Gilberto Spadoni
Gilberto Spadoni
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2-[N-Acylamino(C1−C3)alkyl]indoles as MT1 Melatonin Receptor Partial Agonists, Antagonists, and Putative Inverse Agonists
G Spadoni, C Balsamini, A Bedini, G Diamantini, B Di Giacomo, A Tontini, ...
Journal of medicinal chemistry 41 (19), 3624-3634, 1998
Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice
J LoVerme, A Duranti, A Tontini, G Spadoni, M Mor, S Rivara, N Stella, ...
Bioorganic & medicinal chemistry letters 19 (3), 639-643, 2009
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study
M Mor, S Rivara, C Silva, F Bordi, PV Plazzi, G Spadoni, G Diamantini, ...
Journal of medicinal chemistry 41 (20), 3831-3844, 1998
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity
G Spadoni, B Stankov, A Duranti, G Biella, V Lucini, A Salvatori, ...
Journal of medicinal chemistry 36 (25), 4069-4074, 1993
Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
R Ochoa-Sanchez, S Comai, B Lacoste, FR Bambico, ...
Journal of Neuroscience 31 (50), 18439-18452, 2011
Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study
G Spadoni, C Balsamini, G Diamantini, B Di Giacomo, G Tarzia, M Mor, ...
Journal of medicinal chemistry 40 (13), 1990-2002, 1997
M Mor, PV Plazzi, G Spadoni, G Tarzia
Current medicinal chemistry 6 (6), 501-518, 1999
Analysis of Structure−Activity Relationships for MT2 Selective Antagonists by Melatonin MT1 and MT2 Receptor Models
S Rivara, S Lorenzi, M Mor, PV Plazzi, G Spadoni, A Bedini, G Tarzia
Journal of medicinal chemistry 48 (12), 4049-4060, 2005
N-(Substituted-anilinoethyl)amides: Design, Synthesis, and Pharmacological Characterization of a New Class of Melatonin Receptor Ligands
S Rivara, A Lodola, M Mor, A Bedini, G Spadoni, V Lucini, M Pannacci, ...
Journal of medicinal chemistry 50 (26), 6618-6626, 2007
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells
F Radogna, L Paternoster, MC Albertini, C Cerella, A Accorsi, A Bucchini, ...
Journal of pineal research 43 (2), 154-162, 2007
Melatonin receptor agonists: new options for insomnia and depression treatment
G Spadoni, A Bedini, S Rivara, M Mor
CNS neuroscience & therapeutics 17 (6), 733-741, 2011
Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders
S Rivara, M Mor, A Bedini, G Spadoni, G Tarzia
Current topics in medicinal chemistry 8 (11), 954-968, 2008
Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands
M Mor, G Spadoni, B Di Giacomo, G Diamantini, A Bedini, G Tarzia, ...
Bioorganic & medicinal chemistry 9 (4), 1045-1057, 2001
1-(2-Alkanamidoethyl)-6-methoxyindole derivatives: A new class of potent indole melatonin analogues
G Tarzia, G Diamantini, B Di Giacomo, G Spadoni, D Esposti, R Nonno, ...
Journal of medicinal chemistry 40 (13), 2003-2010, 1997
2-N-Acylaminoalkylindoles:  Design and Quantitative Structure−Activity Relationship Studies Leading to MT2-Selective Melatonin Antagonists
G Spadoni, C Balsamini, G Diamantini, A Tontini, G Tarzia, M Mor, ...
Journal of medicinal chemistry 44 (18), 2900-2912, 2001
Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways
M Lopez-Canul, E Palazzo, S Dominguez-Lopez, L Luongo, B Lacoste, ...
Pain 156 (2), 305-317, 2015
Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam
R Ochoa-Sanchez, Q Rainer, S Comai, G Spadoni, A Bedini, S Rivara, ...
Progress in neuro-psychopharmacology and biological psychiatry 39 (2), 318-325, 2012
Three-Dimensional Quantitative Structure−Activity Relationship Studies on Selected MT1 and MT2 Melatonin Receptor Ligands:  Requirements for Subtype …
S Rivara, M Mor, C Silva, V Zuliani, F Vacondio, G Spadoni, A Bedini, ...
Journal of medicinal chemistry 46 (8), 1429-1439, 2003
2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist
E Duranti, B Stankov, G Spadoni, A Duranti, V Lucini, S Capsoni, G Biella, ...
Life sciences 51 (7), 479-485, 1992
Recent advances in the development of melatonin MT1 and MT2 receptor agonists
M Mor, S Rivara, D Pala, A Bedini, G Spadoni, G Tarzia
Expert opinion on therapeutic patents 20 (8), 1059-1077, 2010
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