Zhongjie Liang
Zhongjie Liang
Associate Professor, Center of Systems Biology, Soochow University
Email verificata su suda.edu.cn
Titolo
Citata da
Citata da
Anno
Computational drug discovery
S Ou-Yang, J Lu, X Kong, Z Liang, C Luo, H Jiang
Acta Pharmacologica Sinica 33 (9), 1131-1140, 2012
1652012
Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance
F Sun, Y Ding, Q Ji, Z Liang, X Deng, CCL Wong, C Yi, L Zhang, S Xie, ...
Proceedings of the National Academy of Sciences 109 (38), 15461-15466, 2012
1292012
Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling
S Wang, X Huang, D Sun, X Xin, Q Pan, S Peng, Z Liang, C Luo, Y Yang, ...
PloS one 7 (5), e37427, 2012
782012
Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation
J Wang, L Chen, SH Sinha, Z Liang, H Chai, S Muniyan, YW Chou, ...
Journal of medicinal chemistry 55 (18), 7978-7987, 2012
642012
Molecular basis of NDM-1, a new antibiotic resistance determinant
Z Liang, L Li, Y Wang, L Chen, X Kong, Y Hong, L Lan, M Zheng, ...
PLoS One 6 (8), e23606, 2011
582011
Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study
X Kong, S Ouyang, Z Liang, J Lu, L Chen, B Shen, D Li, M Zheng, KK Li, ...
PLoS One 6 (9), e25444, 2011
462011
Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-Amyloid peptide aggregation inhibitors
Y Zhou, C Jiang, Y Zhang, Z Liang, W Liu, L Wang, C Luo, T Zhong, Y Sun, ...
Journal of medicinal chemistry 53 (15), 5449-5466, 2010
432010
DNA methyltransferase inhibitors: an updated patent review (2012-2015)
P Xu, G Hu, C Luo, Z Liang
Expert opinion on therapeutic patents 26 (9), 1017-1030, 2016
392016
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies
Z Liang, L Zhang, L Li, J Liu, H Li, L Zhang, L Chen, K Cheng, M Zheng, ...
European journal of medicinal chemistry 46 (6), 2011
392011
Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets
J Lu, H Zeng, Z Liang, L Chen, L Zhang, H Zhang, H Liu, H Jiang, B Shen, ...
Scientific reports 5, 14739, 2015
332015
Identification and synthesis of N′-(2-oxoindolin-3-ylidene) hydrazide derivatives against c-Met kinase
Z Liang, D Zhang, J Ai, L Chen, H Wang, X Kong, M Zheng, H Liu, C Luo, ...
Bioorganic & medicinal chemistry letters 21 (12), 3749-3754, 2011
312011
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1
K Zhu, J Lu, Z Liang, X Kong, F Ye, L Jin, H Geng, Y Chen, M Zheng, ...
Journal of computer-aided molecular design 27 (3), 247-256, 2013
302013
c-MET kinase inhibitors: a patent review (2011–2013)
K Zhu, X Kong, D Zhao, Z Liang, C Luo
Expert Opinion on Therapeutic Patents 24 (2), 217-230, 2014
292014
Investigation of the acetylation mechanism by GCN5 histone acetyltransferase
J Jiang, J Lu, D Lu, Z Liang, L Li, S Ouyang, X Kong, H Jiang, B Shen, ...
PLoS One 7 (5), e36660, 2012
292012
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors
D Zhang, J Ai, Z Liang, C Li, X Peng, YC Ji, H Jiang, M Geng, C Luo, H Liu
Bioorganic & medicinal chemistry 20 (17), 5169-5180, 2012
272012
Catalytic mechanism of histone acetyltransferase p300: from the proton transfer to acetylation reaction
X Zhang, S Ouyang, X Kong, Z Liang, J Lu, K Zhu, D Zhao, M Zheng, ...
The Journal of Physical Chemistry B 118 (8), 2009-2019, 2014
242014
Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2?
Z Liang, T Shi, S Ouyang, H Li, K Yu, W Zhu, C Luo, H Jiang
The journal of physical chemistry B 114 (36), 11927-11933, 2010
232010
Development of a novel class of B-Raf v600e-selective inhibitors through virtual screening and hierarchical hit optimization
X Kong, J Qin, Z Li, A Vultur, L Tong, E Feng, G Rajan, S Liu, J Lu, Z Liang, ...
Organic & biomolecular chemistry 10 (36), 7402-7417, 2012
212012
Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1)
Y Xie, R Zhou, F Lian, Y Liu, L Chen, Z Shi, N Zhang, M Zheng, B Shen, ...
Organic & biomolecular chemistry 12 (47), 9665-9673, 2014
192014
Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1
R Zhang, X Li, Z Liang, K Zhu, J Lu, X Kong, S Ouyang, L Li, YG Zheng, ...
PLoS One 8 (8), e72424, 2013
192013
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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