| PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia R Ola, A Dubrac, J Han, F Zhang, JS Fang, B Larrivée, M Lee, AA Urarte, ... Nature communications 7 (1), 13650, 2016 | 154 | 2016 |
| Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells JR Kraehling, JH Chidlow, C Rajagopal, MG Sugiyama, JW Fowler, ... Nature communications 7 (1), 13516, 2016 | 152 | 2016 |
| Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys GT Tietjen, SA Hosgood, J DiRito, J Cui, D Deep, E Song, JR Kraehling, ... Science translational medicine 9 (418), eaam6764, 2017 | 129 | 2017 |
| Caveolin-1 regulates atherogenesis by attenuating low-density lipoprotein transcytosis and vascular inflammation independently of endothelial nitric oxide synthase activation CM Ramírez, X Zhang, C Bandyopadhyay, N Rotllan, MG Sugiyama, ... Circulation 140 (3), 225-239, 2019 | 120 | 2019 |
| Contemporary approaches to modulating the nitric oxide–cGMP pathway in cardiovascular disease JR Kraehling, WC Sessa Circulation research 120 (7), 1174-1182, 2017 | 79 | 2017 |
| The impact of the nitric oxide (NO)/soluble guanylyl cyclase (sGC) signaling cascade on kidney health and disease: a preclinical perspective SM Krishnan, JR Kraehling, F Eitner, A Bénardeau, P Sandner International Journal of Molecular Sciences 19 (6), 1712, 2018 | 71 | 2018 |
| Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase M Linnenbaum, M Busker, JR Kraehling, S Behrends PLoS One 7 (4), e35483, 2012 | 58 | 2012 |
| A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity KA Grabińska, BH Edani, EJ Park, JR Kraehling, WC Sessa Journal of Biological Chemistry 292 (42), 17351-17361, 2017 | 46 | 2017 |
| Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency CD Protack, TR Foster, T Hashimoto, K Yamamoto, MY Lee, JR Kraehling, ... Scientific reports 7 (1), 15386, 2017 | 44 | 2017 |
| Endothelial cell autonomous role of Akt1: regulation of vascular tone and ischemia-induced arteriogenesis MY Lee, A Gamez-Mendez, J Zhang, Z Zhuang, DJ Vinyard, J Kraehling, ... Arteriosclerosis, thrombosis, and vascular biology 38 (4), 870-879, 2018 | 38 | 2018 |
| Fluorescent fusion proteins of soluble guanylyl cyclase indicate proximity of the heme nitric oxide domain and catalytic domain T Haase, N Haase, JR Kraehling, S Behrends PLoS One 5 (7), e11617, 2010 | 37 | 2010 |
| Uncoupling caveolae from intracellular signaling in vivo JR Kraehling, Z Hao, MY Lee, DJ Vinyard, H Velazquez, X Liu, RV Stan, ... Circulation research 118 (1), 48-55, 2016 | 28 | 2016 |
| BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells B Tao, JR Kraehling, S Ghaffari, CM Ramirez, S Lee, JW Fowler, WL Lee, ... Journal of Biological Chemistry 295 (52), 18179-18188, 2020 | 25 | 2020 |
| The Amino-Terminus of Nitric Oxide Sensitive Guanylyl Cyclase α1 Does Not Affect Dimerization but Influences Subcellular Localization JR Kraehling, M Busker, T Haase, N Haase, M Koglin, M Linnenbaum, ... PloS one 6 (9), e25772, 2011 | 21 | 2011 |
| Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform … N Haase, T Haase, JR Kraehling, S Behrends Biochemical pharmacology 80 (11), 1676-1683, 2010 | 16 | 2010 |
| Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease A Bénardeau, A Kahnert, T Schomber, J Meyer, M Pavkovic, A Kretschmer, ... Naunyn-Schmiedeberg's archives of pharmacology 394, 2363-2379, 2021 | 15 | 2021 |
| Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney D Stehle, MZ Xu, T Schomber, MG Hahn, F Schweda, S Feil, JR Kraehling, ... British Journal of Pharmacology 179 (11), 2476-2489, 2022 | 13 | 2022 |
| PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun 7: 13650 R Ola, A Dubrac, J Han, F Zhang, JS Fang, B Larrivee, M Lee, AA Urarte, ... | 7 | 2016 |
| Enhanced eNOS activation as the fountain of youth for vascular disease: is BPIFB4 what Ponce de León was looking for? JR Kraehling, WC Sessa Circulation research 117 (4), 309-310, 2015 | 5 | 2015 |
| The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report A Friebe, JR Kraehling, M Russwurm, P Sandner, A Schmidtko Naunyn-schmiedeberg's Archives of Pharmacology 396 (8), 1669-1686, 2023 | 2 | 2023 |
William C SessaYale School of MedicineVerified email at yale.edu
