 | 22 | 2018 |
| Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation J Okombo, K Singh, G Mayoka, F Ndubi, L Barnard, PM Njogu, M Njoroge, ... ACS infectious diseases 3 (6), 411-420, 2017 | 22 | 2017 |
| Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites EM Kigondu, M Njoroge, K Singh, N Njuguna, DF Warner, K Chibale MedChemComm 5 (4), 502-506, 2014 | 22 | 2014 |
| Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds M Tukulula, M Njoroge, ET Abay, GC Mugumbate, L Wiesner, D Taylor, ... ACS medicinal chemistry letters 4 (12), 1198-1202, 2013 | 22 | 2013 |
Timothy J EganProfessor of Chemistry, University of Cape TownEmail verificata su uct.ac.za
