| Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia S Klossowski, H Miao, K Kempinska, T Wu, T Purohit, EG Kim, ... The Journal of clinical investigation 130 (2), 981-997, 2020 | 162 | 2020 |
| Model studies on the first enzyme-catalyzed Ugi reaction S Kłossowski, B Wiraszka, S Berłożecki, R Ostaszewski Organic Letters 15 (3), 566-569, 2013 | 69 | 2013 |
| Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma A Trzeciecka, S Klossowski, M Bajor, R Zagozdzon, P Gaj, A Muchowicz, ... Oncotarget 7 (2), 1717, 2016 | 55 | 2016 |
| Complexity of blocking bivalent protein–protein interactions: development of a highly potent inhibitor of the menin–mixed-lineage leukemia interaction D Borkin, S Klossowski, J Pollock, H Miao, BM Linhares, K Kempinska, ... Journal of medicinal chemistry 61 (11), 4832-4850, 2018 | 50 | 2018 |
| Studies toward novel peptidomimetic inhibitors of thioredoxin–thioredoxin reductase system S Kłossowski, A Muchowicz, M Firczuk, M Swiech, A Redzej, J Golab, ... Journal of medicinal chemistry 55 (1), 55-67, 2012 | 46 | 2012 |
| Menin regulates the serine biosynthetic pathway in Ewing sarcoma LK Svoboda, SSK Teh, S Sud, S Kerk, A Zebolsky, S Treichel, D Thomas, ... The Journal of pathology 245 (3), 324-336, 2018 | 44 | 2018 |
| Adenanthin targets proteins involved in the regulation of disulphide bonds A Muchowicz, M Firczuk, J Chlebowska, D Nowis, J Stachura, ... Biochemical pharmacology 89 (2), 210-216, 2014 | 43 | 2014 |
| Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma K Kempinska, B Malik, D Borkin, S Klossowski, S Shukla, H Miao, J Wang, ... Molecular cancer therapeutics 17 (1), 26-38, 2018 | 34 | 2018 |
| Substituted inhibitors of menin-MLL and methods of use T Wu, L Li, Y Wang, P Ren, J Grembecka, T Cierpicki, S Klossowski, ... US Patent 10,781,218, 2020 | 28 | 2020 |
| SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress A Muchowicz, M Firczuk, M Wachowska, M Kujawa, E Jankowska-Steifer, ... Biochemical Pharmacology 93 (4), 418-427, 2015 | 26 | 2015 |
| Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity DS Rogawski, J Deng, H Li, H Miao, D Borkin, T Purohit, J Song, J Chase, ... Nature communications 12 (1), 2792, 2021 | 22 | 2021 |
| Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations H Miao, EG Kim, D Chen, T Purohit, K Kempinska, J Ropa, S Klossowski, ... Blood, The Journal of the American Society of Hematology 136 (25), 2958-2963, 2020 | 22 | 2020 |
| Enzymatic Ugi reaction with amines and cyclic imines A Żądło‐Dobrowolska, S Kłossowski, D Koszelewski, D Paprocki, ... Chemistry–A European Journal 22 (46), 16684-16689, 2016 | 22 | 2016 |
| Methods and compositions for inhibiting the interaction of menin with MLL proteins J Grembecka, T Cierpicki, D Borkin, J Pollock, L Li, T Wu, J Feng, P Ren, ... US Patent 10,077,271, 2018 | 18 | 2018 |
| Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity W Szymanski, M Zwolinska, S Klossowski, I Młynarczuk-Biały, Ł Biały, ... Bioorganic & Medicinal Chemistry 22 (5), 1773-1781, 2014 | 18 | 2014 |
| Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C C Carpenter, RJ Sorenson, Y Jin, S Klossowski, T Cierpicki, M Gnegy, ... Bioorganic & medicinal chemistry 24 (21), 5495-5504, 2016 | 17 | 2016 |
| Theoretical models of inhibitory activity for inhibitors of protein–protein interactions: targeting menin–mixed lineage leukemia with small molecules W Jedwabny, S Kłossowski, T Purohit, T Cierpicki, J Grembecka, ... MedChemComm 8 (12), 2216-2227, 2017 | 8 | 2017 |
| Enzymatic synergism in the synthesis of β‐keto esters C Wiśniewska, D Koszelewski, M Zysk, S Kłossowski, A Żądło, A Brodzka, ... European Journal of Organic Chemistry 2015 (24), 5432-5437, 2015 | 8 | 2015 |
| Chemoenzymatic synthesis and application of a new, easily chiral auxiliary for the synthesis of peptidomimetics via an Ugi reaction S Klossowski, A Brodzka, M Zysk, R Ostaszewski Tetrahedron: Asymmetry 25 (5), 435-442, 2014 | 8 | 2014 |
| Bridged bicyclic inhibitors of menin-MLL and methods of use T Wu, L Li, Y Wang, P Ren, J Grembecka, T Cierpicki, S Klossowski, ... US Patent 10,752,639, 2020 | 7 | 2020 |
