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Gabriele Costantino
Gabriele Costantino
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6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
R Pellicciari, S Fiorucci, E Camaioni, C Clerici, G Costantino, PR Maloney, ...
Journal of medicinal chemistry 45 (17), 3569-3572, 2002
8582002
Generating optimal linear PLS estimations (GOLPE): an advanced chemometric tool for handling 3D‐QSAR problems
M Baroni, G Costantino, G Cruciani, D Riganelli, R Valigi, S Clementi
Quantitative Structure‐Activity Relationships 12 (1), 9-20, 1993
5801993
Target flexibility: an emerging consideration in drug discovery and design
P Cozzini, GE Kellogg, F Spyrakis, DJ Abraham, G Costantino, A Emerson, ...
Journal of medicinal chemistry 51 (20), 6237-6255, 2008
3552008
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure− activity relationship of a series of body and side chain modified analogues …
R Pellicciari, G Costantino, E Camaioni, BM Sadeghpour, A Entrena, ...
Journal of medicinal chemistry 47 (18), 4559-4569, 2004
2452004
1-Aminoindan-1, 5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors
R Pellicciari, R Luneia, G Costantino, M Marinozzi, B Natalini, P Jakobsen, ...
Journal of medicinal chemistry 38 (19), 3717-3719, 1995
1961995
Farnesoid X receptor: from structure to potential clinical applications
R Pellicciari, G Costantino, S Fiorucci
Journal of medicinal chemistry 48 (17), 5383-5403, 2005
1712005
(S)-(+)-2-(3‘-Carboxybicyclo[1.1.1]pentyl)- glycine, a Structurally New Group I Metabotropic Glutamate Receptor Antagonist
R Pellicciari, M Raimondo, M Marinozzi, B Natalini, G Costantino, ...
Journal of medicinal chemistry 39 (15), 2874-2876, 1996
1691996
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl) alanine, a potent inhibitor of …
R Pellicciari, B Natalini, G Costantino, MR Mahmoud, L Mattoli, ...
Journal of medicinal chemistry 37 (5), 647-655, 1994
1691994
Modeling of poly (ADP-ribose) polymerase (PARP) inhibitors. Docking of ligands and quantitative structure− activity relationship analysis
G Costantino, A Macchiarulo, E Camaioni, R Pellicciari
Journal of medicinal chemistry 44 (23), 3786-3794, 2001
1632001
Predictive ability of regression models. Part II: Selection of the best predictive PLS model
M Baroni, S Clementi, G Cruciani, G Costantino, D Riganelli, E Oberrauch
Journal of chemometrics 6 (6), 347-356, 1992
1551992
1, 4-Benzothiazine and 1, 4-benzoxazine imidazole derivatives with antifungal activity: a docking study
A Macchiarulo, G Costantino, D Fringuelli, A Vecchiarelli, F Schiaffella, ...
Bioorganic & medicinal chemistry 10 (11), 3415-3423, 2002
1472002
Recent advances in the synthetic chemistry of bicyclo [1.1. 1] pentane
J Kanazawa, M Uchiyama
Synlett 30 (01), 1-11, 2019
1282019
Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2‘-Carboxy-3‘-phenylcyclopropyl)glycine. Focus on (2S,1‘S,2‘S,3‘R)-2-(2 …
R Pellicciari, M Marinozzi, B Natalini, G Costantino, R Luneia, G Giorgi, ...
Journal of medicinal chemistry 39 (11), 2259-2269, 1996
1261996
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23-and 6, 23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein …
R Pellicciari, H Sato, A Gioiello, G Costantino, A Macchiarulo, ...
Journal of medicinal chemistry 50 (18), 4265-4268, 2007
1232007
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors
G Eren, S Ünlü, MT Nuņez, L Labeaga, F Ledo, A Entrena, E Banoğlu, ...
Bioorganic & medicinal chemistry 18 (17), 6367-6376, 2010
1202010
Synthesis and biological evaluation of 2-(3′-(1H-tetrazol-5-yl) bicyclo [1.1. 1] pent-1-yl) glycine (S-TBPG), a novel mGlu1 receptor antagonist
G Costantino, K Maltoni, M Marinozzi, E Camaioni, L Prezeau, JP Pin, ...
Bioorganic & medicinal chemistry 9 (2), 221-227, 2001
962001
Modulators of the kynurenine pathway of triptophan metabolism. Synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl) benzoylalanine, the first potent and …
R Pellicciari, R Rizzo, G Costantino, M Marinozzi, L Amori, P Guidetti, ...
ChemMedChem 1 (5), 528-531, 2006
882006
Novel isoquinolinone-derived inhibitors of poly (ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia
A Chiarugi, E Meli, M Calvani, R Picca, R Baronti, E Camaioni, ...
Journal of Pharmacology and Experimental Therapeutics 305 (3), 943-949, 2003
872003
On the way to selective PARP‐2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives
R Pellicciari, E Camaioni, G Costantino, L Formentini, P Sabbatini, ...
ChemMedChem: Chemistry Enabling Drug Discovery 3 (6), 914-923, 2008
862008
Predictive binding of. beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach
MS Allen, AJ LaLoggia, LJ Dorn, MJ Martin, G Costantino, TJ Hagen, ...
Journal of medicinal chemistry 35 (22), 4001-4010, 1992
841992
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