| Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family AM Lambeir, P Proost, C Durinx, G Bal, K Senten, K Augustyns, ... Journal of Biological Chemistry 276 (32), 29839-29845, 2001 | 347 | 2001 |
| Truncation of macrophage-derived chemokine by CD26/dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction P Proost, S Struyf, D Schols, G Opdenakker, S Sozzani, P Allavena, ... Journal of Biological Chemistry 274 (7), 3988-3993, 1999 | 204 | 1999 |
| Extended structure–activity relationship and pharmacokinetic investigation of (4-quinolinoyl) glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) K Jansen, L Heirbaut, R Verkerk, JD Cheng, J Joossens, P Cos, L Maes, ... Journal of medicinal chemistry 57 (7), 3053-3074, 2014 | 202 | 2014 |
| In vitro antioxidant profile of phenolic acid derivatives P Cos, P Rajan, I Vedernikova, M Calomme, L Pieters, AJ Vlietinck, ... Free radical research 36 (6), 711-716, 2002 | 197 | 2002 |
| When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157 D Rojas-Rivera, T Delvaeye, R Roelandt, W Nerinckx, K Augustyns, ... Cell Death & Differentiation 24 (6), 1100-1110, 2017 | 184 | 2017 |
| Synthesis and evaluation of caffeic acid amides as antioxidants P Rajan, I Vedernikova, P Cos, DV Berghe, K Augustyns, A Haemers Bioorganic & Medicinal Chemistry Letters 11 (2), 215-217, 2001 | 179 | 2001 |
| Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold K Jansen, L Heirbaut, JD Cheng, J Joossens, O Ryabtsova, P Cos, ... ACS medicinal chemistry letters 4 (5), 491-496, 2013 | 176 | 2013 |
| Regulation of intestinal permeability: the role of proteases H Van Spaendonk, H Ceuleers, L Witters, E Patteet, J Joossens, ... World journal of gastroenterology 23 (12), 2106, 2017 | 166 | 2017 |
| Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases P Van der Veken, K Senten, I Kertèsz, I De Meester, AM Lambeir, ... Journal of medicinal chemistry 48 (6), 1768-1780, 2005 | 150 | 2005 |
| Structure− activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors A Belyaev, X Zhang, K Augustyns, AM Lambeir, I De Meester, ... Journal of medicinal chemistry 42 (6), 1041-1052, 1999 | 147 | 1999 |
| Inhibitors of the purine salvage pathway: a valuable approach for antiprotozoal chemotherapy? M Berg, P Van der Veken, A Goeminne, A Haemers, K Augustyns Current medicinal chemistry 17 (23), 2456-2481, 2010 | 123 | 2010 |
| Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells IMD Bastos, P Grellier, NF Martins, G Cadavid-Restrepo, ... Biochemical Journal 388 (1), 29-38, 2005 | 123 | 2005 |
| Natural substrates of dipeptidyl peptidase IV I De Meester, C Durinx, G Bal, P Proost, S Struyf, F Goossens, ... Cellular peptidases in immune functions and diseases 2, 67-87, 2002 | 121 | 2002 |
| Inhibitors targeting RIPK1/RIPK3: old and new drugs S Martens, S Hofmans, W Declercq, K Augustyns, P Vandenabeele Trends in pharmacological sciences 41 (3), 209-224, 2020 | 117 | 2020 |
| Prolyl oligopeptidase stimulates the aggregation of α-synuclein I Brandt, M Gérard, K Sergeant, B Devreese, V Baekelandt, K Augustyns, ... Peptides 29 (9), 1472-1478, 2008 | 109 | 2008 |
| Novel ferroptosis inhibitors with improved potency and ADME properties S Hofmans, TV Berghe, L Devisscher, B Hassannia, S Lyssens, ... Journal of Medicinal Chemistry 59 (5), 2041-2053, 2016 | 106 | 2016 |
| Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents K Augustyns, K Amssoms, A Yamani, PK Rajan, A Haemers Current pharmaceutical design 7 (12), 1117, 2001 | 104 | 2001 |
| Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability K Augustyns, F Vandendriessche, A Van Aerschot, R Busson, C Urbanke, ... Nucleic acids research 20 (18), 4711-4716, 1992 | 100 | 1992 |
| Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator J Joossens, P Van der Veken, AM Lambeir, K Augustyns, A Haemers Journal of medicinal chemistry 47 (10), 2411-2413, 2004 | 99 | 2004 |
| ClpP protease, a promising antimicrobial target C Moreno-Cinos, K Goossens, IG Salado, P Van Der Veken, H De Winter, ... International journal of molecular sciences 20 (9), 2232, 2019 | 96 | 2019 |
