Follow
Karen Sachs
Karen Sachs
Next Generation Analytics, Answer ALS, Massachusetts Institute of Technology
Verified email at alum.mit.edu
Title
Cited by
Cited by
Year
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
SC Bendall, EF Simonds, P Qiu, ED Amir, PO Krutzik, R Finck, ...
Science 332 (6030), 687-696, 2011
22042011
Causal protein-signaling networks derived from multiparameter single-cell data
K Sachs, O Perez, D Pe'er, DA Lauffenburger, GP Nolan
Science 308 (5721), 523-529, 2005
18502005
Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE
P Qiu, EF Simonds, SC Bendall, KD Gibbs, RV Bruggner, MD Linderman, ...
Nature biotechnology 29 (10), 886-891, 2011
9662011
Normalization of mass cytometry data with bead standards
R Finck, EF Simonds, A Jager, S Krishnaswamy, K Sachs, W Fantl, ...
Cytometry Part A 83 (5), 483-494, 2013
5892013
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
B Bodenmiller, ER Zunder, R Finck, TJ Chen, ES Savig, RV Bruggner, ...
Nature biotechnology 30 (9), 858-867, 2012
5352012
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems 6 (1), 13-24, 2018
3132018
Bayesian network approach to cell signaling pathway modeling
K Sachs, D Gifford, T Jaakkola, P Sorger, DA Lauffenburger
Science's STKE 2002 (148), pe38-pe38, 2002
1602002
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments
KD Gibbs Jr, PM Gilbert, K Sachs, F Zhao, HM Blau, IL Weissman, ...
Blood, The Journal of the American Society of Hematology 117 (16), 4226-4233, 2011
632011
Use of bayesian networks for modeling cell signaling systems
G Nolan, O Perez, K Sachs, D Lauffenburger
US Patent App. 11/338,957, 2007
422007
Distinct signaling programs control human hematopoietic stem cell survival and proliferation
DJHF Knapp, CA Hammond, N Aghaeepour, PH Miller, D Pellacani, ...
Blood, The Journal of the American Society of Hematology 129 (3), 307-318, 2017
412017
A Bayesian active learning experimental design for inferring signaling networks
RO Ness, K Sachs, P Mallick, O Vitek
International Conference on Research in Computational Molecular Biology, 134-156, 2017
312017
Structure learning in causal cyclic networks
S Itani, M Ohannessian, K Sachs, GP Nolan, MA Dahleh
Causality: Objectives and assessment, 165-176, 2010
272010
Learning signaling network structures with sparsely distributed data
K Sachs, S Itani, J Carlisle, GP Nolan, D Pe'er, DA Lauffenburger
Journal of Computational Biology 16 (2), 201-212, 2009
272009
Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid LeukemiaNRASG12V-Mediated …
K Sachs, AL Sarver, KE Noble-Orcutt, RS LaRue, ML Antony, D Chang, ...
Cancer research 80 (3), 458-470, 2020
262020
NRAS G12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia
Z Sachs, RS LaRue, HT Nguyen, K Sachs, KE Noble, NA Mohd Hassan, ...
Blood, The Journal of the American Society of Hematology 124 (22), 3274-3283, 2014
242014
Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
EG Baxi, T Thompson, J Li, JA Kaye, RG Lim, J Wu, D Ramamoorthy, ...
Nature neuroscience 25 (2), 226-237, 2022
222022
GateFinder: projection-based gating strategy optimization for flow and mass cytometry
N Aghaeepour, EF Simonds, DJHF Knapp, RV Bruggner, K Sachs, ...
Bioinformatics 34 (23), 4131-4133, 2018
212018
From correlation to causality: statistical approaches to learning regulatory relationships in large-scale biomolecular investigations
RO Ness, K Sachs, O Vitek
Journal of Proteome Research 15 (3), 683-690, 2016
212016
ParaLearn a massively parallel, scalable system for learning interaction networks on FPGAs
N Bani Asadi, CW Fletcher, G Gibeling, EN Glass, K Sachs, D Burke, ...
Proceedings of the 24th ACM International Conference on Supercomputing, 83-94, 2010
162010
High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment
VD Gonzalez, YW Huang, A Delgado-Gonzalez, SY Chen, K Donoso, ...
Cell reports 36 (9), 109632, 2021
142021
The system can't perform the operation now. Try again later.
Articles 1–20