| Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors SWJ Ember, JY Zhu, SH Olesen, MP Martin, A Becker, N Berndt, GI Georg, ... ACS chemical biology 9 (5), 1160-1171, 2014 | 240 | 2014 |
| A novel approach to the discovery of small‐molecule ligands of CDK2 MP Martin, R Alam, S Betzi, DJ Ingles, JY Zhu, E Schönbrunn Chembiochem 13 (14), 2128-2136, 2012 | 90 | 2012 |
| Structural basis of wee kinases functionality and inactivation by diverse small molecule inhibitors JY Zhu, RA Cuellar, N Berndt, HE Lee, SH Olesen, MP Martin, JT Jensen, ... Journal of medicinal chemistry 60 (18), 7863-7875, 2017 | 77 | 2017 |
| Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors HR Lawrence, MP Martin, Y Luo, R Pireddu, H Yang, H Gevariya, ... Journal of medicinal chemistry 55 (17), 7392-7416, 2012 | 75 | 2012 |
| Molecular basis for the N-terminal bromodomain-and-extra-terminal-family selectivity of a dual kinase–bromodomain inhibitor A Divakaran, SK Talluri, AM Ayoub, NK Mishra, H Cui, JC Widen, ... Journal of medicinal chemistry 61 (20), 9316-9334, 2018 | 70 | 2018 |
| A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A MP Martin, JY Zhu, HR Lawrence, R Pireddu, Y Luo, R Alam, S Ozcan, ... ACS chemical biology 7 (4), 698-706, 2012 | 67 | 2012 |
| Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) JY Zhu, Y Yang, H Han, S Betzi, SH Olesen, F Marsilio, E Schönbrunn Journal of Biological Chemistry 287 (16), 12657-12667, 2012 | 61 | 2012 |
| Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors R Li, MP Martin, Y Liu, B Wang, RA Patel, JY Zhu, N Sun, R Pireddu, ... Journal of medicinal chemistry 55 (5), 2474-2478, 2012 | 61 | 2012 |
| Structural basis of ALDH1A2 inhibition by irreversible and reversible small molecule inhibitors Y Chen, JY Zhu, KH Hong, DC Mikles, GI Georg, AS Goldstein, JK Amory, ... ACS chemical biology 13 (3), 582-590, 2017 | 56 | 2017 |
| Synthesis and evaluation of eight-and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and … JC Lee, S Francis, D Dutta, V Gupta, Y Yang, JY Zhu, JS Tash, ... The Journal of organic chemistry 77 (7), 3082-3098, 2012 | 54 | 2012 |
| Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) R Pireddu, KD Forinash, NN Sun, MP Martin, SS Sung, B Alexander, ... MedChemComm 3 (6), 699-709, 2012 | 51 | 2012 |
| Potent dual BET bromodomain-kinase inhibitors as value-added multitargeted chemical probes and cancer therapeutics SW Ember, QT Lambert, N Berndt, S Gunawan, M Ayaz, M Tauro, JY Zhu, ... Molecular cancer therapeutics 16 (6), 1054-1067, 2017 | 48 | 2017 |
| BET bromodomain inhibitors with one-step synthesis discovered from virtual screen AM Ayoub, LML Hawk, RJ Herzig, J Jiang, AJ Wisniewski, CT Gee, ... Journal of medicinal chemistry 60 (12), 4805-4817, 2017 | 47 | 2017 |
| Identification of a novel class of BRD4 inhibitors by computational screening and binding simulations BK Allen, S Mehta, SWJ Ember, JY Zhu, E Schönbrunn, NG Ayad, ... ACS omega 2 (8), 4760-4771, 2017 | 34 | 2017 |
| Discovery of diverse small‐molecule inhibitors of mammalian sterile20‐like kinase 3 (MST3) SH Olesen, JY Zhu, MP Martin, E Schönbrunn ChemMedChem 11 (11), 1137-1144, 2016 | 27 | 2016 |
| Structural basis of inhibitor selectivity in the BRD7/9 subfamily of bromodomains RM Karim, A Chan, JY Zhu, E Schönbrunn Journal of medicinal chemistry 63 (6), 3227-3237, 2020 | 22 | 2020 |
| Assessment of bromodomain target engagement by a series of BI2536 analogues with miniaturized BET‐BRET LW Koblan, DL Buckley, CJ Ott, ME Fitzgerald, SWJ Ember, JY Zhu, S Liu, ... ChemMedChem 11 (23), 2575-2581, 2016 | 20 | 2016 |
| Structure–Activity Studies of N‐Butyl‐1‐deoxynojirimycin (NB‐DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2 X Gu, V Gupta, Y Yang, JY Zhu, EJ Carlson, C Kingsley, JS Tash, ... ChemMedChem 12 (23), 1977-1984, 2017 | 18 | 2017 |
| Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2 SH Olesen, DJ Ingles, JY Zhu, MP Martin, S Betzi, GI Georg, JS Tash, ... Molecules 20 (1), 1643-1660, 2015 | 15 | 2015 |
| Differential BET bromodomain inhibition by dihydropteridinone and pyrimidodiazepinone kinase inhibitors RM Karim, MJ Bikowitz, A Chan, JY Zhu, D Grassie, A Becker, N Berndt, ... Journal of medicinal chemistry 64 (21), 15772-15786, 2021 | 12 | 2021 |
