| Report on a novel emerging class of highly potent benzimidazole NPS opioids: chemical and in vitro functional characterization of isotonitazene P Blanckaert, A Cannaert, K Van Uytfanghe, F Hulpia, E Deconinck, ... Drug Testing and Analysis 12 (4), 422-430, 2020 | 73 | 2020 |
| Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness F Hulpia, D Mabille, GD Campagnaro, G Schumann, L Maes, I Roditi, ... Nature communications 10 (1), 5564, 2019 | 60 | 2019 |
| Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity F Hulpia, GD Campagnaro, M Scortichini, K Van Hecke, L Maes, ... European Journal of Medicinal Chemistry 164, 689-705, 2019 | 47 | 2019 |
| Discovery of Novel 7-Aryl 7-Deazapurine 3′-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi F Hulpia, K Van Hecke, C França da Silva, D da Gama Jaen Batista, ... Journal of Medicinal Chemistry 61 (20), 9287-9300, 2018 | 41 | 2018 |
| First report on brorphine: the next opioid on the deadly new psychoactive substance horizon? N Verougstraete, MM Vandeputte, C Lyphout, A Cannaert, F Hulpia, ... Journal of Analytical Toxicology 44 (9), 937-946, 2020 | 38 | 2020 |
| C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents F Hulpia, J Bouton, GD Campagnaro, IA Alfayez, D Mabille, L Maes, ... European Journal of Medicinal Chemistry 188, 112018, 2020 | 35 | 2020 |
| Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors L Song, R Merceron, B Gracia, AL Quintana, MDP Risseeuw, F Hulpia, ... Journal of Medicinal Chemistry 61 (7), 2753-2775, 2018 | 30 | 2018 |
| Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents C Lin, F Hulpia, CF da Silva, DGJ Batista, K Van Hecke, L Maes, G Caljon, ... Journal of Medicinal Chemistry 62 (19), 8847-8865, 2019 | 27 | 2019 |
| Structure–Activity Relationship Exploration of 3′-Deoxy-7-deazapurine Nucleoside Analogues as Anti-Trypanosoma brucei Agents F Hulpia, GD Campagnaro, KJ Alzahrani, IA Alfayez, MA Ungogo, ... ACS Infectious Diseases 6 (8), 2045-2056, 2020 | 24 | 2020 |
| Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei AH Alghamdi, JC Munday, GD Campagnaro, D Gurvic, F Svensson, ... Elife 9, e56416, 2020 | 21 | 2020 |
| New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma J Verhoeven, F Hulpia, K Kersemans, J Bolcaen, S De Lombaerde, ... Scientific Reports 9 (1), 2878, 2019 | 21 | 2019 |
| Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents J Bouton, AF d’Almeida, L Maes, G Caljon, S Van Calenbergh, F Hulpia European Journal of Medicinal Chemistry 216, 113290, 2021 | 20 | 2021 |
| Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: discovery of C7-deazapurine analogs as potent antiproliferative nucleosides F Hulpia, S Noppen, D Schols, G Andrei, R Snoeck, S Liekens, ... European Journal of Medicinal Chemistry 157, 248-267, 2018 | 20 | 2018 |
| Phenethyl-4-ANPP: a marginally active byproduct suggesting a switch in illicit fentanyl synthesis routes MM Vandeputte, AJ Krotulski, F Hulpia, S Van Calenbergh, CP Stove Journal of Analytical Toxicology 46 (4), 350-357, 2022 | 17 | 2022 |
| Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function S Neyt, M Vliegen, B Verreet, S De Lombaerde, K Braeckman, C Vanhove, ... Nuclear Medicine and Biology 43 (10), 642-649, 2016 | 16 | 2016 |
| Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis MJ Natto, F Hulpia, ER Kalkman, S Baillie, A Alhejely, Y Miyamoto, ... ACS Infectious Diseases, 2021 | 12 | 2021 |
| Report on a New Opioid NPS: Chemical and In Vitro Functional Characterization of a Structural Isomer of the MT-45 Derivative Diphenpipenol A Cannaert, F Hulpia, M Risseeuw, K Van Uytfanghe, E Deconinck, ... Journal of Analytical Toxicology 45 (2), 134-140, 2021 | 12 | 2021 |
| N6-modification of 7-deazapurine nucleoside analogues as anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and in vivo evaluation C Lin, DGJ Batista, AL Mazzeti, RD Girao, GM de Oliveira, I Karalic, ... European Journal of Medicinal Chemistry 231, 114165, 2022 | 11 | 2022 |
| 4E Interacting Protein as a Potential Novel Drug Target for Nucleoside Analogues in Trypanosoma brucei D Mabille, C Cardoso Santos, R Hendrickx, M Claes, P Takac, C Clayton, ... Microorganisms 9 (4), 826, 2021 | 11 | 2021 |
| 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn) Y Jian, HE Forbes, F Hulpia, MDP Risseeuw, G Caljon, ... Journal of medicinal chemistry 64 (1), 440-457, 2020 | 11 | 2020 |
