| Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria HX Deng, Y Shi, Y Furukawa, H Zhai, R Fu, E Liu, GH Gorrie, MS Khan, ... Proceedings of the National Academy of Sciences 103 (18), 7142-7147, 2006 | 528 | 2006 |
| Oxygen‐induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS Y Furukawa, AS Torres, TV O'Halloran The EMBO journal 23 (14), 2872-2881, 2004 | 439 | 2004 |
| The unusually stable quaternary structure of human Cu, Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status F Arnesano, L Banci, I Bertini, M Martinelli, Y Furukawa, TV O'Halloran Journal of Biological Chemistry 279 (46), 47998-48003, 2004 | 314 | 2004 |
| Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo-and reduced form of SOD1, leading to unfolding and oxidative aggregation Y Furukawa, TV O'Halloran Journal of Biological Chemistry 280 (17), 17266-17274, 2005 | 307 | 2005 |
| Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria LS Field, Y Furukawa, TV O'Halloran, VC Culotta Journal of Biological Chemistry 278 (30), 28052-28059, 2003 | 288 | 2003 |
| A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions*♦ Y Furukawa, K Kaneko, S Watanabe, K Yamanaka, N Nukina Journal of Biological Chemistry 286 (21), 18664-18672, 2011 | 270 | 2011 |
| Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice Y Furukawa, R Fu, HX Deng, T Siddique, TV O'Halloran Proceedings of the National Academy of Sciences 103 (18), 7148-7153, 2006 | 268 | 2006 |
| Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis Y Furukawa, K Kaneko, K Yamanaka, TV O'Halloran, N Nukina Journal of Biological Chemistry 283 (35), 24167-24176, 2008 | 244 | 2008 |
| Posttranslational modifications in Cu, Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis Y Furukawa, TV O'halloran Antioxidants & redox signaling 8 (5-6), 847-867, 2006 | 189 | 2006 |
| RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells H Doi, K Okamura, PO Bauer, Y Furukawa, H Shimizu, M Kurosawa, ... Journal of Biological Chemistry 283 (10), 6489-6500, 2008 | 147 | 2008 |
| Intranuclear aggregation of mutant FUS/TLS as a molecular pathomechanism of amyotrophic lateral sclerosis T Nomura, S Watanabe, K Kaneko, K Yamanaka, N Nukina, Y Furukawa Journal of Biological Chemistry 289 (2), 1192-1202, 2014 | 146 | 2014 |
| Regulatory role of RNA chaperone TDP-43 for RNA misfolding and repeat-associated translation in SCA31 T Ishiguro, N Sato, M Ueyama, N Fujikake, C Sellier, A Kanegami, ... Neuron 94 (1), 108-124. e7, 2017 | 123 | 2017 |
| Mutation-dependent polymorphism of Cu, Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis Y Furukawa, K Kaneko, K Yamanaka, N Nukina Journal of Biological Chemistry 285 (29), 22221-22231, 2010 | 109 | 2010 |
| Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases Y Furukawa, K Kaneko, G Matsumoto, M Kurosawa, N Nukina Journal of Neuroscience 29 (16), 5153-5162, 2009 | 103 | 2009 |
| Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations E Tokuda, Y Furukawa International journal of molecular sciences 17 (5), 636, 2016 | 83 | 2016 |
| Local unfolding of Cu, Zn superoxide dismutase monomer determines the morphology of fibrillar aggregates F Ding, Y Furukawa, N Nukina, NV Dokholyan Journal of molecular biology 421 (4-5), 548-560, 2012 | 82 | 2012 |
| Disulfide scrambling describes the oligomer formation of superoxide dismutase (SOD1) proteins in the familial form of amyotrophic lateral sclerosis K Toichi, K Yamanaka, Y Furukawa Journal of Biological Chemistry 288 (7), 4970-4980, 2013 | 81 | 2013 |
| Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment A Okuzumi, M Kurosawa, T Hatano, M Takanashi, S Nojiri, T Fukuhara, ... Acta Neuropathologica Communications 6, 1-15, 2018 | 74 | 2018 |
| Tau protein assembles into isoform-and disulfide-dependent polymorphic fibrils with distinct structural properties Y Furukawa, K Kaneko, N Nukina Journal of Biological Chemistry 286 (31), 27236-27246, 2011 | 69 | 2011 |
| Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals Y Tamaki, A Shodai, T Morimura, R Hikiami, S Minamiyama, T Ayaki, ... Scientific reports 8 (1), 6030, 2018 | 68 | 2018 |
