|The anticoagulant activation of antithrombin by heparin|
L Jin, JP Abrahams, R Skinner, M Petitou, RN Pike, RW Carrell
Proceedings of the National Academy of Sciences 94 (26), 14683-14688, 1997
|Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function|
JA Irving, RN Pike, AM Lesk, JC Whisstock
Genome research 10 (12), 1845-1864, 2000
|An overview of the serpin superfamily|
RHP Law, Q Zhang, S McGowan, AM Buckle, GA Silverman, W Wong, ...
Genome biology 7 (5), 216, 2006
|Lysine-and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.|
R Pike, W McGraw, J Potempa, J Travis
Journal of Biological Chemistry 269 (1), 406-411, 1994
|A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis|
SW Scally, J Petersen, SC Law, NL Dudek, HJ Nel, KL Loh, ...
The Journal of experimental medicine 210 (12), 2569-2582, 2013
|The multiple forms of trypsin-like activity present in various strains of Porphyromonas gingivalis are due to the presence of either Arg-gingipain or Lys-gingipain.|
J Potempa, R Pike, J Travis
Infection and immunity 63 (4), 1176-1182, 1995
|A common fold mediates vertebrate defense and bacterial attack|
CJ Rosado, AM Buckle, RHP Law, RE Butcher, WT Kan, CH Bird, K Ung, ...
Science 317 (5844), 1548-1551, 2007
|Corruption of innate immunity by bacterial proteases|
J Potempa, RN Pike
Journal of innate immunity 1 (2), 70-87, 2009
|Arginine-Specific Protease fromPorphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion|
A Lourbakos, J Potempa, J Travis, MR D'Andrea, P Andrade-Gordon, ...
Infection and immunity 69 (8), 5121-5130, 2001
|Activation of protease-activated receptors by gingipains fromPorphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity|
A Lourbakos, YP Yuan, AL Jenkins, J Travis, P Andrade-Gordon, ...
Blood, The Journal of the American Society of Hematology 97 (12), 3790-3797, 2001
|Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis Biosynthesis as a proteinase-adhesin polyprotein|
N Pavloff, J Potempa, RN Pike, V Prochazka, MC Kiefer, J Travis, PJ Barr
Journal of Biological Chemistry 270 (3), 1007-1010, 1995
|Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis|
J Travis, R Pike, T Imamura, J Potempa
Journal of periodontal research 32 (1), 120-125, 1997
|Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the …|
T Imamura, RN Pike, J Potempa, J Travis
The Journal of clinical investigation 94 (1), 361-367, 1994
|Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (gingipains) using peptidyl chloromethanes|
J Potempa, R Pike, J Travis
Biological chemistry 378 (3-4), 223-230, 1997
|GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop|
G Fenalti, RHP Law, AM Buckle, C Langendorf, K Tuck, CJ Rosado, ...
Nature structural & molecular biology 14 (4), 280-286, 2007
|Cleavage and activation of proteinase‐activated receptor‐2 on human neutrophils by gingipain‐R from Porphyromonas gingivalis|
A Lourbakos, C Chinni, P Thompson, J Potempa, J Travis, EJ Mackie, ...
FEBS letters 435 (1), 45-48, 1998
|PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites|
J Song, H Tan, AJ Perry, T Akutsu, GI Webb, JC Whisstock, RN Pike
PloS one 7 (11), 2012
|Antithrombin: in control of coagulation|
NS Quinsey, AL Greedy, SP Bottomley, JC Whisstock, RN Pike
The international journal of biochemistry & cell biology 36 (3), 386-389, 2004
|Characterization of the binding activities of proteinase-adhesin complexes from Porphyromonas gingivalis.|
RN Pike, J Potempa, W McGraw, TH Coetzer, J Travis
Journal of Bacteriology 178 (10), 2876-2882, 1996
|Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.|
TM Osicka, Y Yu, S Panagiotopoulos, SP Clavant, Z Kiriazis, RN Pike, ...
Diabetes 49 (1), 87-93, 2000