Emma T van der Westhuizen
Emma T van der Westhuizen
Research Fellow, Drug Discovery Biology, Monash University
Verified email at monash.edu - Homepage
Cited by
Cited by
Relaxin family peptides and their receptors
RAD Bathgate, ML Halls, ET Van Der Westhuizen, GE Callander, ...
Physiological reviews 93 (1), 405-480, 2013
Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy
ET van der Westhuizen, B Breton, A Christopoulos, M Bouvier
Molecular pharmacology 85 (3), 492-509, 2014
Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment.
Tilakaratne N, Christopoulos G, Zumpe ET, Foord SM, Sexton PM
J Pharmacol Exp Ther 294 (1), 61-72, 2000
Relaxin family peptide receptors–former orphans reunite with their parent ligands to activate multiple signalling pathways
ML Halls, ET Van Der Westhuizen, RAD Bathgate, RJ Summers
British journal of pharmacology 150 (6), 677-691, 2007
Impedance responses reveal β2-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profiles
W Stallaert, JF Dorn, E Van Der Westhuizen, M Audet, M Bouvier
PloS one 7 (1), e29420, 2012
Endogenous allosteric modulators of G protein–coupled receptors
ET van der Westhuizen, C Valant, PM Sexton, A Christopoulos
Journal of Pharmacology and Experimental Therapeutics 353 (2), 246-260, 2015
FSH-regulated gene expression profiles in ovarian tumours and normal ovaries.
Chu S, Rushdi S, Zumpe ET, Mamers P, Healy DL, Jobling T, Burger HG, Fuller PJ
Mol Hum Reprod 8 (5), 426-33, 2002
Structural insights into binding specificity, efficacy and bias of a β 2 AR partial agonist
M Masureel, Y Zou, LP Picard, E van der Westhuizen, JP Mahoney, ...
Nature chemical biology 14 (11), 1059-1066, 2018
The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism
ET van der Westhuizen, TD Werry, PM Sexton, RJ Summers
Molecular pharmacology 71 (6), 1618-1629, 2007
Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.
Zumpe ET, Tilakaratne N, Fraser NJ, Christopoulos G, Foord SM, Sexton PM
Biochem Biophys Res Commun. 267 (1), 368-72, 2000
Relaxin family peptide receptors–from orphans to therapeutic targets
ET van der Westhuizen, ML Halls, CS Samuel, RAD Bathgate, ...
Drug discovery today 13 (15-16), 640-651, 2008
Inhibin-activin receptor subunit gene expression in ovarian tumors.
Fuller PJ, Zumpe ET, Chu S, Mamers P, Burger HG
J Clin Endocrinol Metab 87 (3), 1395-401, 2002
Responses of GPCR135 to human gene 3 (H3) relaxin in CHO‐K1 cells determined by microphysiometry
ET Van Der Westhuizen, PM Sexton, RAD Bathgate, RJ Summers
Annals of the New York Academy of Sciences 1041 (1), 332-337, 2005
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3)
ET van der Westhuizen, A Christopoulos, PM Sexton, JD Wade, ...
Molecular pharmacology 77 (5), 759-772, 2010
Relaxin receptors-new drug targets for multiple disease states
ET Van Der Westhuizen, RJ Summers, ML Halls, RA D Bathgate, ...
Current drug targets 8 (1), 91-104, 2007
Purinergic receptor transactivation by the β2-adrenergic receptor increases intracellular Ca2+ in nonexcitable cells
W Stallaert, ET van der Westhuizen, AM Schönegge, B Plouffe, M Hogue, ...
Molecular pharmacology 91 (5), 533-544, 2017
Relaxin family peptide receptor (RXFP1) coupling to Gαi3 involves the C-terminal Arg752 and localization within membrane raft microdomains
ML Halls, ET van der Westhuizen, JD Wade, BA Evans, RAD Bathgate, ...
Molecular pharmacology 75 (2), 415-428, 2009
Crystal structure of the M5 muscarinic acetylcholine receptor
Z Vuckovic, PR Gentry, AE Berizzi, K Hirata, S Varghese, G Thompson, ...
Proceedings of the National Academy of Sciences 116 (51), 26001-26007, 2019
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response
B Benredjem, J Gallion, D Pelletier, P Dallaire, J Charbonneau, D Cawkill, ...
Nature communications 10 (1), 1-15, 2019
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak …
JCC Dallagnol, E Khajehali, ET van der Westhuizen, M Jörg, C Valant, ...
Journal of medicinal chemistry 61 (7), 2875-2894, 2018
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