Segui
Xiangqian Kong
Xiangqian Kong
Center for Chemical Biology and Drug Discovery, GIBH
Email verificata su gibh.ac.cn - Home page
Titolo
Citata da
Citata da
Anno
Computational drug discovery
S Ou-Yang, J Lu, X Kong, Z Liang, C Luo, H Jiang
Acta Pharmacologica Sinica 33 (9), 1131-1140, 2012
3852012
Epigenetic therapy inhibits metastases by disrupting premetastatic niches
Z Lu, J Zou, S Li, MJ Topper, Y Tao, H Zhang, X Jiao, W Xie, X Kong, ...
Nature 579 (7798), 284-290, 2020
2522020
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5
KB Harikumar, JW Yester, MJ Surace, C Oyeniran, MM Price, WC Huang, ...
Nature immunology 15 (3), 231-238, 2014
1332014
Aging-like spontaneous epigenetic silencing facilitates Wnt activation, stemness, and BrafV600E-induced tumorigenesis
Y Tao, B Kang, DA Petkovich, YR Bhandari, J In, G Stein-O'Brien, X Kong, ...
Cancer cell 35 (2), 315-328. e6, 2019
1292019
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2
X Kong, L Chen, L Jiao, X Jiang, F Lian, J Lu, K Zhu, D Du, J Liu, H Ding, ...
Journal of medicinal chemistry 57 (22), 9512-9521, 2014
1122014
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA
F Sun, H Liang, X Kong, S Xie, H Cho, X Deng, Q Ji, H Zhang, S Alvarez, ...
Proceedings of the National Academy of Sciences 109 (23), 9095-9100, 2012
1062012
DNA methylation patterns separate senescence from transformation potential and indicate cancer risk
W Xie, I Kagiampakis, L Pan, YW Zhang, L Murphy, Y Tao, X Kong, ...
Cancer cell 33 (2), 309-321. e5, 2018
1012018
Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and oncogenic properties
X Kong, J Chen, W Xie, SM Brown, Y Cai, K Wu, D Fan, Y Nie, ...
Cancer Cell 35 (4), 633-648. e7, 2019
1002019
Molecular basis of NDM-1, a new antibiotic resistance determinant
Z Liang, L Li, Y Wang, L Chen, X Kong, Y Hong, L Lan, M Zheng, ...
PLoS One 6 (8), e23606, 2011
822011
Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats
B Jiang, D Li, Y Deng, F Teng, J Chen, S Xue, X Kong, C Luo, X Shen, ...
PloS one 8 (3), e59621, 2013
802013
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells
Y Cai, HC Tsai, RWC Yen, YW Zhang, X Kong, W Wang, L Xia, SB Baylin
Genome research 27 (4), 533-544, 2017
792017
Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study
X Kong, S Ouyang, Z Liang, J Lu, L Chen, B Shen, D Li, M Zheng, KK Li, ...
PLoS One 6 (9), e25444, 2011
582011
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated …
CY Kuo, X Li, XQ Kong, C Luo, CC Chang, Y Chung, HM Shih, KK Li, ...
Journal of Biological Chemistry 289 (30), 20757-20772, 2014
552014
Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease
F Ye, J Zhang, H Liu, R Hilgenfeld, R Zhang, X Kong, L Li, J Lu, X Zhang, ...
Journal of Biological Chemistry 288 (24), 17643-17653, 2013
552013
Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase
Z Liang, D Zhang, J Ai, L Chen, H Wang, X Kong, M Zheng, H Liu, C Luo, ...
Bioorganic & medicinal chemistry letters 21 (12), 3749-3754, 2011
442011
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction
X Zhang, S Ouyang, X Kong, Z Liang, J Lu, K Zhu, D Zhao, M Zheng, ...
The Journal of Physical Chemistry B 118 (8), 2009-2019, 2014
432014
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase
J Jiang, J Lu, D Lu, Z Liang, L Li, S Ouyang, X Kong, H Jiang, B Shen, ...
PLoS One 7 (5), e36660, 2012
432012
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1
K Zhu, J Lu, Z Liang, X Kong, F Ye, L Jin, H Geng, Y Chen, M Zheng, ...
Journal of computer-aided molecular design 27, 247-256, 2013
422013
c-MET kinase inhibitors: a patent review (2011–2013)
K Zhu, X Kong, D Zhao, Z Liang, C Luo
Expert opinion on therapeutic patents 24 (2), 217-230, 2014
332014
Structure-guided development of small-molecule PRC2 inhibitors targeting EZH2–EED interaction
D Du, D Xu, L Zhu, G Stazi, C Zwergel, Y Liu, Z Luo, Y Li, Y Zhang, K Zhu, ...
Journal of Medicinal Chemistry 64 (12), 8194-8207, 2021
282021
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