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Madeleine Fletcher
Madeleine Fletcher
Verified email at gsk.com
Title
Cited by
Cited by
Year
Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau, PM Sexton, LJ Miller, JM Ahn, ...
Pharmacological reviews 68 (4), 954-1013, 2016
3042016
Activation of the GLP-1 receptor by a non-peptidic agonist
P Zhao, YL Liang, MJ Belousoff, G Deganutti, MM Fletcher, FS Willard, ...
Nature 577 (7790), 432-436, 2020
1312020
Toward a structural understanding of class B GPCR peptide binding and activation
YL Liang, MJ Belousoff, P Zhao, C Koole, MM Fletcher, TT Truong, ...
Molecular cell 77 (3), 656-668. e5, 2020
952020
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity …
YL Liang, MJ Belousoff, MM Fletcher, X Zhang, M Khoshouei, G Deganutti, ...
ACS pharmacology & translational science 3 (2), 263-284, 2020
742020
Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists
MM Fletcher, ML Halls, P Zhao, L Clydesdale, A Christopoulos, ...
Biochemical Pharmacology 156, 406-419, 2018
492018
Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure–activity relationships for amylin receptor agonism
R Kowalczyk, MA Brimble, Y Tomabechi, AJ Fairbanks, M Fletcher, ...
Organic & Biomolecular Chemistry 12 (41), 8142-8151, 2014
442014
A structural basis for amylin receptor phenotype
J Cao, MJ Belousoff, YL Liang, RM Johnson, TM Josephs, MM Fletcher, ...
Science 375 (6587), eabm9609, 2022
342022
The complexity of signalling mediated by the glucagon-like peptide-1 receptor
MM Fletcher, ML Halls, A Christopoulos, PM Sexton, D Wootten
Biochemical Society Transactions 44 (2), 582-588, 2016
342016
AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists
MM Fletcher, P Keov, TT Truong, G Mennen, CA Hick, P Zhao, ...
Journal of Pharmacology and Experimental Therapeutics 377 (3), 417-440, 2021
332021
Molecular insights into peptide agonist engagement with the PTH receptor
BP Cary, EJ Gerrard, MJ Belousoff, MM Fletcher, Y Jiang, IC Russell, ...
Structure 31 (6), 668-676. e5, 2023
62023
Understanding VPAC receptor family peptide binding and selectivity
SJ Piper, G Deganutti, J Lu, P Zhao, YL Liang, Y Lu, MM Fletcher, ...
Nature Communications 13 (1), 7013, 2022
42022
Structural insight into selectivity of amylin and calcitonin receptor agonists
J Cao, MJ Belousoff, E Gerrard, R Danev, MM Fletcher, E Dal Maso, ...
Nature Chemical Biology 20 (2), 162-169, 2024
22024
The spatiotemporal control of signalling and trafficking of the GLP-1R
MM Fletcher
Monash University, 2018
12018
Structure-based insight into development of selective and non-selective amylin and calcitonin receptor agonists
J Cao, M Belousoff, R Danev, M Fletcher, E dal Maso, H Schreuder, ...
2022
The Effect of Glycosylation on the Potency of Pramlintide, An Anti-Diabetic Drug
M Fletcher, R Kowalczyk, A Fairbanks, M Brimble, DL Hay
Pharmacology 2013 (formerly BPS Winter Meeting), 2013
2013
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