Nicholas C. Wu
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A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv, CKP Mok, IA Wilson
Science 368 (6491), 630-633, 2020
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He, O Limbo, C Smith, ...
Science 369 (6506), 956-963, 2020
Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections
H Lv, NC Wu, OTY Tsang, M Yuan, RAPM Perera, WS Leung, RTY So, ...
Cell reports 31 (9), 107725, 2020
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
AG York, KJ Williams, JP Argus, QD Zhou, G Brar, L Vergnes, EE Gray, ...
Cell 163 (7), 1716-1729, 2015
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020
RAPM Perera, CKP Mok, OTY Tsang, H Lv, RLW Ko, NC Wu, M Yuan, ...
Eurosurveillance 25 (16), 2000421, 2020
Structural basis of a shared antibody response to SARS-CoV-2
M Yuan, H Liu, NC Wu, CCD Lee, X Zhu, F Zhao, D Huang, W Yu, Y Hua, ...
Science, 2020
A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain
CA Olson, NC Wu, R Sun
Current Biology 24 (22), 2643-2651, 2014
A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
NC Wu, SJ Zost, AJ Thompson, D Oyen, CM Nycholat, R McBride, ...
PLoS pathogens 13 (10), e1006682, 2017
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
JH Lee, R Andrabi, CY Su, A Yasmeen, JP Julien, L Kong, NC Wu, ...
Immunity 46 (4), 690-702, 2017
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
J Kreye, SM Reincke, HC Kornau, E Sánchez-Sendin, VM Corman, H Liu, ...
Cell 183 (4), 1058-1069. e19, 2020
Adaptation in protein fitness landscapes is facilitated by indirect paths
NC Wu, L Dai, CA Olson, JO Lloyd-Smith, R Sun
eLife 5, e16965, 2016
A perspective on the structural and functional constraints for immune evasion: Insights from influenza virus
NC Wu, IA Wilson
Journal of Molecular Biology 429 (17), 2694-2709, 2017
High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution
NC Wu, AP Young, LQ Al-Mawsawi, CA Olson, J Feng, H Qi, SH Chen, ...
Scientific reports 4, 4942, 2014
Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
JM Lee, J Huddleston, MB Doud, KA Hooper, NC Wu, T Bedford, ...
Proceedings of the National Academy of Sciences 115 (35), E8276-E8285, 2018
Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa
S Le, X Yao, S Lu, Y Tan, X Rao, M Li, X Jin, J Wang, Y Zhao, NC Wu, ...
Scientific reports 4, 4738, 2014
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
H Liu, NC Wu, M Yuan, S Bangaru, JL Torres, TG Caniels, ...
Immunity 53 (6), 1272-1280. e5, 2020
An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain
NC Wu, M Yuan, H Liu, CCD Lee, X Zhu, S Bangaru, JL Torres, ...
Cell reports 33 (3), 108274, 2020
A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity
H Qi, CA Olson, NC Wu, R Ke, C Loverdo, V Chu, S Truong, R Remenyi, ...
PLoS pathogens 10 (4), e1004064, 2014
Structural insights into the design of novel anti-influenza therapies
NC Wu, IA Wilson
Nature structural & molecular biology 25 (2), 115-121, 2018
Systematic identification of H274Y compensatory mutations in influenza A virus neuraminidase by high-throughput screening
NC Wu, AP Young, S Dandekar, H Wijersuriya, LQ Al-Mawsawi, TT Wu, ...
Journal of virology 87 (2), 1193-1199, 2013
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